Genetics of Behçet's disease

Morton, Laura T.; Situnayake, Deva; Wallace, Graham R.

doi:10.1097/bor.0000000000000234

Cited by 43 publications

(31 citation statements)

References 30 publications

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“…microRNA-155 (miR-155) is one of the most important miRNAs and plays an important role in various biological processes, including immunity [2,3],inflammation [4,5], viral infections [6], cancer [7,8] and cardiovascular disease [9,10]. The homeostasis of inflammation and inflammatory cells is closely related to miR-155 expression and plays a critical role in T cell and B cell development [11,12].…”

Section: Introductionmentioning

confidence: 99%

A comparative study of the characterization of miR-155 in knockout mice

Zhang¹,

Cui²,

Li³

et al. 2017

PLoS ONE

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miR-155 is one of the most important miRNAs and plays a very important role in numerous biological processes. However, few studies have characterized this miRNA in mice under normal physiological conditions. We aimed to characterize miR-155 in vivo by using a comparative analysis. In our study, we compared miR-155 knockout (KO) mice with C57BL/6 wild type (WT) mice in order to characterize miR-155 in mice under normal physiological conditions using many evaluation methods, including a reproductive performance analysis, growth curve, ultrasonic estimation, haematological examination, and histopathological analysis. These analyses showed no significant differences between groups in the main evaluation indices. The growth and development were nearly normal for all mice and did not differ between the control and model groups. Using a comparative analysis and a summary of related studies published in recent years, we found that miR-155 was not essential for normal physiological processes in 8-week-old mice. miR-155 deficiency did not affect the development and growth of naturally ageing mice during the 42 days after birth. Thus, studying the complex biological functions of miR-155 requires the further use of KO mouse models.

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Section: Introductionmentioning

confidence: 99%

A comparative study of the characterization of miR-155 in knockout mice

Zhang¹,

Cui²,

Li³

et al. 2017

PLoS ONE

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“…Its aetiology is unknown but likely involves interplay between genetic and environmental factors [1]. BD has a very heterogeneous and unpredictable phenotype with the potential to involve the cardiovascular, renal, gastrointestinal, pulmonary, vascular, musculoskeletal, urological and central nervous systems to varying degrees [2–4].…”

Section: Introductionmentioning

confidence: 99%

Birmingham Behçet’s service: classification of disease and application of the 2014 International Criteria for Behçet’s Disease (ICBD) to a UK cohort

Blake

Pickup

Carruthers

et al. 2017

BMC Musculoskelet Disord

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BackgroundThis study reports on the analysis of the application and diagnostic predictability of the revised 2014 ICBD criteria in an unselected cohort of UK patients, and the ensuing organ associations and patterns of disease.MethodsA retrospective cohort study was conducted using a database of electronic medical records. Three categories were recognised: clinically defined BD, incomplete BD and rejected diagnoses of BD. We applied the ISG 1990 and ICBD 2014 classification criteria to these subgroups to validate diagnostic accuracy against the multidisciplinary assessment.ResultsBetween 2012 and 2015, 281 patients underwent initial assessment at an urban tertiary care centre: 190 patients with a confirmed diagnosis of BD, 7 with an incomplete diagnosis, and 84 with a rejected diagnosis. ICBD 2014 demonstrated an estimated sensitivity of 97.89% (95% CI: 94.70 to 99.42) and positive likelihood ratio of 1.21 (1.10 to 1.28). The strongest independent predictors were: Central nervous lesions (OR = 10.57, 95% CI: 1.34 to 83.30); Genital ulceration (OR = 9.05, 95% CI: 3.35 to 24.47); Erythema nodosum (OR = 6.59, 95% CI: 2.35 to 18.51); Retinal vasculitis (OR = 6.25, 95% CI: 1.47 to 26.60); Anterior uveitis (OR = 6.16, 95% CI: 2.37 to 16.02); Posterior uveitis (OR = 4.82, 95% CI: 1.25 to 18.59).ConclusionsThe ICBD 2014 criteria were more sensitive at picking up cases than ISG 1990 using the multidisciplinary assessment as the gold standard. ICBD may over-diagnose BD in a UK population. Patients who have an incomplete form of BD represent a distinct group that should not be given an early diagnostic label. Behçet’s disease is a complex disease that is best diagnosed by multidisciplinary clinical assessment. Patients in the UK differ in their clinical presentation and genetic susceptibility from the original descriptions. This study also highlights an incomplete group of Behçet’s patients that are less well defined by their clinical presentation.

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“…Multiple studies demonstrated that inflammatory mediators are highly expressed in patients with BD compared to healthy controls [12] , mainly represented by Th1 and Th17 cells cytokines. In the same way, genetic polymorphisms of inflammatory mediators are associated with disease susceptibility and evolution [13] .…”

Section: Introductionmentioning

confidence: 99%

The anti-Inflammatory activity of Interleukin-37 in Behçet’s disease

Hamzaoui

2016

Inflamm Cell Signal

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Behçet's disease (BD), a systemic vasculitis disorder is associated with the Silk Road. Oral aphtous and genital ulcers, cutaneous pseudo folliculitis and uveitis are the most common manifestations. These manifestations are frequently associated with neurological symptoms, pulmonary involvement and arthritis. The etiology remains uncertain and the most fashionable hypothesis is immunological. BD disease is thought to be caused by pathogenic helper T (Th) cells. Th1, Th2, Th17 and Treg cells have been implicated in its pathogenesis. Recently spotlight has been drawn to novel cytokine of the IL-1 family: interleukin-37 (IL-37). Since its discovery, IL-37 has been studied extensively in immunological field. It has been established that IL-37 inhibits innate and adaptive immunity through suuppression of pro-inflammatory molecules. This review will discuss the role of IL-37 in BD.

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Genetics of Behçet's disease

Abstract: Genetic and epigenetic changes affecting cells and molecules involved in Behçet's disease offer new pathways for research, including cytoskeletal protein function, that will provide new targets for therapy, and potentially address the ethnic differences seen in validation of gene studies.

Cited by 43 publications

References 30 publications

A comparative study of the characterization of miR-155 in knockout mice

A comparative study of the characterization of miR-155 in knockout mice

Birmingham Behçet’s service: classification of disease and application of the 2014 International Criteria for Behçet’s Disease (ICBD) to a UK cohort

The anti-Inflammatory activity of Interleukin-37 in Behçet’s disease

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