Genetics of Alzheimer's Disease

Genetics of Alzheimer Disease

“…Executive dysfunction such as poor judgment, behavior disturbances, and changes in mood all may occur in AD. 2 Symptoms span the course of several years to a decade, and mortality is frequently related to deconditioning. Management is mostly supportive with modest functional improvement in some individuals by using an acetylcholinesterase inhibitor or N-Methyl-D-aspartate antagonist.…”

“…5 Mutations of these 3 genes make up approximately 7 of 10 cases of early-onset familial Alzheimer disease; PSEN1 is the most common and PSEN2 is the rarest ( Table). 2,5 In patients with late-onset Alzheimer disease, there is a greater risk of AD with the presence of the 4 allele of the apolipoprotein E gene, whereas other alleles such as 2 have a lower risk. Other causes such as trisomy 21 may lead to AD due to an identifiable genetic etiology.…”

Editorial: Methods and applications in Alzheimer's disease and related dementias

“…Age is the strongest risk factor for AD, however, a small fraction of patients develop early-onset AD (EOAD) in their 40s or 50s (Bekris et al, 2010). Among the genes associated with EOAD, APP which is located on chromosome 21, encodes the amyloid-beta precursor protein.…”

Alzheimer’s disease: Risk factors and therapeutic targets

“…They are also crucial for the maintenance of neurons by removing unwanted materials [20,21]. Three types of apoԐs (apoԐ 2 , apoԐ 3 , and apoԐ 4 ) exist in equilibrium but apoԐ 4 was found to bear the pathogenic structure [22,23]. It was also found less effective to remove the toxins and repair the problematic neurons [24].…”

“…Noticeably, women are more susceptible than men [2]. The majority of AD occurred in the elderly people (above 65 age), and the risk increased with increasing age but in rare cases it also appeared during one's 40s [3]. It takes several years (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) to progress and badly affect the patients.…”