Genetics of Behçet’s Disease

Gül, Ahmet; Ohno, Shigeaki

doi:10.1007/978-1-4419-5641-5_15

Cited by 6 publications

(2 citation statements)

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“…The etiology of the disease is unknown; however, both genetic and environmental factors have been implicated in its pathogenesis. Occasional familial occurrence [ 11 ], genetic distribution along the ancient Silk Road, and an association with HLA-B51 are some of the factors pointing toward genetic involvement [ 12 , 13 ]. Environmental conditions, such as bacterial or viral infections, are thought to trigger the disease in genetically susceptible individuals [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Methylation Status of Alu and LINE-1 Interspersed Repetitive Sequences in Behcet’s Disease Patients

Yüksel

Kucukazman²,

Karataş³

et al. 2016

BioMed Research International

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Behcet's Disease (BD) is a multisystem chronic inflammatory disease. The pathology is believed to involve both genetic susceptibility and environmental factors. Hypomethylation leading to activation of interspersed repetitive sequences (IRSs) such as LINE-1 and Alu contributes to the pathologies of autoimmune diseases and cancer. Herein, the epigenetic changes of IRSs in BD were evaluated using combined bisulfite restriction analysis-interspersed repetitive sequences (COBRA-IRS). DNA from neutrophils and peripheral blood mononuclear cells (PBMCs) of BD patients with ocular involvement that were in active or inactive states and healthy controls were used to analyze LINE-1 and Alu methylation levels. For Alu sequences, significant differences were observed in the frequency of uCuC alleles between PBMCs of patients and controls (p = 0.03), and between inactive patients and controls (p = 0.03). For neutrophils, the frequency of uCuC was significantly higher between patients and controls (p = 0.006) and between inactive patients and controls (p = 0.002). The partial methylation (uCmC + mCuC) frequencies of Alu between inactive patients and control samples also differed (p = 0.02). No statistically significant differences for LINE-1 were detected. Thus, changes in the methylation level of IRS elements might contribute to the pathogenesis of BD. The role of Alu transcripts in BD should be investigated further.

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Section: Introductionmentioning

confidence: 99%

Methylation Status of Alu and LINE-1 Interspersed Repetitive Sequences in Behcet’s Disease Patients

Yüksel

Kucukazman²,

Karataş³

et al. 2016

BioMed Research International

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“…Additionally, prominent tissue infiltration by TNF‐α positive cells occurs, as noted in the mucocutaneous ulcers of Behçet disease. Raised secretion of pro‐inflammatory cytokines occurs following inflammatory stimulus in inactive disease . Infliximab, a monoclonal antibody directed against TNF‐α, is consequently a good therapeutic candidate in the treatment of Behçet disease.…”

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confidence: 99%

Use of infliximab and other biologics in Behçet disease

Fernando

Herkes

2014

Internal Medicine Journal

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Behçet disease is a multisystem vasculitis characterised by recurrent oral ulceration in conjunction with other manifestations. Neurological involvement or neuro-Behçet disease is not common, but typically affects young men at its onset between the ages of 20 and 40 with significant long-term morbidity and mortality. There is substantial case literature to support the use of tumour necrosis factor antagonists, notably infliximab, in the treatment of neuro-Behçet disease.

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