Genetics and genomics etiology of nonsyndromic orofacial clefts

Adeyemo, WL; Butali, Azeez

doi:10.1002/mgg3.272

Cited by 15 publications

(12 citation statements)

References 47 publications

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“…The nonsyndromic cases represent about 70% of all OFC cases (Beaty et al 2016;Adeyemo and Butali 2017). Genes such as PAX7, GRHL3, FGF, FGFR2, IRF6, BMP4, TGFA, TGFB1, and VAX1 are reported as causal genes for OFC (Beaty et al 2016;Li et al 2016;Adeyemo and Butali 2017). Of these genes, PAX7, BMP4, FGF2, and FGF5 are also related to muscle development.…”

Section: Genetic Factors In Orofacial Clefts and Muscle Developmentmentioning

confidence: 99%

Orofacial Muscles: Embryonic Development and Regeneration after Injury

et al. 2019

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Orofacial congenital defects such as cleft lip and/or palate are associated with impaired muscle regeneration and fibrosis after surgery. Also, other orofacial reconstructions or trauma may end up in defective muscle regeneration and fibrosis. The aim of this review is to discuss current knowledge on the development and regeneration of orofacial muscles in comparison to trunk and limb muscles. The orofacial muscles include the tongue muscles and the branchiomeric muscles in the lower face. Their main functions are chewing, swallowing, and speech. All orofacial muscles originate from the mesoderm of the pharyngeal arches under the control of cranial neural crest cells. Research in vertebrate models indicates that the molecular regulation of orofacial muscle development is different from that of trunk and limb muscles. In addition, the regenerative ability of orofacial muscles is lower, and they develop more fibrosis than other skeletal muscles. Therefore, specific approaches need to be developed to stimulate orofacial muscle regeneration. Regeneration may be stimulated by growth factors such fibroblast growth factors and hepatocyte growth factor, while fibrosis may be reduced by targeting the transforming growth factor β1 (TGFβ1)/myofibroblast axis. New approaches that combine these 2 aspects will improve the surgical treatment of orofacial muscle defects.

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Section: Genetic Factors In Orofacial Clefts and Muscle Developmentmentioning

confidence: 99%

Orofacial Muscles: Embryonic Development and Regeneration after Injury

et al. 2019

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“…The Aims and Scope of MGGM were and are broad, to encompass a wide range of topics including basic and translational science, technological advances, human and medical genetics, animal models of human disease, pharmacogenomics and translational medicine (Muenke, ). From the first Editorial to the Invited Commentaries in each issue, various aspects of genomic medicine have been illustrated: integration of genomic information into the delivery of health care (De Castro & Turner, ; Eng, ; Francke, ; Slavotinek, ; Solomon, ; Williams, ), educational opportunities (Hart & Hart, ; Korf, ; McCarthy, ; Muenke, ), genomic counseling (Middleton, Hall, & Patch, ; Ormond, ); diverse populations (Adeyemo & Rotimi, ), ethical considerations (Wilfond & Goddard, ; one of the 10 most highly cited articles in MGGM , see below), comparative genomics (Mullikin, ), and many more including specific groups of diseases: newborn screening (Levy, ); substance use disorders (Rutter & Volkow, ); hearing loss (Pandya, ); orofacial clefting (Adeyemo & Butali, ), and stuttering (Frierio‐Domingues & Drayna, ). Some of my personal (M.M.)…”

Section: Genetics and Genomic Medicine Around The Worldmentioning

confidence: 99%

Looking back and looking forward

Muenke

Hart

2018

Molec Gen & Gen Med

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“…Two of the most well characterized epigenetic alterations are histone modification and DNA methylation [ 153 ]. Beyond the genome, the complete set of epigenetic modifications to the cellular DNA or histones (epigenome) are known to play an important role in the etiology of diseases [ 154 ]. The epigenome plays a pivotal role in the regulation of chromatin activity and therefore affect DNA repair and gene expression [ 152 ].…”

Section: Main Textmentioning

confidence: 99%

Omics-based molecular techniques in oral pathology centred cancer: prospect and challenges in Africa

et al. 2017

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BackgroundThe completion of the human genome project and the accomplished milestones in the human proteome project; as well as the progress made so far in computational bioinformatics and “big data” processing have contributed immensely to individualized/personalized medicine in the developed world.Main bodyAt the dawn of precision medicine, various omics-based therapies and bioengineering can now be applied accurately for the diagnosis, prognosis, treatment, and risk stratification of cancer in a manner that was hitherto not thought possible. The widespread introduction of genomics and other omics-based approaches into the postgraduate training curriculum of diverse medical and dental specialties, including pathology has improved the proficiency of practitioners in the use of novel molecular signatures in patient management. In addition, intricate details about disease disparity among different human populations are beginning to emerge. This would facilitate the use of tailor-made novel theranostic methods based on emerging molecular evidences.ConclusionIn this review, we examined the challenges and prospects of using currently available omics-based technologies vis-à-vis oral pathology as well as prompt cancer diagnosis and treatment in a resource limited setting.

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Genetics and genomics etiology of nonsyndromic orofacial clefts

Cited by 15 publications

References 47 publications

Orofacial Muscles: Embryonic Development and Regeneration after Injury

Orofacial Muscles: Embryonic Development and Regeneration after Injury

Looking back and looking forward

Omics-based molecular techniques in oral pathology centred cancer: prospect and challenges in Africa

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