Genetics, prefrontal cortex, and cognitive control: a twin study of event-related brain potentials in a response inhibition task

Anokhin, Andrey P.; Heath, Andrew C.; Myers, Erin M.

doi:10.1016/j.neulet.2004.07.036

Cited by 53 publications

(51 citation statements)

References 22 publications

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“…However, the twin studies that have investigated P3 heritability investigated children or adolescent samples (Carlson et al, 2002;Katsanis et al, 1997;O'Connor et al, 1994;van Baal et al, 1998;van Beijsterveldt et al, 2001). To our knowledge, only one adult twin study with sufficient power to discriminate genetic from common environmental factors has looked at the P3 (Anokhin et al, 2004). Using a go/no-go task rather than an oddball task, P3 heritability was comparable (41% and 58% for go and no-go P3 respectively) to that in adolescent twins.…”

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confidence: 96%

Genetic Contribution to the P3 in Young and Middle-Aged Adults

et al. 2007

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Previous studies in young and adolescent twins suggested substantial genetic contributions to the amplitude and latency of the P3 evoked by targets in an oddball paradigm. Here we examined whether these findings can be generalized to adult samples. A total of 651 twins and siblings from 292 families participated in a visual oddball task. In half of the subjects the age centered around 26 (young adult cohort), in the other half the age centered around 49 (middle-aged adult cohort). P3 peak amplitude and latency were scored for 3 midline leads Pz, Cz, and Fz. No cohort differences in heritability were found. P3 amplitude (∼50%) and latency (∼45%) were moderately heritable for the 3 leads. A single genetic factor influenced latency at all electrodes, suggesting a single P3 timing mechanism. Specific genetic factors influenced amplitude at each lead, suggesting local modulation of the P3 once triggered. Genetic analysis of the full event-related potential waveform showed that P3 heritability barely changes from about 100 ms before to 100 ms after the peak. Age differences are restricted to differences in means and variances, but the proportion of genetic variance as part of the total variance of midline P3 amplitude and latency does not change from young to middle-aged adulthood.

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confidence: 96%

Genetic Contribution to the P3 in Young and Middle-Aged Adults

et al. 2007

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“…For upper alpha synchronization, heritability varied from 35% to 65%, and for theta desynchronization, heritability ranged from 31% to 50%. These estimates are lower than heritability of resting state oscillatory power in the same bands (Smit et al, 2005) but similar to other evoked responses such as the P300 and N1 (Anokhin, Heath, & Myers, 2004;Smit et al, 2007aSmit et al, , 2007bvan Beijsterveldt and van Baal, 2002). Note that genetic contribution to SCP was localized mainly in the right frontal, left parietal-central, and occipital areas, but for upper alpha synchronization and theta desynchronization, no clear topographic pattern in heritability could be distinguished.…”

Section: Discussionmentioning

confidence: 46%

Phenotypic and genetic correlations between evoked EEG/ERP measures during the response anticipation period of a delayed response task

et al. 2009

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We investigated the relationship between three electrophysiological indices of response anticipation in a spatial delayed response task with a low and high memory load manipulation: a slow cortical potential (SCP), theta desynchronization, and upper alpha synchronization. Individual differences in these three measures were examined in 531 adult twins and siblings. Heritability of the SCP at occipital-parietal leads varied from 30% to 43%. Heritability of upper alpha synchronization (35% to 65%) and theta desynchronization (31% to 50%) was significant at all leads. Theta desynchronization and upper alpha synchronization were significantly correlated (r $ 43%), but SCP was not correlated with either. The effect of working memory load on all three measures was not heritable. Response anticipation reliably evokes an SCP, upper alpha synchronization and theta desynchronization, but variation in these measures reflects different (genetic) sources.

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“…For example, we found a wide range of heritability scores for WCST task indicators, 22 which may be due to the poor psychometric properties of indicators like 'the failure to maintain set' variable (h 2 = 0.04), which in most samples shows strong positive skew. Similarly, heritability estimates for the choice RT task reveal an association between h 2 and task difficulty/complexity, with higher h 2 for the more complex eight-choice condition.…”

Section: Discussionmentioning

confidence: 94%

A collaborative knowledge base for cognitive phenomics

et al. 2008

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The human genome project has stimulated development of impressive repositories of biological knowledge at the genomic level and new knowledge bases are rapidly being developed in a 'bottom-up' fashion. In contrast, higher-level phenomics knowledge bases are underdeveloped, particularly with respect to the complex neuropsychiatric syndrome, symptom, cognitive, and neural systems phenotypes widely acknowledged as critical to advance molecular psychiatry research. This gap limits informatics strategies that could improve both the mining and representation of relevant knowledge, and help prioritize phenotypes for new research. Most existing structured knowledge bases also engage a limited set of contributors, and thus fail to leverage recent developments in social collaborative knowledge-building. We developed a collaborative annotation database to enable representation and sharing of empirical information about phenotypes important to neuropsychiatric research (www.Phenowiki.org). As a proof of concept, we focused on findings relevant to 'cognitive control', a neurocognitive construct considered important to multiple neuropsychiatric syndromes. Currently this knowledge base tabulates empirical findings about heritabilities and measurement properties of specific cognitive task and rating scale indicators (n = 449 observations). It is hoped that this new open resource can serve as a starting point that enables broadly collaborative knowledge-building, and help investigators select and prioritize endophenotypes for translational research.

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Genetics, prefrontal cortex, and cognitive control: a twin study of event-related brain potentials in a response inhibition task

Cited by 53 publications

References 22 publications

Genetic Contribution to the P3 in Young and Middle-Aged Adults

Genetic Contribution to the P3 in Young and Middle-Aged Adults

Phenotypic and genetic correlations between evoked EEG/ERP measures during the response anticipation period of a delayed response task

A collaborative knowledge base for cognitive phenomics

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