Genetics of osteoporosis in Chinese

Abstract

Osteoporosis is a common skeletal disease characterized by low bone mineral density (BMD) and deterioration in bone microarchitecture, resulting in increased bone fragility and susceptibility to fractures. As a complex disease, it is determined by both genetic and environmental factors, as well as their interactive effects. Studies have suggested that different genetic determinants may be involved in different ethnic groups. In this paper, we reviewed the genetic studies of osteoporosis in A Chinese population, focusing on the genes affecting BMD, a surrogate phenotype of osteoporosis.

Osteocalcin Gene Polymorphism in Indonesian Men With Periodontitis

“…However, in combination with other OC polymorphisms and associated proteins (including RANK and RANKL), more significant associations could be explored in addition to increasing the sample size. Contradictory results regarding the association of OC with BMD are not uncommon [13][14][15][16][17][18]. In general, the tested populations show a roughly similar distribution of the OC C298T polymorphism, with the HH genotype being the least common polymorphism; [15][16][17][18][19][20] this was also the case in the present study.…”

“…Contradictory results regarding the association of OC with BMD are not uncommon [13][14][15][16][17][18]. In general, the tested populations show a roughly similar distribution of the OC C298T polymorphism, with the HH genotype being the least common polymorphism; [15][16][17][18][19][20] this was also the case in the present study. As a single polymorphism of a single gene may only show a weak association with a condition of interest, a stronger association has been explored using combinations of potential indicators [21][22][23].…”