Genipap (Genipa americana L.) juice intake biomarkers after medium-term consumption

Dickson, Livia; Tenon, Mathieu; Svilar, Ljubica; Fança-Berthon, Pascale; Martin, Jean‐Charles; Rogez, Hervé; Vaillant, Fabrice

doi:10.1016/j.foodres.2020.109375

Cited by 7 publications

(2 citation statements)

References 52 publications

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“…Genipap (Genipa americana L.) is a known fruit with medicinal value. Biomarkers after the administration of genipap in human urine is identified by LC-MS (Dickson et al, 2020).…”

Section: Fruit Quality Formationmentioning

confidence: 99%

Research Progress and Trends in Metabolomics of Fruit Trees

Yan

Duan

et al. 2022

Front. Plant Sci.

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Metabolomics is an indispensable part of modern systems biotechnology, applied in the diseases’ diagnosis, pharmacological mechanism, and quality monitoring of crops, vegetables, fruits, etc. Metabolomics of fruit trees has developed rapidly in recent years, and many important research results have been achieved in combination with transcriptomics, genomics, proteomics, quantitative trait locus (QTL), and genome-wide association study (GWAS). These research results mainly focus on the mechanism of fruit quality formation, metabolite markers of special quality or physiological period, the mechanism of fruit tree’s response to biotic/abiotic stress and environment, and the genetics mechanism of fruit trait. According to different experimental purposes, different metabolomic strategies could be selected, such as targeted metabolomics, non-targeted metabolomics, pseudo-targeted metabolomics, and widely targeted metabolomics. This article presents metabolomics strategies, key techniques in metabolomics, main applications in fruit trees, and prospects for the future. With the improvement of instruments, analysis platforms, and metabolite databases and decrease in the cost of the experiment, metabolomics will prompt the fruit tree research to achieve more breakthrough results.

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“…Genipap (Genipa americana L.) is a known fruit with medicinal value. Biomarkers after the administration of genipap in human urine is identified by LC-MS (Dickson et al, 2020).…”

Section: Fruit Quality Formationmentioning

confidence: 99%

Research Progress and Trends in Metabolomics of Fruit Trees

Yan

Duan

et al. 2022

Front. Plant Sci.

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“…Genipa americana is an exotic fruit largely consumed and well known, in Amazonian pharmacopeia, to treat anemia, measles and uterine cancer. It is also used as a diuretic, digestive, healing, laxative and antiseptic [ 178 ]. Two fractions, with different molecular weights, of glycoconjugates extracted from Genipa americana leaves (PE-Ga) composed mainly by arabinose, galactose and uronic acid, are able to prolong APTT and to inhibit by 48% the ADP-induced platelet aggregation at a concentration of 100 μg/μL [ 179 ].…”

Section: Antiplatelet and Anticoagulant Activity Of Plants And Their Bioactive Compoundsmentioning

confidence: 99%

Bioactive Natural Compounds with Antiplatelet and Anticoagulant Activity and Their Potential Role in the Treatment of Thrombotic Disorders

Lamponi

2021

Life

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Natural anticoagulant drugs can be obtained from plants, rich in secondary bioactive metabolites which, in addition to being effective antioxidants, also possess anticoagulant and antiplatelet properties and, for this reason, can be excellent candidates for the treatment of thrombotic diseases. This review reports an overview of the hemostatic process and thrombotic disorders together with data on plants, more and less common from around the world, containing bioactive compounds characterized by antiplatelet and anticoagulant activity. The reported literature was obtained from Medline, PubMed, Elsevier, Web of Science, Google Scholar considering only articles in the English language, published in peer-reviewed journals. The number of citations of the articles and the impact factor of the journals were other parameters used to select the scientific papers to be included in the review. The analysis of the literature data selected demonstrates that many plants’ bioactive compounds show antiplatelet and anticoagulant activity that make them potential candidates to be used as new natural compounds able to interfere with both primary and secondary hemostasis. Moreover, they could be used together with anticoagulants currently administered in clinical practice to increase their efficacy and to reduce complications in the treatment of thrombotic disorders.

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