Genetics of Resistance of Animals to Viruses: I. Introduction and Studies in Mice

Bang, Frederik B.

doi:10.1016/s0065-3527(08)60102-5

Cited by 50 publications

(25 citation statements)

References 210 publications

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“…Because of the characteristic disease picture seen with each strain of MHV, several investigators are utilizing variants or mutants to elucidate the mechanisms of virus replication, viral nucleic acid and capsid protein structure, and virus-host in teractions that result in different expressions of disease by very closely related agents (see, e.g., Haspel etaL, 1978;Bond et aL, 1979). Bang (1978) has addressed the genetics of resistance of mice to murine Coronavirus infection.…”

Section: A Historical Backgroundmentioning

confidence: 99%

Viral Diseases of the Digestive System

Kraft¹

1982

Diseases

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Section: A Historical Backgroundmentioning

confidence: 99%

Viral Diseases of the Digestive System

Kraft¹

1982

Diseases

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“…Neonatal mice are highly susceptible to respiratory MHV strains, and usually succumb to disseminated infections with hepatitis and/or encephalitis. Disease susceptibility generally correlates with virus titer in various target organs following infection with respiratory MHV strains (Bang 1978;Barthold and Smith 1987;Hirano, Takenaka, et al 1975;Suzuki et al 1997;Taguchi et al 1979b). Resistance to respiratory MHV increases at around 2 weeks of age, with significant differences in susceptibility among older mice, depending upon genotype Hirano, Takenaka, et al 1975;Suzuki et al 1997;Taguchi et al 1979b).…”

Section: A Pathogenesis Of Respiratory and Enterotropic Mhvmentioning

confidence: 99%

Mouse Hepatitis Virus

Barthold¹,

Smith²

2007

The Mouse in Biomedical Research

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“…Certainly, it is important to establish model systems that examine the significance of the genetics of host-pathogen relationships [18][19][20]. It is meaningless to talk about pathogen virulence or host resistance as separate entities without reference to a particular host or agent.…”

Section: Need For Clearly Defined Model Systemsmentioning

confidence: 99%

Micronutrients and Infectious Diseases: Thoughts on Integration of Mechanistic Approaches into Micronutrient Research

Taylor

Higgs

2000

J INFECT DIS

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Results of field and laboratory studies provide convincing evidence that micronutrient deficiencies contribute to the mortality and morbidity of infectious diseases. Despite encouraging results in large trials, understanding the mechanisms by which micronutrients contribute to the outcome of the encounter between an individual and an infectious agent requires additional hypothesis-driven research. Presumably, such understanding should lead to translational studies with targeted nutritional therapy. Although these mechanistic studies are varied and complex, they must be done systematically and should include examination of the mechanisms by which micronutrients affect host-pathogen interactions, development of appropriate animal models and reliable methods for the assessment of micronutrient levels, and translation of the results of basic research findings into clinical studies. Moving the frontiers of micronutrient research from the laboratory to the field will be challenging. However, sound scientific research should lead toward better human health.

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Genetics of Resistance of Animals to Viruses: I. Introduction and Studies in Mice

Cited by 50 publications

References 210 publications

Viral Diseases of the Digestive System

Viral Diseases of the Digestive System

Mouse Hepatitis Virus

Micronutrients and Infectious Diseases: Thoughts on Integration of Mechanistic Approaches into Micronutrient Research

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