Genetically diverse pig models for neonatal cholesterol nutrition: A review

Mersmann, Harry J.

doi:10.1016/0271-5317(96)00048-6

Cited by 8 publications

(3 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The heritability of serum CHOL in swine in the current study was medium-to-large and comparable with that in humans (Feitosa et al, 2005). This result agreed with estimates previously reported in other pig populations (Rothschild and Chapman, 1976;Pond et al, 1986;Pond and Mersmann, 1996) and also with swine selection experiments with effective changes on serum CHOL (Pond et al, 1993;Young et al, 1993). Conversely, heritabilities for TG concentrations at both ages were also large but less than those reported by Pond et al (1986).…”

Section: Heritabilities For Serum Lipid and Meat Composition Traitssupporting

confidence: 91%

Bayes factor analyses of heritability for serum and muscle lipid traits in Duroc pigs1

Casellas¹,

Noguera²,

Reixach³

et al. 2010

Journal of Animal Science

View full text Add to dashboard Cite

Concern about pork quality has increased during last decades. Given the influence of fat content and composition on sensorial, nutritional, and technological variables of pork meat, an accurate knowledge about genetic control of pig lipid metabolism is required. This study focused on providing a broad characterization for serum and meat lipid trait heritability estimates in pigs. Analyses were performed on a population of 370 Duroc barrows and measured the additive polygenic background for the serum concentrations of cholesterol, triglyceride, and low- and high-density lipoproteins at 45 and 190 d of age (at slaughter), as well as intramuscular fat, cholesterol content, and C:12 to C:22 fatty acid content in longissimus thoracis et lumborum and gluteus medius muscles at slaughter. These traits were analyzed under Bayesian univariate animal linear models, and the statistical relevance of heritability estimates was evaluated through Bayes factor (BF); the model with polygenic additive effects was favored when BF >1. All serum lipid traits showed relevant genetic determinism, but the BF reached greater values at 190 d of age. Serum lipid traits displayed moderate modal estimates for heritability that ranged from 0.18 to 0.30. On the other hand, the genetic determinism for meat quality traits showed a heterogeneous behavior with large and less-than-1 BF. In general, longissimus thoracis et lumborum and gluteus medius muscles showed a similar pattern, with strong evidence of polygenic additive effects for intramuscular fat and palmitic, stearic, and cis-vaccenic fatty acids content, whereas oleic and muscle cholesterol content showed moderate to weak BF with moderate heritabilities. Similarly, results regarding linoleic, arachidonic, n-3, and n-6 fatty acids suggested a moderate genetic determinism, but only in gluteus medius muscle. For the remaining traits (myristic and palmitoleic fatty acids in both muscles, along with linoleic, arachidonic, n-3, and n-6 fatty acids in the longissimus thoracis et lumborum muscle), no statistical evidence for genetic control was observed in this study. As a whole, these results confirm the complexity of lipid metabolism in pigs.

show abstract

Section: Heritabilities For Serum Lipid and Meat Composition Traitssupporting

confidence: 91%

Bayes factor analyses of heritability for serum and muscle lipid traits in Duroc pigs1

Casellas¹,

Noguera²,

Reixach³

et al. 2010

Journal of Animal Science

View full text Add to dashboard Cite

show abstract

“…In other studies, however, the addition of 0.5% cholesterol to the diet of genetically bred pigs during days 1 to 28 of age led to elevated cerebrum cholesterol levels at 6 months of age (152). In pigs bred to have low plasma cholesterol levels, the addition of cholesterol also increased some aspects of exploratory behavior at day 28 (reviewed in reference 153). Also, in DBA/2 mice (which have impaired learning and memory), subcutaneous implantation of cholesterol pellets improved learning performance (154).…”

Section: Cholesterolmentioning

confidence: 99%

Nutritional Implications of Replacing Bovine Milk Fat With Vegetable Oil in Infant Formulas

Berger,

Fleith,

Crozier

2000

J. pediatr. gastroenterol. nutr.

View full text Add to dashboard Cite

“…In this paper, we describe the use of pig's bile as a convenient, rapid, and reliable source of natural micelles for cholesterol solubilization and cholesterol absorption into the Caco-2 cell system. Pig's bile was chosen because of its availability and because the diet, physiology, and bile of pigs closely model those of humans (10). Catechin gallates (9,11,12) and bovine milk peptides from tryptic digestion of β-lactoglobulin ( 13) have been shown to inhibit cholesterol solubilization and uptake into micelles and Caco-2 cells, respectively, and were used as reference inhibitory compounds.…”

Section: Introductionmentioning

confidence: 99%

Naturally Derived Micelles for Rapid in Vitro Screening of Potential Cholesterol-Lowering Bioactives

Kirana

Rogers

Bennett

et al. 2005

J. Agric. Food Chem.

View full text Add to dashboard Cite

A high plasma cholesterol level, especially low-density lipoprotein cholesterol, indicates increased risk of cardiovascular diseases. Plasma cholesterol levels are influenced by diet and cholesterol biosynthesis, uptake, and secretion. Cholesterol uptake involves solubilization into complex phospholipid spherical bodies termed micelles that facilitate the transport of lipids through the gut brush border membrane into enterocytes. In vitro assays reported to date to determine potential cholesterol-lowering effects of various compounds require artificial micelle preparations that are elaborate and time-consuming to prepare. The aims of this study were to compare the efficacy of artificially prepared micelles with naturally derived micelles from pig's bile and to test their ability to assess potential inhibitors of cholesterol uptake. The suitability of pig's bile-derived micelles was tested both at the level of the micelle and at cellular uptake using cultured Caco-2 cells. Known cholesterol uptake inhibitors at the micelle (green tea catechins) and at the Caco-2 cell (beta-lactoglobulin-derived peptide, IIAEK) were used as reference inhibitory compounds. It was concluded that pig's bile was a rapid, reproducible, convenient, and cost-effective source of micelles for cholesterol micelle solubility and cellular uptake assay systems and is suitable for screening purposes focused on identifying potential cholesterol-lowering agents.

show abstract

Genetically diverse pig models for neonatal cholesterol nutrition: A review

Cited by 8 publications

References 39 publications

Bayes factor analyses of heritability for serum and muscle lipid traits in Duroc pigs1

Bayes factor analyses of heritability for serum and muscle lipid traits in Duroc pigs1

Nutritional Implications of Replacing Bovine Milk Fat With Vegetable Oil in Infant Formulas

Naturally Derived Micelles for Rapid in Vitro Screening of Potential Cholesterol-Lowering Bioactives

Contact Info

Product

Resources

About