Genetics of Candida albicans.

Scherer, Stewart; Magee, Patrick

doi:10.1128/mmbr.54.3.226-241.1990

Cited by 135 publications

(73 citation statements)

References 100 publications

(146 reference statements)

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“…Heterologous expression of C. albicans UBI3 gene in S. cerevisiae ubi3 cells complements the mutant phenotype Most C. albicans genes are functional in S. cerevisiae and can frequently be expressed directly in this species (Kurtz et al, 1990;Scherer and Magee, 1990;Maneu et al, 2000). Therefore, to determine the function of the C. albicans UBI3 gene, pPR3 was transformed into a S. cerevisiae ubi3 mutant, and the phenotype of the transformants was analysed.…”

Section: Dna and Deduced Amino Acid Sequencesmentioning

confidence: 99%

Molecular cloning and characterization of theCandida albicansUBI3 gene coding for a ubiquitin-hybrid protein

Roig

Martinez

Gil

et al. 2000

Yeast

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Section: Dna and Deduced Amino Acid Sequencesmentioning

confidence: 99%

Molecular cloning and characterization of theCandida albicansUBI3 gene coding for a ubiquitin-hybrid protein

Roig

Martinez

Gil

et al. 2000

Yeast

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“…Although the component(s) of serum that is mainly responsible for the induction of the morphological change is not yet known, serum seems to induce the morphological change in C. albicans through a Ras-mediated signal transduction pathway [4]. The detailed signaling pathways for the seruminduced morphogenesis are still poorly understood in C. albicans because its diploid nature and unknown sexual cycle have hampered the isolation of morphological mutants and the genetic analysis of the mutants [5].…”

Section: Introductionmentioning

confidence: 99%

Serum-induced hypha formation in the dimorphic yeast Yarrowia lipolytica

Kim

2000

FEMS Microbiology Letters

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The dimorphic yeast Yarrowia lipolytica forms true hyphae in a medium containing N-acetylglucosamine. We made a new finding that serum is a very effective inducer of hypha formation of Y. lipolytica: serum induced its hyphal growth very quickly compared to Nacetylglucosamine (4 h vs. 10 h). Osmotic and oxidative stresses (0.2 M NaCl and 20 mM H 2 O 2 ) inhibited the hypha formation induced by N-acetylglucosamine, but did not suppress the hypha formation triggered by serum. Serum-specific morphological mutants, which formed hyphae in the N-acetylglucosamine medium but not in serum medium, could be isolated. These results suggest that the signal triggered by serum may be transduced through a different pathway, at least in part, from that used for the N-acetylglucosamine signal in Y. lipolytica. ß

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“…Tel. : + 1 (202) 687 1136; Fax: + 1 (202) 687 1800, e-mail: rcihla0l@gumedlib.dml.georgetown.edu lence, as well as towards understanding the basic biology of the organism, has occurred [6,7].…”

Section: Introductionmentioning

confidence: 99%

Avirulence of Candida albicans auxotrophic mutants in a rat model of oropharyngeal candidiasis

Cole

1995

FEMS Microbiology Letters

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The virulence of Candida albicans strain SC5413 and two isogenic derivatives have been investigated in a rat model of oropharyngeal candidiasis. The results demonstrate that both mutant strains are avirulent in this animal model while the parental strain readily initiates infection. Avirulence is not related to altered growth characteristics or the inability of the strains to undergo yeast-to-hyphal morphogenesis. The potential importance of nutritional sufficiency as a virulence factor as well as the possibility of utilizing such strains in the development of an in vitro expression technology system for Candida albicans is discussed.

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Genetics of Candida albicans.

Cited by 135 publications

References 100 publications

Molecular cloning and characterization of theCandida albicansUBI3 gene coding for a ubiquitin-hybrid protein

Molecular cloning and characterization of theCandida albicansUBI3 gene coding for a ubiquitin-hybrid protein

Serum-induced hypha formation in the dimorphic yeast Yarrowia lipolytica

Avirulence of Candida albicans auxotrophic mutants in a rat model of oropharyngeal candidiasis

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