Genetics of diabetic retinopathy

Simonelli, Francesca; Testa, Francesco; Bandello, Francesco

doi:10.1076/soph.16.1.41.4219

Cited by 4 publications

(1 citation statement)

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“…Furthermore, sub-group analysis in the Diabetes Control and Complications Trial showed strong familial transmission for DR, especially in patients with severe proliferative retinopathy (The Diabetes Control and Complications Trial Research Group 1997). These facts represent convincing evidence that genetic factors contribute to the development of DR, but the genes conferring susceptibility remain to be identified (Simonelli et al 2001;Warpeha and Chakravarthy 2003).…”

Section: Introductionmentioning

confidence: 94%

The relationship between C677T methylenetetrahydrofolate reductase gene polymorphism and retinopathy in type 2 diabetes: a meta-analysis

et al. 2005

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The association between retinopathy in type 2 diabetes [diabetic retinopathy (DR)] and the C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene has been investigated in several case-control studies. These studies rendered contradictory results, some indicating that the polymorphism is associated with the risk of developing DR whereas others concluded there is no association. To shed light on these inconclusive findings, a meta-analysis of all available studies relating the C677T polymorphism to the risk of developing DR was conducted. Four out of five identified studies included populations of East Asian descent, and only one involved samples from European descent (Caucasians). Overall, the meta-analysis suggested large heterogeneity between studies (p = 0.08, I 2 = 52%) and marginal association between C677T transition and the risk of developing DR: random effects odds ratio (OR) = 1. There is a source of bias in the selected studies: the largest studies failed to show association while the smallest study claimed an association. The above findings reinforce the need for larger and more rigourous studies in this area.

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Section: Introductionmentioning

confidence: 94%