Genética da artrite reumatoide: é necessário um novo impulso em populações latino‐americanas

Abstract

Rheumatoid arthritis (RA) is an autoimmune inflammatory rheumatic disease which affects several organs and tissue, predominantly the synovial joints. Like many other autoimmune diseases, RA is a complex disease, where genetic variants, environmental factors and random events interact to trigger pathological pathways. Genetic implication in RA is evident, and recent advances have expanded our knowledge about the genetic factors that contribute to RA. An exponential increment in the number of genes associated with the disease has been described, mainly through gene wide screen studies (GWAS) involving international consortia with large patient cohorts. However, there are a few studies on Latin American populations. This article describes what is known about the RA genetics, the future that is emerging, and how this will develop a more personalized approach for the treatment of the disease. Latin American RA patients cannot be excluded from this final aim, and a higher collaboration with the international consortia may be needed for a better knowledge of the genetic profile of patients from this origin.

Anti-Arthritic and Anti-Inflammatory Potential of Spondias mangifera Extract Fractions: An In Silico, In Vitro and In Vivo Approach

“…Rheumatoid arthritis (RA) is an autoimmune disorder, which can result in chronic inflammation in the synovial membrane and also cause pain in small and large joints, as well as the destruction of cartilage and bone [ 4 ]. The characteristic features of RA are joint pain, immobility and malformation [ 5 ].…”

Prognostic significance of high-mobility group box protein 1 genetic polymorphisms in rheumatoid arthritis disease outcome

“…Knowing how an individual's genetic make-up regulates disease predisposition and outcome can help us better understand aspects of disease biology and facilitate diagnosis, understand the importance of tailoring treatment to the patient, and, eventually, enable a cure or the opportunity to prevent the disease. Genetic analyses of RA pathogenesis demonstrate considerable heterogeneity among individuals and populations 4 , 5 . Global genome-wide association studies (GWASs) involving large patient cohorts and typically using many hundreds of thousands of single nucleotide polymorphisms (SNPs) have contributed much understanding to RA etiology 6 .…”