Genetics and cytogenetics of Waldenstrom's macroglobulinemia

Schop, Roelandt F.J.; Fonseca, Rafaël

doi:10.1053/sonc.2003.50075

Cited by 27 publications

(13 citation statements)

References 34 publications

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“…However, as a result of chromosomal translocations between these genes and the IGH locus, these genes exhibit a characteristic “spiked” pattern in specific subsets of tumors. Although WM has been shown to lack translocations involving the IGH locus (24), we nevertheless applied to WM samples a method used to identify spiked gene expression in MM. This strategy was employed to identify genes that may not be uniformly overexpressed across the entire group but might nevertheless be highly overexpressed in subsets of patients and therefore may point to subtypes of disease.…”

Section: Resultsmentioning

confidence: 99%

Gene Expression Profiling Reveals Aberrant T-cell Marker Expression on Tumor Cells of Waldenström's Macroglobulinemia

Hao

Barlogie

Tricot

et al. 2019

Clinical Cancer Research

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Purpose: That the malignant clone of Waldenström’s macroglobulinemia (WM) demonstrates significant intraclonal heterogeneity with respect to plasmacytoid differentiation indicates the mechanistic complexity of tumorigenesis and progression. Identification of WM genes by comparing different stages of B cells may provide novel druggable targets. Experimental Design: The gene expression signatures of CD19+ B cells (BC) and CD138+ plasma cells (PC) from 19 patients with WM were compared to those of BC from peripheral blood and tonsil and to those of PC from the marrow of healthy (N-PC) and multiple myeloma donors (MM-PC), as well as tonsil (T-PC). The flow cytometry and immunofluorescence were used to examine T-cell marker expression on WM tumor cells. Results: Consistent with defective differentiation, both BC and PC from WM cases expressed abnormal differentiation markers. Sets of 55 and 46 genes were differentially expressed in WM-BC and WM-PC, respectively; and 40 genes uniquely dysregulated in WM samples were identified. Dysregulated genes included cytokines, growth factor receptors, and oncogenes not previously implicated in WM or other plasma cell dyscrasias. Interestingly, strong upregulation of both IL6 and IL6R was confirmed. Supervised cluster analysis of PC revealed that marrow-derived WM-PC was either MM-PC-like or T-PC-like, but not N-PC-like. The aberrant expression of T cell markers was confirmed at the protein level in WM-BC. Conclusions: We showed that comparative microarray profiles allowed to gain more comprehensive insights into the biology of WM. The data presented here have implications for the development of novel therapies, such as targeting aberrant T-cell markers in WM.

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Section: Resultsmentioning

confidence: 99%

Gene Expression Profiling Reveals Aberrant T-cell Marker Expression on Tumor Cells of Waldenström's Macroglobulinemia

Hao

Barlogie

Tricot

et al. 2019

Clinical Cancer Research

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“…WM plasma cells express CD19), which is helpful in the differential diagnosis (Morice et al , ). Cytogenetic analysis is not required for the routine diagnostic assessment of WM patients as it is difficult to obtain tumour metaphases in vitro (Schop & Fonseca, ). There are no disease‐defining cytogenetic abnormalities.…”

Section: Methodsmentioning

confidence: 99%

“…There are no disease‐defining cytogenetic abnormalities. Deletion 6q and trisomy 4 are frequent cytogenetic abnormalities described in WM (Schop & Fonseca, ; Ocio et al , ; Braggio & Fonseca, ; Nguyen‐Khac et al , ). Conventional cytogenetic or fluorescence in situ hybridization studies may be useful, however, in the differential diagnosis.…”

Section: Methodsmentioning

confidence: 99%

Recommendations for the diagnosis and initial evaluation of patients with Waldenström Macroglobulinaemia: A Task Force from the 8th International Workshop on Waldenström Macroglobulinaemia

et al. 2016

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The diagnosis of Waldenström macroglobulinemia (WM) can be challenging given the variety of signs and symptoms patients can present. Furthermore, once the diagnosis of WM is established, the initial evaluation should be thorough as well as appropriately directed. During the 8th International Workshop for WM in London, United Kingdom, a multi-institutional task force was formed to develop consensus recommendations for the diagnosis and initial evaluation of patients with WM. In this document, we present the results of the deliberations taken place to address these issues. We provide recommendations for history taking and physical examination, laboratory studies, bone marrow aspiration and biopsy analysis and imaging studies. We also provide guidance on the initial evaluation of special situations such as anemia, hyperviscosity, neuropathy, Bing-Neel syndrome and amyloidosis. We hope these recommendations serve as a practical guidance to clinicians taking care of patients with a suspected or an established diagnosis of WM.

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“…Unlike other B-cell malignancies, chromosomal translocations involving the IgH locus are relatively uncommon in both CLL and WM. 24,25 These IgH translocations are thought to occur either during immunoglobulin VDJ recombination in maturing B cells or during immunoglobulin somatic hypermutation and isotype switching in mature B cells within the germinal center (GC). 26 They are therefore common in B-cell lymphomas, which are usually derived from GC B cells.…”

Section: Discussionmentioning

confidence: 99%

Gene-expression profiling of Waldenström macroglobulinemia reveals a phenotype more similar to chronic lymphocytic leukemia than multiple myeloma

Chng

Schop

Price-Troska

et al. 2006

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Genetics and cytogenetics of Waldenstrom's macroglobulinemia

Cited by 27 publications

References 34 publications

Gene Expression Profiling Reveals Aberrant T-cell Marker Expression on Tumor Cells of Waldenström's Macroglobulinemia

Gene Expression Profiling Reveals Aberrant T-cell Marker Expression on Tumor Cells of Waldenström's Macroglobulinemia

Recommendations for the diagnosis and initial evaluation of patients with Waldenström Macroglobulinaemia: A Task Force from the 8th International Workshop on Waldenström Macroglobulinaemia

Gene-expression profiling of Waldenström macroglobulinemia reveals a phenotype more similar to chronic lymphocytic leukemia than multiple myeloma

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