Genetically modified cell spheroids for tissue engineering and regenerative medicine

Sonocatalytic cancer therapy: theories, advanced catalysts and system design

“…The implosive collapse of cavitation bubbles in inertial cavitation generates extremely high temperatures (up to 10 000 K) and enormous pressures (81 MPa) at the cavitation core. 27 Such extreme heat and pressure may decompose H 2 O into free radicals ( • OH), which can further react with endogenous substrates to produce other ROS. Owing to the localized energy release and high cooling rates, collateral damage to adjacent tissues is minimal.…”

Improvement of the effectiveness of sonodynamic therapy: by optimizing components and combination with other treatments

“…86 Unfortunately, it is obvious that inorganic sonosensitizers need to focus more attention on potential biosafety. [87][88][89][90] The combination of sonosensitizers and nanoplatforms can move beyond some of the inherent drawbacks of sonosensitizers and achieve higher tumor inhibition rates and improved ROS conversion rates.…”

Tumor microenvironment-regulated drug delivery system combined with sonodynamic therapy for the synergistic treatment of breast cancer

“…[6][7][8] However, conventional sonosensitizers suffer from limitations including inferior biocompatibility, rapid degradation, and low ROS production, leading to low SDT efficiency. 9,10 To address these issues, researchers have explored the use of nanocarriers for delivering sonosensitizers to enhance their therapeutic efficacy. Owing to their biological characteristics, for example, small particle sizes and large surface-to-body ratios, nanomaterials can efficiently carry small drugs to tumor areas.…”