2009
DOI: 10.1111/j.1601-183x.2009.00522.x
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Genetically correlated effects of selective breeding for high and low methamphetamine consumption

Abstract: Improved prevention and treatment of drug addiction will require deeper understanding of genetic factors contributing to susceptibility to excessive drug use. Intravenous operant self-administration methods have greatly advanced understanding of behavioral traits related to addiction. However, these methods are not suitable for large-scale genetic experiments in mice. Selective breeding of mice can aggregate 'addiction alleles' in a model that has the potential to identify coordinated effects of multiple genes… Show more

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Cited by 73 publications
(284 citation statements)
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References 50 publications
(84 reference statements)
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“…Transgenic mice homozygous or heterozygous for a functional Taar1 allele avoid MA consumption and are sensitive to MA-induced CTA and hypothermia. Similarly, MALDR mice, which are either homozygous or heterozygous for a functional Taar1 allele, avoid MA consumption and are sensitive to aversive effects of MA (Wheeler et al, 2009;Shabani et al, 2011Shabani et al, , 2012b and MA-induced hypothermia. This outcome is clear in two replicate sets of MADR lines, which strongly supports TAAR1 and Methamphetamine Intake JH Harkness et al common genetic influence on MA consumption and sensitivity to the aversive and hypothermic effects of MA.…”
Section: Discussionmentioning
confidence: 99%
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“…Transgenic mice homozygous or heterozygous for a functional Taar1 allele avoid MA consumption and are sensitive to MA-induced CTA and hypothermia. Similarly, MALDR mice, which are either homozygous or heterozygous for a functional Taar1 allele, avoid MA consumption and are sensitive to aversive effects of MA (Wheeler et al, 2009;Shabani et al, 2011Shabani et al, , 2012b and MA-induced hypothermia. This outcome is clear in two replicate sets of MADR lines, which strongly supports TAAR1 and Methamphetamine Intake JH Harkness et al common genetic influence on MA consumption and sensitivity to the aversive and hypothermic effects of MA.…”
Section: Discussionmentioning
confidence: 99%
“…Procedures were identical to those used during selection of the MADR lines (Shabani et al, 2011;Wheeler et al, 2009). MADR or Taar1 transgenic mice were isolate-housed and habituated for 48 h to drinking from two water-filled drinking tubes.…”
Section: General Proceduresmentioning
confidence: 99%
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