Genetics of Interracial Crosses in Hawaii

Ne, Morton; Cs, Chung; Mp, Mi

doi:10.1159/isbn.978-3-318-03995-5

Cited by 97 publications

(36 citation statements)

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“…However, Korean mothers have a normal sex ratio among their progeny, ruling out effects of sexdifferential mortality in utero [Morton et al, 1967].…”

Section: Discussionmentioning

confidence: 99%

Sex Ratio and Proportion of Affected Sons in Sibships with X-Chromosomal Recessive Traits: Maximum Likelihood Estimation in Truncated Multinomial Distributions

Fellman¹,

Eriksson²,

Forsius³

2002

Hum Hered

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If mothers are carriers of a recessive male sex-linked disorder, their children may include females, healthy males and affected males. The composition of the possible sibships follows a multinomial distribution. If the mothers are diagnosed as carriers independently of their offspring, then the distributions are not truncated, but if they are classified as carriers after the birth of at least one affected son, the distributions are truncated. In order to avoid ascertainment bias, the statistical analyses of the corresponding data must differ. We present procedures for estimation in both the untruncated and the truncated case. The formulae obtained are applied to family data for X-chromosomal recessive retinoschisis (RS) from the region of Satakunta in southwestern Finland. Earlier studies indicated that, among the offspring of RS carriers, the sex ratio was increased. In our model, therefore, we include both the proportion of males and the proportion of affected individuals among the males. The sex ratio was significantly increased (131.0), but the proportion of affected males was slightly lower than expected (42.5%). RS seems to be the only known genetic disorder in which the offspring of carriers of the mutation include a statistically significant surplus of males.

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“…However, Korean mothers have a normal sex ratio among their progeny, ruling out effects of sexdifferential mortality in utero [Morton et al, 1967].…”

Section: Discussionmentioning

confidence: 99%

Sex Ratio and Proportion of Affected Sons in Sibships with X-Chromosomal Recessive Traits: Maximum Likelihood Estimation in Truncated Multinomial Distributions

Fellman¹,

Eriksson²,

Forsius³

2002

Hum Hered

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“…If -y is the proportion of suspects who are guilty, the conditional probability that the suspect is the culprit, given a match with probability Ck, is V Y + (1 y)Ck' [16] (18).…”

Section: Models For Mikmentioning

confidence: 99%

Genetic structure of forensic populations.

Morton

1992

Proc. Natl. Acad. Sci. U.S.A.

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“…[1967J. The information on Lhe above variables was derived from birth certificates. The definitions of maternal illness and abnormal labor arc given in Morton et al [1967]. The method of analysis was the stepwise regression within racial groups by assigning Y = 1 to TEV probands and Y = 0 for normal individuals, and regressing Y on the variables mentioned above.…”

Section: Maternal and Other Factorsmentioning

confidence: 99%

“…It has been reported that the incidence of 'clubfoot' is higher among Hawaiian descendants than among other racial groups in Hawaii [Stewart, 1951;Morton, Chung, and Mi, 1967]. In addition to the indicated racial variation in the incidence, the following favorable conditions in Hawaii have led to an intensive investigation of TEV by the University of Hawaii in close collabora tion with the Honolulu Shriners' Hospital for Crippled Children.…”

mentioning

confidence: 99%

“…In addition to the indicated racial variation in the incidence, the following favorable conditions in Hawaii have led to an intensive investigation of TEV by the University of Hawaii in close collabora tion with the Honolulu Shriners' Hospital for Crippled Children. They are: (1) Racial background of the population is diverse, (2) Many races are represented by substantial numbers, (3) Interracial crosses of different types are frequent, (4) Socio-economic status of different racial groups are relatively uniform, (5) Level of medical care is high, (6) The population is relatively confined because of its geographical location, and (7) Genetic aspect of the base population has been well studied [Morton et al, 1967].…”

mentioning

confidence: 99%

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