Genetics of tension‐type headache: A population based twin study

Russell, Michael Bjørn; Levi, Niels; Kaprio, Jaakko

doi:10.1002/ajmg.b.30497

Cited by 27 publications

(21 citation statements)

References 29 publications

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“…Obesity is a strongly genetic trait, with heritability estimates ranging from 50 – 80% in twin studies 48. Genetic influences have also been reported for most of the pain diagnoses and symptoms examined in this study, with heritability estimates ranging from 25% for irritable bowel syndrome to 45% for fibromyalgia, and up to 68% for back pain 5, 11, 17, 38, 40, 43, 44, 51, 55.…”

Section: Discussionsupporting

confidence: 51%

Chronic Pain, Overweight, and Obesity: Findings from a Community-Based Twin Registry

Wright

Schur

Noonan

et al. 2010

The Journal of Pain

163

134

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Chronic pain and obesity, and their associated impairments, are major health concerns. We estimated the association of overweight and obesity with five distinct pain conditions and three pain symptoms, and examined whether familial influences explained these relationships. We used data collected from 3,471 twins in the community-based University of Washington Twin Registry. Twins reported sociodemographic data, current height and weight, chronic pain diagnoses and symptoms, and lifetime depression. Overweight and obese were defined as body mass index of 25.0 -29.9 kg/m 2 and ≥ 30.0 kg/m 2 , respectively. Generalized estimating equation regression models, adjusted for age, gender, depression, and familial/genetic factors were used to examine the relationship between chronic pain, and overweight and obesity. Overall, overweight and obese twins were more likely to report low back pain, tension-type or migraine headache, fibromyalgia, abdominal pain, and chronic widespread pain than normal weight twins after adjustment for age, gender, and depression. After further adjusting for familial influences, these associations were diminished. The mechanisms underlying these relationships are likely diverse and multifactorial, yet this study demonstrates that the associations can be partially explained by familial and sociodemographic factors, and depression. Future longitudinal research can help to determine causality and underlying mechanisms. KeywordsChronic Pain; Genetics; Heritability; Obesity; Twins Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. PERSPECTIVE This article reports on the familial contribution and the role of psychological factors in the relationship between chronic pain, and overweight and obesity. These findings can increase our understanding of the mechanisms underlying these two commonly comorbid sets of conditions. NIH Public Access

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Section: Discussionsupporting

confidence: 51%

Chronic Pain, Overweight, and Obesity: Findings from a Community-Based Twin Registry

Wright

Schur

Noonan

et al. 2010

The Journal of Pain

163

134

View full text Add to dashboard Cite

show abstract

“…IL-1β and IL-18 are typically released in response to tissue injury or pathogen infection, which has not been demonstrably implicated in cases of CTTH. However, family studies have shown that genetic factors are important in the etiology of CTTH (33). We hypothesized that genetic changes may be responsible for the observed increase in IL-1β expression observed in CTTH individuals.…”

Section: Discussionmentioning

confidence: 96%

Peripheral Interleukin‐1β Levels are Elevated in Chronic Tension‐Type Headache Patients

Vedova

Cathcart

Dohnalek

et al. 2013

Pain Research and Management

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BACKGROUND: Tension-type headache is the most common form of headache and its chronic form, chronic tension-type headache (CTTH), is one of the most difficult to treat. The etiology of CTTH is not well understood, but is believed to be multifactorial and to vary among individuals. In the present study, the authors sought to identify common mechanisms of CTTH pathology. Empirical studies have implicated various immunomodulatory cytokines as mediators of chronic pain disorders, including CTTH.OBJECTIVES: To determine the role of peripheral cytokines and genetic factors in the development of CTTH.METHODS: A panel of cytokines hypothesized to play a role in the pathogenesis of CTTH was measured using cytometric bead arrays and ELISAs in 56 individuals with CTTH and 42 healthy control participants between 18 and 65 years of age.RESULTS: Levels of interleukin (IL)-1β were significantly elevated in participants diagnosed with CTTH relative to healthy controls, while IL-18 levels were found to be significantly elevated in men with CTTH. Because the levels of these immune mediators were increased in the apparent absence of injury or infection, the authors sought to determine whether genetic changes were responsible for fluctuations in cytokine levels. Polymerase chain reaction and restriction fragment length polymorphism analyses were used to determine individual genotypes at key single nucleotide polymorphism positions in theIL-1Bgene. No association was observed between CTTH and single nucleotide polymorphisms in the IL-1β gene.CONCLUSIONS: These findings suggest that increases in key proinflammatory cytokine levels are associated with CTTH and the pathology of the disorder involves sterile neurovascular inflammation.

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“…Tension-type headache has been examined in three studies (20,26,27 (migraine excluded), reporting heritability of 48% for men and 44% for women (26). The latter study is the largest, including more than 7000 pairs and is likely to be the most accurate estimate for adults.…”

Section: Headachesmentioning

confidence: 99%

Twin studies of pain

2012

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Twin studies provide a method for estimating the heritability of phenotypes and for examining genetic and environmental relationships between phenotypes. We conducted a systematic review of twin studies of pain, including both clinical and experimental pain phenotypes. Fifty-six papers were included, whereof 52 addressed clinical phenotypes. Of the most comprehensively studied phenotypes, available data indicates heritability around 50% for migraine, tension-type headache and chronic widespread pain, around 35% for back and neck pain, and around 25% for irritable bowel syndrome. However, differences in phenotype definitions make these results somewhat uncertain. All clinical studies relied on dichotomous outcomes and none used pain intensity as continuous phenotype. This is a major weakness of the reviewed studies and gives reason to question their validity with respect to pain mechanisms. Experimental pain studies indicate large differences in heritability across pain modalities. Whereas there is evidence for substantial common genetic risk across many clinical pain conditions, different experimental pain phenotypes appear to be associated with different genetic factors. Recommendations for future research include inclusion of pain intensity scaling and number of pain sites in phenotyping. Furthermore, studies examining the genetic relationships between pain phenotypes, in particular between clinical and experimental phenotypes, should be prioritized.

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Genetics of tension‐type headache: A population based twin study

Cited by 27 publications

References 29 publications

Chronic Pain, Overweight, and Obesity: Findings from a Community-Based Twin Registry

Chronic Pain, Overweight, and Obesity: Findings from a Community-Based Twin Registry

Peripheral Interleukin‐1β Levels are Elevated in Chronic Tension‐Type Headache Patients

Twin studies of pain

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