Geng et al. reply

Wang, Xinyi; Sun, Guangqiang; Feng, Teng; Zhang, Jing; Huang, Xun; Wang, Tao; Xie, Zuoquan; Chu, Xingkun; Yang, Jun; Wang, Huan; Chang, Shuaishuai; Gong, Yanxue; Ruan, Lingfei; Zhang, Guanqun; Yan, Siyuan; Wen, Li-Li; Du, Chen; Yang, Da; Zhang, Qingli; Liu, Jia; Zhang, Haiyan; Ge, Changrong; Xiao, Shifu; Ding, Jian; Geng, Meiyu

doi:10.1038/s41422-020-0377-7

Cited by 17 publications

(16 citation statements)

References 12 publications

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“…1c ), indicating the enhancing effect of RNA length on LLPS. The percentage of area occupied by the dense phase relative to the solute phase 6 increased rapidly from ~10% for 10-nt RNA (U10) to ~70% for 20-nt RNA (U20) and reached ~80% for 40-nt and 60-nt RNAs (U40 and U60) (Fig. 1d ).…”

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Liquid–liquid phase separation by SARS-CoV-2 nucleocapsid protein and RNA

et al. 2020

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Dear Editor, The COVID-19 pandemic worldwide is caused by a novel coronavirus SARS-CoV-2 (the severe acute respiratory syndrome coronavirus 2). 1 After viral invasion into the host cells, the~30 kb viral genome RNA injected is translated into structural and nonstructural proteins to replicate viral genome and assemble more viral particles. Many copies of nucleocapsid (N) protein can bind to viral genome RNA and pack it into~100 nm particles, assisting membrane (M) and envelope (E) proteins to efficiently assemble the viral envelope. 2 The exact molecular mechanism by which N protein packs up the viral genome still remains elusive. An N protein of SARS-CoV-2 consists of an N-terminal RNAbinding domain (NTD) and a C-terminal dimerization domain (CTD) and shares~90% sequence identity with N protein of SARS-CoV (Supplementary information, Fig. S1a). The regions located between the N-terminus and NTD, between NTD and CTD, and between CTD and the C-terminus of the N protein of SARS-CoV-2 (thereafter referred to as N protein) are predicted to be intrinsically disordered (Supplementary information, Fig. S1b, c). At neutral pH, the N protein is positively charged (+24 e), consistent with its strong binding affinity with negatively charged

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“…Nevertheless, A recent study suggests that Chloroquine is a zinc ionophore. 11 Chloroquine has been shown to effectively inhibit the infection of SARS-CoV-2, 12 but the mechanism is still not known. We speculate that Chloroquine may inhibit N protein/RNA LLPS through chelating the free Zn 2+ in cytosol.…”

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confidence: 99%

Liquid–liquid phase separation by SARS-CoV-2 nucleocapsid protein and RNA

et al. 2020

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“…Unfortunately, no drug or vaccine is currently approved to combat the outbreak of SARS-CoV-2 [ 13 ]. However, there are currently an accelerated efforts to repurpose some FDA approved drugs against COVID-19 like Chloroquine and Remdesivir [ 14 ]. Multiple programs are currently ongoing to develop SARS-CoV-2 vaccine by using whole virus, viral spike protein or mRNA [ 15 ].…”

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confidence: 99%

Towards the design of epitope candidates for Coronavirus 2

Odhar¹

2020

Bioinformation

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The authors state that they adhere with COPE guidelines on publishing ethics as described elsewhere at https://publicationethics.org/. The authors also undertake that they are not associated with any other third party (governmental or non-governmental agencies) linking with any form of unethical issues connecting to this publication. The authors also declare that they are not withholding any information that is misleading to the publisher in regard to this article.

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“…A recent paper in Cell Research by Wang et al offers a nice inroad into the genetics and evolution of dominance behavior. 5 This study took a somewhat unusual approach. The authors began by performing a whole-genome sequence comparison across 16 amniotes (12 placental mammals, one marsupial, two birds and one reptile) to screen for genomic regions exhibiting accelerated evolution in the common ancestral lineage leading to placentals.…”

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confidence: 99%

Social dominance hierarchy: toward a genetic and evolutionary understanding

Lahn

2020

Cell Res

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Geng et al. reply

Cited by 17 publications

References 12 publications

Liquid–liquid phase separation by SARS-CoV-2 nucleocapsid protein and RNA

Liquid–liquid phase separation by SARS-CoV-2 nucleocapsid protein and RNA

Towards the design of epitope candidates for Coronavirus 2

Social dominance hierarchy: toward a genetic and evolutionary understanding

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