Genetics of T2DM and Its Chronic Complications: Are We Any Closer to the Individual Prediction of Genetic Risk?
D. Galuška,
Lucie Dlouhá,
J. A. Hubáček
et al.
Abstract:Type 2 diabetes mellitus (T2DM) is a complex disease that has risen in global prevalence over recent decades, resulting in concomitant and enormous socio-economic impacts. In addition to the well-documented risk factors of obesity, poor dietary habits and sedentary lifestyles, genetic background plays a key role in the aetiopathogenesis of diabetes and the development of associated micro- and macro-vascular complications. Recent advances in genomic research, notably next-generation sequencing and genome-wide a… Show more
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