2013
DOI: 10.1590/0102-311xpe011113
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Genetics of complex diseases: knowing gene polymorphisms do matter

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“…The use of popular case-control designs to test candidate genes or genome-wide association studies have proved suitable to pinpoint functional genetic variants in complex diseases [ 66 ]. Sometimes it is necessary to test several independent population to replicate the data, but results could be useful to envisage better diagnostics and prognostics methods [ 66 , 67 ]. TB used to be a chronic disease and it is likely that a subtle balance of immune response could have a great impact over its control and progression.…”
Section: Discussionmentioning
confidence: 99%
“…The use of popular case-control designs to test candidate genes or genome-wide association studies have proved suitable to pinpoint functional genetic variants in complex diseases [ 66 ]. Sometimes it is necessary to test several independent population to replicate the data, but results could be useful to envisage better diagnostics and prognostics methods [ 66 , 67 ]. TB used to be a chronic disease and it is likely that a subtle balance of immune response could have a great impact over its control and progression.…”
Section: Discussionmentioning
confidence: 99%