Genetics, genomics and mechanisms responsible for high levels of pyrethroid resistance in Musca domestica

Freeman, Jamie C.; Scott, Jeffrey G.

doi:10.1016/j.pestbp.2023.105752

Cited by 2 publications

(2 citation statements)

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“…Overexpression of P450 genes can occur because of insertions of cis- or trans-acting transposable elements in the promoter region [ 66 ]. In addition, P450 gene duplication may be a factor in protein overexpression [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

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Genome-Wide Exploration of Long Non-Coding RNAs of Helicoverpa armigera in Response to Pyrethroid Insecticide Resistance

Rahman,

Omoto,

Kim

2024

Insects

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Genome-wide long non-coding RNAs (lncRNAs) in low, moderate, and high pyrethroid insecticide-resistant and -susceptible strains of Helicoverpa armigera were identified in this study. Using 45 illumina-based RNA-sequencing datasets, 8394 lncRNAs were identified. In addition, a sublethal dose of deltamethrin was administered to a Korean-resistant strain (Kor-T). The average length of lncRNAs was approximately 531 bp, and the expression ratio of lncRNAs was 28% of the total RNA. The identified lncRNAs were divided into six categories—intronic, intergenic, sense, antisense, cis-RNA, and trans-RNA—based on their location and mechanism of action. Intergenic and intronic lncRNA transcripts were the most abundant (38% and 33%, respectively). Further, 828 detoxification-related lncRNAs were selected using the Gene Ontology analysis. The cytochrome P450-related lncRNA expression levels were significantly higher in susceptible strains than in resistant strains. In contrast, cuticle protein-related lncRNA expression levels were significantly higher in all resistant strains than in susceptible strains. Our findings suggest that certain lncRNAs contribute to the downregulation of insecticide resistance-related P450 genes in susceptible strains, whereas other lncRNAs may be involved in the overexpression of cuticle protein genes, potentially affecting the pyrethroid resistance mechanism.

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Section: Discussionmentioning

confidence: 99%

“…Metabolic enzymes may be involved in the detoxification of insect resistance mechanisms [ 50 , 51 ]. Detoxification genes were searched from the annotated sequences of protein databases and protein BLAST and compared to those of H. armigera (Harm_GR_Male_#8, GCA_002156985.1).…”

Section: Methodsmentioning

confidence: 99%