Genetics of gestational trophoblastic disease

Fisher, Rosemary A.; Maher, Geoffrey J.

doi:10.1016/j.bpobgyn.2021.01.004

Cited by 34 publications

(46 citation statements)

References 88 publications

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“…[14][15][16]. If FRHM is confirmed, egg donation from an unaffected individual is a way to enable a successful non-molar pregnancy [17].…”

Section: Molar Pregnancymentioning

confidence: 99%

“…The use of sensitive hCG assays and early ultrasound have shifted detection of molar pregnancy into the first trimester and therefore the classic presenting symptoms (excessive uterine size, anemia, preeclampsia, hyperemesis, hyperthyroidism, and respiratory failure) are rarely encountered [21][22][23][24]. This shift to earlier detection and evacuation has necessitated the use of additional diagnostics such as flow cytometry to determine ploidy, and immunohistochemistry staining for the cyclin dependent kinase inhibitor, p57 [17]. As a paternally imprinted and maternally expressed gene, p57 can differentiate between CM (p57 negative) and either a PM (p57 positive) or nonmolar hydropic abortions [25].…”

Section: Molar Pregnancymentioning

confidence: 99%

See 1 more Smart Citation

Epidemiology, diagnosis, and treatment of gestational trophoblastic disease: A Society of Gynecologic Oncology evidenced-based review and recommendation

Horowitz

Eskander

Adelman

et al. 2021

Gynecologic Oncology

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“…[14][15][16]. If FRHM is confirmed, egg donation from an unaffected individual is a way to enable a successful non-molar pregnancy [17].…”

Section: Molar Pregnancymentioning

confidence: 99%

Section: Molar Pregnancymentioning

confidence: 99%

Epidemiology, diagnosis, and treatment of gestational trophoblastic disease: A Society of Gynecologic Oncology evidenced-based review and recommendation

Horowitz

Eskander

Adelman

et al. 2021

Gynecologic Oncology

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“…Gestational trophoblastic disease, especially hydatidiform mole, is thought to be associated with empty oocyte fertilization or polyspermy [17,18]. In this retrospective cohort study of 176 patients undergoing IVF/ICSI cycles for infertility, a history of GTD was associated with embryologic outcomes, including a higher ratio of ICSI/ PGT cycles, fewer good-quality embryos and more abandoned embryos, but it did not statistically impact the fertilization rate or normal fertilization rate.…”

Section: Discussionmentioning

confidence: 97%

Association between gestational trophoblastic disease (GTD) history and clinical outcomes in in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles

Cai

Zhang

Huang

et al. 2022

Reprod Biol Endocrinol

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Background Gestational trophoblastic disease (GTD) usually affects young women of childbearing age. After treatment for GTD, 86% of women wish to achieve pregnancy. On account of the impacts of GTD and treatments as well as patient anxiety, large numbers of couples turn to assisted reproductive technology (ART), especially in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). But few studies have investigated whether a history of GTD affects the outcomes of IVF/ICSI in secondary infertile patients and how it occurs. We investigate whether a history of GTD affects the IVF/ICSI outcomes and the live birth rates in women with secondary infertility. Methods This retrospective cohort study enrolled 176 women with secondary infertility who underwent IVF/ICSI treatment at the reproductive medical center of Nanjing Drum Tower Hospital from January 1, 2016, to December 31, 2020. Participants were divided into the GTD group (44 women with GTD history) and control group (132 women without GTD history matched from 8318 secondary infertile women). The control group and the study group were matched at a ratio of 3:1 according to patient age, infertility duration, number of cycles and body mass index (BMI). We assessed retrieved oocytes and high-grade embryos, biochemical pregnancy, miscarriage, ectopic pregnancy, gestational age at delivery, delivery mode and live birth rates. Result(s) We found a significantly reduced live-birth rate (34.1% vs 66.7%) associated with IVF/ICSI cycles in patients with a GTD history compared to those without a GTD history. The biochemical pregnancy and miscarriage rates of the GTD group were slightly higher than those of the control group. In addition, there was a difference in gestational age at delivery between the GTD and control groups (p < 0.001) but no differences in the mode of delivery (p = 0.267). Furthermore, the number of abandoned embryos in the GTD group was greater than that in the control group (p = 0.018), and the number of good-quality embryos was less than that in the control group (p = 0.019). The endometrial thickness was thinner (p < 0.001) in the GTD group. Immunohistochemistry (IHC) showed abnormal endometrial receptivity in the GTD group. Conclusion(s) The GTD history of patients undergoing IVF/ICSI cycles had an impact on the live-birth rate and gestational age at delivery, which might result from the thinner endometrium and abnormal endometrial receptivity before embryo transfer.

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“…In our study, the endometrial thickness of patients with a GTD history was much thinner than that of the control patients. A thin endometrium can result in impaired endometrial receptivity, leading to reduced embryo implantation and pregnancy rates in IVF/ICSI [17].…”

Section: Discussionmentioning

confidence: 99%

Association Between Gestational Trophoblastic Disease (GTD) History and Clinical Outcomes in in Vitro Fertilization/intracytoplasmic Sperm Injection (IVF/ICSI) Cycles

Cai¹,

Zhang²,

Huang³

et al. 2021

Preprint

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Background: Gestational trophoblastic disease (GTD) usually affects young women of childbearing age. After treatment for GTD, 86% of women wish to achieve pregnancy. On account of the impacts of GTD and treatments as well as patient anxiety, large numbers of couples turn to assisted reproductive technology (ART), especially in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). But few studies have investigated whether a history of GTD affects the outcomes of IVF/ICSI in secondary infertile patients and how it occurs. We investigate whether a history of GTD affects the IVF/ICSI outcomes and the live birth rates in women with secondary infertility.Methods: This retrospective cohort study enrolled 176 women with secondary infertility who underwent IVF/ICSI treatment at the reproductive medical center of Nanjing Drum Tower Hospital from January 1, 2016, to December 31, 2020. Participants were divided into the GTD group (44 women with GTD history) and control group (132 women without GTD history matched from 8318 secondary infertile women ). The control group and the study group were matched at a ratio of 3:1 according to patient age, infertility duration, number of cycles and body mass index (BMI). We assessed retrieved oocytes and high-grade embryos, biochemical pregnancy, miscarriage, ectopic pregnancy, gestational age at delivery, delivery mode and live birth rates.Result(s): We found a significantly reduced live-birth rate (34.1% vs 66.7%) associated with IVF/ICSI cycles in patients with a GTD history compared to those without a GTD history. The biochemical pregnancy and miscarriage rates of the GTD group were slightly higher than those of the control group. In addition, there was a difference in gestational age at delivery between the GTD and control groups (p<0.001) but no differences in the mode of delivery (p=0.267). Furthermore, the number of abandoned embryos in the GTD group was greater than that in the control group (p=0.018), and the number of good-quality embryos was less than that in the control group (p=0.019). The endometrial thickness was thinner (p<0.001) in the GTD group. Immunohistochemistry (IHC) showed abnormal endometrial receptivity in the GTD group.Conclusion(s): The GTD history of patients undergoing IVF/ICSI cycles had an impact on the live-birth rate and gestational age at delivery, which might result from the thinner endometrium and abnormal endometrial receptivity before embryo transfer.

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Genetics of gestational trophoblastic disease

Cited by 34 publications

References 88 publications

Epidemiology, diagnosis, and treatment of gestational trophoblastic disease: A Society of Gynecologic Oncology evidenced-based review and recommendation

Epidemiology, diagnosis, and treatment of gestational trophoblastic disease: A Society of Gynecologic Oncology evidenced-based review and recommendation

Association between gestational trophoblastic disease (GTD) history and clinical outcomes in in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles

Association Between Gestational Trophoblastic Disease (GTD) History and Clinical Outcomes in in Vitro Fertilization/intracytoplasmic Sperm Injection (IVF/ICSI) Cycles

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