Genetics, energetics and allostery during a billion years of hydrophobic protein core evolution
Albert Escobedo,
Gesa Voigt,
Andre J Faure
et al.
Abstract:Protein folding is driven by the burial of hydrophobic amino acids in a tightly-packed core that excludes water. The genetics, biophysics and evolution of hydrophobic cores are not well understood, in part because of a lack of systematic experimental data on sequence combinations that do - and do not - constitute stable and functional cores. Here we randomize protein hydrophobic cores and evaluate their stability and function at scale. The data show that vast numbers of amino acid combinations can constitute s… Show more
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