Genetics of susceptibility for radiation-induced leukemia. Mapping of genes involved to chromosomes 1, 2, and 4, and implications for a viral etiology in the disease.

Meruelo, Daniel; Offer, Miriam; Flieger, N

doi:10.1084/jem.154.4.1201

Cited by 33 publications

(9 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on this apparent linkage between Ly-6 and Ly-li, they mapped Ly-6 to a position on chromosome 2. Evidence was also presented for a linkage of Ly-6 to a locus influencing susceptibility to radiation-induced leukemia, Ril-i (27), and to the minor histocompatibility locus H-30, which were both assigned to chromosome 2 (16). Further examinations of this and other work has led to a reevaluation of these chromosomal assignments.…”

Section: Discussionmentioning

confidence: 99%

“…The duplication of the distal portion of chromosome 15 was frequently associated with the occurrence of T-cell leukemias (36, 37). As mentioned above, the major locus influencing susceptibility to leukemia induction by fractionated irradiation, Ril-i, has been remapped to a position on chromosome 15, closely linked to the Ly-6 locus (27,38). As indicated in Fig.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Murine Ly-6 multigene family is located on chromosome 15.

LeClair¹,

Rabin²,

Nesbitt³

et al. 1987

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Murine Ly-6-encoded molecules play an important role in the antigen-independent activation of lymphocytes. We have described the cloning of a cDNA encoding the protein component of an Ly-6 molecule. Hybridization studies indicated that this cDNA identified multiple DNA fragments on Southern blots. The banding pattern exhibits a restriction fragment length polymorphism from mice bearing either the Ly-6a or the Ly-6b allele. We have employed three independent chromosomal mapping techniques, somatic cell hybrids, in situ hybridization, and strain distribution pattern analysis of the restriction fragment length polymorphism of DNA from recombinant inbred lines, to ascertain the chromosomal origins of these bands. We report that all members of the Ly-6 multigene family are tightly linked on chromosome 15 and have been regionalized by in situ hybridization analysis to band 15E on the distal portion of this chromosome. Linkage analysis has indicated that the Ly-6 genes are located within 1 map unit of Env-54 (a retroviral envelope restriction fragment length polymorphism probe), 3 map units from ins-1, (insulin-related gene), and 4 map units from the protooncogene c-sis. The possible involvement of the Ly-6 lymphocyte activation and differentiation antigen genes in chromosome 15-related lymphoid malignancies is discussed.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Murine Ly-6 multigene family is located on chromosome 15.

LeClair¹,

Rabin²,

Nesbitt³

et al. 1987

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…Analysis of malignant cells bearing lp abnormalities may reveal alterations in Ick expression as is the case in the murine lymphomas LSTRA and Thy-19. Similarly, it is provocative that one of three loci conferring susceptibility to radiationinduced leukemia in mice (Ril-3) has been localized to distal murine chromosome 4 (42). In contrast, the Ick locus is clearly distinct from the tcl-J [(14q32.3), (43) An additional oncogene, N-ras (lpll-13), has also been localized on the short arm of human chromosome 1 (51).…”

Section: The Lkk Gene Is Located In a Region Of Synteny Betweenmentioning

confidence: 99%

Localization of a lymphocyte-specific protein tyrosine kinase gene (lck) at a site of frequent chromosomal abnormalities in human lymphomas.

Marth

Pravtcheva

Ruddle³

et al. 1986

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

The murine Ick gene is closely related to a family of cellular protooncogenes and encodes a lymphocytespecific, membrane-associated protein tyrosine kinase. We and others have demonstrated that the Ick gene is rearranged and overexpressed in the murine lymphoma LSTRA, most likely as a result of the insertion of Moloney murine leukemia virus DNA immediately adjacent to the gene. We now report that the Ick gene is located at the distal end of murine chromosome 4 and on human chromosome 1 at position lp32-35 near a site of frequent structural abnormalities in human lymphomas and neuroblastomas. These results raise the possibility that structural alteration of the ick gene through chromosomal rearrangement may contribute to transformation in human malignant disease.At least twelve genes encoding protein tyrosine kinases have been implicated in neoplastic transformation in mammalian cells (1, 2). Broadly speaking, characterized protein tyrosine kinase genes can be divided into two subfamilies. The first -encodes a group of cell-surface receptors that mediate mitogenesis. Ligands for these receptors are in three cases known, the epidermal growth factor (EGF) receptor (3), the insulin receptor (4), and the colony-stimulating factor 1 (CSF-1) receptor (5), while two other members of this subfamily encode receptor structures for which ligands are at present unidentified, neu (6, 7) and trk (8). A second subfamily of protein tyrosine kinase genes encodes a group of proteins that are typically membrane-associated but which lack recognizable transmembrane domains, for example abl, fgr, src, and lck** (1, 2, 9, 10). The protein tyrosine kinase oncogenes were originally identified as components of acutely transforming retroviruses or through transformation of cultured fibroblasts via transfection of tumor DNA (1, 2). In at least one case, the t(9;22) translocation of human chronic myelogenous leukemia, activation of a protein tyrosine kinase protooncogene (abi) results from a spontaneous chromosomal rearrangement (11,12). Thus protein tyrosine kinases may in some cases be involved in the specific chromosomal abnormalities frequently detected in human and murine neoplasia.The murine Ick gene encodes a lymphocyte-specific, membrane-associated protein tyrosine kinase of unknown function. We and others have demonstrated that this gene is rearranged and overexpressed in the murine lymphoma LSTRA, most likely as a result of insertion of Moloney murine leukemia virus sequences immediately upstream of the gene (9, 10). We now report that the Ick gene is located on human chromosome 1 at position 1p32-35 in a site of frequent structural abnormalities in human lymphomas and neuroblastomas. These results suggest that structural alteration of the lck gene through chromosomal rearrangement may occasionally contribute to transformation in human malignant disease. (14). Hybridization of the lck probe to mitotic chromosomes was performed by a modification of the method of Harper and Saunders (15). Briefly, chromosome slide preparatio...

show abstract

“…There are many di erent inbred mouse strains that show variation in cancer susceptibility. For instance, BALB/ c is a susceptible strain to the development of thymic lymphoma after exposure to g-ray radiation (Meruelo et al, 1981;Okumoto et al, 1990) while MSM, an inbred strain derived from Japanese wild mice, Mus musculus molossinus, shows resistance (Matsumoto et al, 1998). Crossing of the sensitive and resistant strains may provide valuable information about the number of genes involved, their approximate locations, and the dominant or recessive nature of the susceptibility.…”

mentioning

confidence: 99%

Genetic loci controlling susceptibility to γ-ray-induced thymic lymphoma

et al. 2001

View full text Add to dashboard Cite

is a susceptible strain for the development of gray induced mouse thymic lymphoma whereas MSM shows resistance. Association analysis of 220 backcross mice between the two strains using 67 markers was carried out to identify loci involved in the control of susceptibility. The genotype of mice with lymphoma showed excess heterozygosity relative to MSM homozygosity at D2Mit15 and D4Mit12 and was skewed toward MSM-derived alleles at D5Mit5. The P values in Mantel-Cox test were 0.0048 (D2Mit15), 0.0034 (D4Mit12) and 0.0048 (D5Mit5), suggesting association at the three loci in the susceptibility. Cooperative e ect on lymphomagenesis was also observed among the three loci. To obtain independent evidence for linkage at D4Mit12, we made partially congenic mice in which a D4Mit12 region in BALB/c was replaced by MSMderived homolog. Examination for the lymphoma susceptibility in 78 progeny of the congenic mice con®rmed the e ect of the locus near D4Mit12 (P=0.0037). The result, together with the linkage analysis, shows that the locus near D4Mit12 is regarded as a con®rmed linkage but the other two loci as marginally suggestive. Oncogene (2001) 20, 5243 ± 5247.

show abstract

Genetics of susceptibility for radiation-induced leukemia. Mapping of genes involved to chromosomes 1, 2, and 4, and implications for a viral etiology in the disease.

Cited by 33 publications

References 29 publications

Murine Ly-6 multigene family is located on chromosome 15.

Murine Ly-6 multigene family is located on chromosome 15.

Localization of a lymphocyte-specific protein tyrosine kinase gene (lck) at a site of frequent chromosomal abnormalities in human lymphomas.

Genetic loci controlling susceptibility to γ-ray-induced thymic lymphoma

Contact Info

Product

Resources

About