Genetics of social anxiety disorder: a systematic review

Baba, Ami; Kloiber, Stefan; Zai, Gwyneth

doi:10.1097/ypg.0000000000000310

Cited by 5 publications

(2 citation statements)

References 98 publications

(209 reference statements)

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“…A systematic review provided strong evidence of interactions between FKBP5 genotypes and early-life stress, which could pose a significant risk for stress-associated neuropsychological disorders (e.g., depression and PTSD) [ 25 ]. Previous studies have also implicated a strong genetic architecture for anxiety disorders [ 27 ]. One study suggested that hypermethylation of a discrete region located within the SLC6A4 promoter region in women could underlie differential serotonin transporter (SERT) expression in women compared with in men; this could be one of the underlying pathological underpinnings through which women show increased prevalence of somatization [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Genetics of Functional Seizures; A Scoping Systematic Review

Asadi-Pooya,

Hallett,

Mirzaei Damabi

et al. 2023

Genes

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Background: Evidence on the genetics of functional seizures is scarce, and the purpose of the current scoping systematic review is to examine the existing evidence and propose how to advance the field. Methods: Web of science and MEDLINE were searched, from their initiation until May 2023. The following key words were used: functional neurological disorder(s), psychogenic neurological disorder(s), functional movement disorder(s), psychogenic movement disorder(s), functional seizures(s), psychogenic seizure(s), nonepileptic seizure(s), dissociative seizure(s), or psychogenic nonepileptic seizure(s), AND, gene, genetic(s), polymorphism, genome, epigenetics, copy number variant, copy number variation(s), whole exome sequencing, or next-generation sequencing. Results: We identified three original studies. In one study, the authors observed that six (5.9%) patients with functional seizures carried pathogenic/likely pathogenic variants. In another study, the authors observed that, in functional seizures, there was a significant correlation with genes that are over-represented in adrenergic, serotonergic, oxytocin, opioid, and GABA receptor signaling pathways. In the third study, the authors observed that patients with functional seizures, as well as patients with depression, had significantly different genotypes in FKBP5 single nucleotide polymorphisms compared with controls. Conclusion: Future genetic investigations of patients with functional seizures would increase our understanding of the pathophysiological and neurobiological problems underlying this common neuropsychological stress-associated condition.

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Section: Discussionmentioning

confidence: 99%

Genetics of Functional Seizures; A Scoping Systematic Review

Asadi-Pooya,

Hallett,

Mirzaei Damabi

et al. 2023

Genes

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“…In terms of genetics, the number of studies on the role of various genetic origins for anxiety disorders are rapidly increasing. Albeit specific genes have yet to be consistently identified, recent reviews of the genetics of anxiety disorders recommend including genetics and biomarkers as predictors in treatment studies (Baba et al, 2022;Tomasi et al, 2019). In terms of attachment and social functioning, measures range from observation paradigms to parent and self-report measures of both direct attachment but also related concepts such as emotional relations and/or communication.…”

Section: Implications and Concluding Remarksmentioning

confidence: 99%

Anxiety Symptom Trajectories Predict Depression Symptom Trajectories up to Four Years After CBT for Youth Anxiety Disorders

Fjermestad,

Norum,

Brask

et al. 2024

Res Child Adolesc Psychopathol

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Long-term data on depression symptoms after cognitive behavioral therapy (CBT) for youth anxiety disorders are scant. We examined depression symptoms up to four years post CBT for anxiety addressing youth age and gender, family social class, and parent mental health as predictors. The sample comprised 179 youth (M age at pre-treatment = 11.5 years; SD = 2.1) in a randomized controlled trial. Clinically assessed anxiety diagnoses and youth and parent-reported anxiety and depression symptoms were measured before, after, and one and four years after CBT. Parent self-reported mental health was measured before CBT. We used regression analyses to determine whether full diagnostic recovery at post-CBT predicted depression trajectories across the four-year assessment period. We used growth curve models to determine whether anxiety trajectories predicted depression trajectories across the four-year assessment period. Youth who lost their anxiety diagnoses after CBT had significantly lower parent-reported depression levels over time, but not lower youth self-reported depression levels. The anxiety symptom trajectory predicted the depression symptom trajectory up to four years post-treatment. There was more explained variance for within-informant (youth-youth; parent-parent) than cross-informants. Being older, female, having lower socio-economic status and parents with poorer mental health were associated with more youth-rated depression over time. However, these demographic predictors were not significant when anxiety symptoms trajectories were added to the models. Successful CBT for anxiety in children is associated with less depression symptoms for as long as four years. Anxiety symptom improvement appears to be a stronger predictor that demographic variables and parent mental health.

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Social anxiety, voice confrontation and voice recognition: A bilingual exploration

Jogia,

Thomas,

Barbato

et al. 2024

Int J Psychol

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Many people dislike the sound of their voices, especially when listening back to audio recordings (voice confrontation). Previous research reports that disliking the sound of one's voice is associated with elevated levels of social anxiety. The present study investigated the relationship between social anxiety and voice dislike and voice misrecognition among a bilingual population: Arabic (L1) and English (L2). Participants (N = 176) completed self‐report measures of social anxiety and own voice liking. Additionally, they performed a novel own voice recognition task, assessing their ability to recognise a recording of their voice, differentiating it from digitally altered versions of the same recording. Social anxiety symptomatology was associated with disliking the sound of one's voice, with a larger effect for L1 than L2. Social anxiety was also associated with own voice misrecognition, but only for L1. Highly negative evaluations about the sound of one's voice may represent a vulnerability for social anxiety disorder.

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Genetics of social anxiety disorder: a systematic review

Cited by 5 publications

References 98 publications

Genetics of Functional Seizures; A Scoping Systematic Review

Genetics of Functional Seizures; A Scoping Systematic Review

Anxiety Symptom Trajectories Predict Depression Symptom Trajectories up to Four Years After CBT for Youth Anxiety Disorders

Social anxiety, voice confrontation and voice recognition: A bilingual exploration

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