Genetically induced retinal degeneration leads to changes in metabotropic glutamate receptor expression

Armata, Ioanna A.; Giompres, Panagiotis; Smith, Adam L.; Stasi, Kalliopi; Kouvelas, Elias D.; Mitsacos, Ada

doi:10.1016/j.neulet.2005.09.038

Cited by 5 publications

(2 citation statements)

References 32 publications

(43 reference statements)

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“…We therefore hypothesize that the ON bipolar transduction mechanism translocates to dendritic shafts and/or ON bipolar cell bodies so as to preserve cells’ ability to respond to glutamatergic stimulation (e.g., Nomura et al, 1994). An upregulation and redistribution of the GRM6 protein to ON bipolar somata have been previously associated with the progressive loss of rods in the Royal College of Surgeons (RCS) rat retina (Nomura et al, 1994; Armata et al, 2006) whereas a decrease in mGluR6 immunoreactivity was reported for Pde6b rd10 retinas (Gargini et al, 2007). …”

Section: Discussionmentioning

confidence: 98%

Plasticity of TRPM1 expression and localization in the wild type and degenerating mouse retina

Križaj

Huang

Furukawa³

et al. 2010

Vision Research

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The light response in retinal ON bipolar cells is associated with disinhibition of current flow through cation channels recently identified as type 1 members of the melastatin transient receptor potential (TRPM) family. We determined the developmental expression of Trpm1 in the wild type C57BL/6, DBA/2J, DBA2J-Gpnmb mouse retinas and in Pde6brd1 retinas characterized by degeneration of rod photoreceptors. Trpm1 mRNA in wild type retinas was low at birth but exhibited progressive increases in abundance up to early adulthood at postnatal day 21 (P21). Retinal Trpm1 mRNA content did not decrease following loss of photoreceptors. At P21, TRPM1-immunopositive perikarya migrated into the outer nuclear layer. The TRPM1 protein was trafficked to discrete postsynaptic puncta in wild type retinas whereas in adult Pde6brd1 mouse retinas, TRPM1 translocated to bipolar perikarya and bar-like structures in the distal inner nuclear layer. These findings show that expression and localization of the TRPM1 in the mouse retina is plastic, modulated by use-dependence and availability of sustained excitatory input.

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Section: Discussionmentioning

confidence: 98%

Plasticity of TRPM1 expression and localization in the wild type and degenerating mouse retina

Križaj

Huang

Furukawa³

et al. 2010

Vision Research

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“…No studies to date have implicated GRM6 with schizophrenia or other psychiatric disorders, with much of the research focusing on this gene confined to studies of the retina [Armata et al, 2006].…”

Section: Group III Mglursmentioning

confidence: 99%

Metabotropic Glutamate Receptor Genes as Candidates for Pharmacogenetic Studies of Current and Future Antipsychotic Agents in Schizophrenia

Bishop

Ellingrod

2007

CPG

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Recent research has linked the polymorphic metabotropic glutamate receptors to the pathogenesis of schizophrenia contributing to the development of the "glutamate hypothesis". These receptors regulate glutamate through NMDA inotropic receptors. At the neurotransmitter level, antipsychotics developed to treat schizophrenia have been found to significantly increase serum glutamate levels and potentially affect the expression of various metabotropic glutamate receptors (mGluRs). Additionally, type-3 metabotropic glutamate receptor gene (GRM3) polymorphisms have been associated with schizophrenia as well as being linked to reductions in prefrontal cortex N-acetylaspartate concentrations. Thus, glutamate has become an increasingly important area of interest for therapeutic intervention in schizophrenia and pharmaceutical companies are rapidly focusing on the development of agents that directly modulate this neurotransmitter; however the reality is that the clinical use of such drugs is still years away. Taken together, investigations of how genetic variability in genes coding for mGluRs relate to treatment outcomes are becoming increasingly important. The goal of this review is to discuss the genetics, pharmacology, and pharmacogenetics of the metabotropic glutamate receptors focusing on receptor subtypes with the most evidence for involvement with current and/or future antipsychotic activity.

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Neurotransmitter Stimulation for Retinal Prosthesis: The Artificial Synapse Chip

Iezzi

Finlayson

2011

Visual Prosthetics

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Genetically induced retinal degeneration leads to changes in metabotropic glutamate receptor expression

Cited by 5 publications

References 32 publications

Plasticity of TRPM1 expression and localization in the wild type and degenerating mouse retina

Plasticity of TRPM1 expression and localization in the wild type and degenerating mouse retina

Metabotropic Glutamate Receptor Genes as Candidates for Pharmacogenetic Studies of Current and Future Antipsychotic Agents in Schizophrenia

Neurotransmitter Stimulation for Retinal Prosthesis: The Artificial Synapse Chip

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