Genipin-treated chitosan nanofibers as a novel scaffold for nerve guidance channel design

Lau, Yu-Ting; Kwok, Lam-Fung; Tam, Kin-Wai; Chan, Ying-Shing; Shum, Dky; Shea, Graham Ka‐Hon

doi:10.1016/j.colsurfb.2017.11.061

Cited by 38 publications

(15 citation statements)

References 30 publications

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“…They found an increased stiffness, resistance to swelling, and lysozymal degradation of nanofibers, resulting in a better alignment and proliferation of the Schwann cell culture. Finally, in a model of peripheral nerve regeneration, neurite growth rate upon genipin-treated nanofibers demonstrated a 100% increase [133].…”

Section: Nanofibersmentioning

confidence: 93%

Biomaterials in Neurodegenerative Disorders: A Promising Therapeutic Approach

Bordoni

Scarian

Rey

et al. 2020

IJMS

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Neurodegenerative disorders (i.e., Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and spinal cord injury) represent a great problem worldwide and are becoming prevalent because of the increasing average age of the population. Despite many studies having focused on their etiopathology, the exact cause of these diseases is still unknown and until now, there are only symptomatic treatments. Biomaterials have become important not only for the study of disease pathogenesis, but also for their application in regenerative medicine. The great advantages provided by biomaterials are their ability to mimic the environment of the extracellular matrix and to allow the growth of different types of cells. Biomaterials can be used as supporting material for cell proliferation to be transplanted and as vectors to deliver many active molecules for the treatments of neurodegenerative disorders. In this review, we aim to report the potentiality of biomaterials (i.e., hydrogels, nanoparticles, self-assembling peptides, nanofibers and carbon-based nanomaterials) by analyzing their use in the regeneration of neural and glial cells their role in axon outgrowth. Although further studies are needed for their use in humans, the promising results obtained by several groups leads us to suppose that biomaterials represent a potential therapeutic approach for the treatments of neurodegenerative disorders.

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Section: Nanofibersmentioning

confidence: 93%

Biomaterials in Neurodegenerative Disorders: A Promising Therapeutic Approach

Bordoni

Scarian

Rey

et al. 2020

IJMS

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“…Indeed, an amine group in the chitosan endures nucleophilic attack at the COH group of genipin, leading to covalent bond formation between the aldehyde group and the secondary amine and a double bond formation at the carbon in the ortho ‐position . Previous studies showed resistance to lysosomal degradation and swelling, and a 100% increase of neurite growth rate on the surface of genipin‐treated nanofibers . There are several covalent modes to provide chemically reactive surfaces for immobilization of biomolecules to the scaffolds .…”

Section: Surface Modification Methodsmentioning

confidence: 99%

Controlling Cell Behavior through the Design of Biomaterial Surfaces: A Focus on Surface Modification Techniques

Amani

Arzaghi

Bayandori

et al. 2019

Adv Materials Inter

290

200

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Surface interaction at the biomaterial–cell interface is essential for a variety of cellular functions, such as adhesion, proliferation, and differentiation. Nevertheless, changes in the biointerface enable to trigger specific cell signaling and result in different cellular responses. In order to manufacture biomaterials with higher functionality, biomaterials containing immobilized bioactive ligands have been widely introduced and employed for tissue engineering and regenerative medicine applications. Moreover, a number of physical and chemical strategies have been used to improve the functionality of biomaterials and specifically at the material interface. Here, the interactions between materials and cells at the interface levels are described. Then, the importance of surface properties in cell function is discussed and recent methods for surface modifications are systematically highlighted. Additionally, the impact of bulk material properties on the cellular responses is briefly reviewed.

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“…It can interact with free amino groups of proteins to form dark blue pigments used in the fabrication of food dyes. It has good anti-inflammatory and anti-allergic effects, making it more suitable for use as medical materials [23,24]. Most importantly, genipin is about 10,000 times less toxic than glutaraldehyde and has been used in food processing [25,26].…”

Section: Introductionmentioning

confidence: 99%

Food-Grade Gelatin Nanoparticles: Preparation, Characterization, and Preliminary Application for Stabilizing Pickering Emulsions

Feng

Dai

et al. 2019

Foods

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In this paper, the food-grade gelatin nanoparticles (GNPs) were prepared by a two-step desolvation method and using genipin as a cross-linker. The GNPs with narrow size distribution and good dispersion could be obtained only at pH 12. The effect of the genipin dosage (8–12 wt%) on the GNPs was systematically investigated. The results showed that the cross-linking degree of the GNPs increased with the increasing dosage of genipin, thus leading to a more obvious cross-linking morphology observed from scanning electron microscope (SEM). The obtained GNPs showed a good dispersibility with a size range of 386–438 nm. However, the GNPs cross-linked by 8 wt% genipin dosage revealed a relatively higher size because of the aggregation induced by hydrogen bond. The 10 wt% group had good thermal stability and storage stability. The optical microscopy results showed that the Pickering emulsions (30–50 vol% internal phase) stabilized by the GNPs had good uniformity and stability, even after 30 days of storage time, suggesting that the stable GNPs had great potential in food-grade Pickering emulsions.

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Genipin-treated chitosan nanofibers as a novel scaffold for nerve guidance channel design

Cited by 38 publications

References 30 publications

Biomaterials in Neurodegenerative Disorders: A Promising Therapeutic Approach

Biomaterials in Neurodegenerative Disorders: A Promising Therapeutic Approach

Controlling Cell Behavior through the Design of Biomaterial Surfaces: A Focus on Surface Modification Techniques

Food-Grade Gelatin Nanoparticles: Preparation, Characterization, and Preliminary Application for Stabilizing Pickering Emulsions

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