GeneXpert MTB/RIF on bronchoalveolar lavage samples in children with suspected complicated intrathoracic tuberculosis: A pilot study

Walters, Elisabetta; Goussard, Pierre; Bosch, Corné; Hesseling, Anneke C.; Gie, Robert P.

doi:10.1002/ppul.22970

Cited by 43 publications

(36 citation statements)

References 13 publications

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“…Sin embargo, la muestra es pequeña y no hay datos concluyentes para decir que esta muestra sea mejor que las otras 30 . En nuestro estudio, el LBA aportó un resultado positivo en la prueba molecular, no confirmado por cultivo.…”

Section: Discussionunclassified

Xpert MTB/RIF® como herramienta diagnóstica en una cohorte de niños menores de 15 años con sospecha clínica de tuberculosis pulmonar en un hospital de alta complejidad de Medellín

Muñoz

Moreno

et al. 2016

Infectio

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Section: Discussionunclassified

Xpert MTB/RIF® como herramienta diagnóstica en una cohorte de niños menores de 15 años con sospecha clínica de tuberculosis pulmonar en un hospital de alta complejidad de Medellín

Muñoz

Moreno

et al. 2016

Infectio

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“…Nineteen studies are available on the use of Xpert MTB/RIF in the pediatric population [64,[69][70][71][72][73][74][75][76][77][78][79][80][81][82][83][84][85][86]. Overall, the sensitivity of this test in respiratory samples compared to culture for TB detection ranged between 39 and 100%, and in particular for sputum varied from 57 to 100%, for gastric lavage/aspiration from 64 to 80% and for nasopharyngeal aspirate from 39 to 65%.…”

Section: Xpert Mtb/rifmentioning

confidence: 91%

What steps do we need to take to improve diagnosis of tuberculosis in children?

Venturini

Remaschi

Berti

et al. 2015

Expert Review of Anti-infective Therapy

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Tuberculosis still represents a big global public health challenge. The diagnosis of tuberculosis and the differentiation between active and latent tuberculosis remain difficult, particularly in childhood, because of the lack of a gold standard test for diagnosis. In the last decade, novel diagnostic assays have been developed. Among immunologic tests, new assays based on the measurement of different cytokines released by specific T cells in response to Mycobacterium tuberculosis antigens, other than INF-γ, have been investigated. Promising results rely on nucleic acid amplification techniques, also able to detect drugs resistance. Innovative research fields studied the modifications of CD27 expression in T cells as well as different host gene expression in response to M. tuberculosis. Further studies are needed to assess the diagnostic value and the accuracy of these new assays.

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“…BAL Gene Xpert MTB-Rif increased the diagnostic yield on BAL samples by 14% 20 . In the 7 children where the isolation of Mycobacterium tuberculosis failed the bronchoscopic image of the TB lymph node ulcerating into the airway was highly suggestive of TB adding an additional reason why bronchoscopy was useful in children with suspected TB.…”

Section: Discussionmentioning

confidence: 99%

The indications and role of paediatric bronchoscopy in a developing country, with high prevalence of pulmonary tuberculosis and HIV

Webster

Goussard

Gie

et al. 2017

Expert Review of Respiratory Medicine

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Bronchoscopy is an important investigation in the diagnosis and management of childhood respiratory diseases widely used in high income countries. There is limited information on value of paediatric bronchoscopy in low and middle income countries (LMIC). Aims and Objectives:Aim of this study was to describe the indications, findings and complications of paediatric bronchoscopy in a middle income country with a high prevalence of tuberculosis (TB) and HIV. Methodology:A retrospective analysis of a database which included all bronchoscopies on neonates and children over a 3.5 year period (January 2010 to June 2013) in a tertiary care children's hospital in South Africa. Results and Discussion:A total of 509 bronchoscopies, of which 502 (98%) were fibre-optic bronchoscopies, were performed on neonates (2.3%) and children (median age = 18 months; range 1 day-14.6 years)( (male=58%) of which 5.1% were HIV-infected. The main indications were: large airway compression 40% (n = 204) complicated pneumonia (25 %) and persistent stridor (15 %). Pathology was observed in 64% (n = 319) of bronchoscopes . The most common pathology seen was lymph node compression of the airways (21%), and upper airway pathology (12%). Interventional procedures were performed in 112 cases (22%), the commonest being removing foreign bodies removal (30%), endobronchial lymph node enucleation (30%) and transbronchial needle aspiration (20%). No major complications occurred during or following bronchoscopy. ConclusionThe diagnostic yield of paediatric bronchoscopy did not significantly differ from those reported from high income countries emphasising the importance of paediatric bronchoscopy in the management of childhood lung disease in LMICs.

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GeneXpert MTB/RIF on bronchoalveolar lavage samples in children with suspected complicated intrathoracic tuberculosis: A pilot study

Abstract: BAL Xpert resulted in additional diagnostic yield and also in the rapid detection of drug resistance in children with complicated intrathoracic TB. The clinical impact of this modality should be further evaluated in children.

Cited by 43 publications

References 13 publications

Xpert MTB/RIF® como herramienta diagnóstica en una cohorte de niños menores de 15 años con sospecha clínica de tuberculosis pulmonar en un hospital de alta complejidad de Medellín

Xpert MTB/RIF® como herramienta diagnóstica en una cohorte de niños menores de 15 años con sospecha clínica de tuberculosis pulmonar en un hospital de alta complejidad de Medellín

What steps do we need to take to improve diagnosis of tuberculosis in children?

The indications and role of paediatric bronchoscopy in a developing country, with high prevalence of pulmonary tuberculosis and HIV

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