Genetic Variations rs11892031 and rs401681 Are Associated with Bladder Cancer Risk in a Chinese Population

Abstract

Genome-wide association studies (GWAS) have identified a number of genetic variants associated with risk of bladder cancer in populations of European descent. Here, we assessed association of two of these variants, rs11892031 (2q37.1 region) and rs401681 (5p15.33 region) in a Chinese case-control study, which included 367 bladder cancer cases and 420 controls. We found that the AC genotype of rs11892031 was associated with remarkably decreased risk of bladder cancer (adjusted odds ratio (OR), 0.27; 95% confidence interval (CI), 0.09-0.81; p = 0.019), compared with the AA genotype of rs11892031; and that CT/CC genotypes of rs401681 were associated with significantly increased risk of bladder cancer (adjusted OR, 1.79; 95% CI, 1.10-2.91; p = 0.02), compared with the TT genotype of rs401681. We further conducted stratification analysis to examine the correlation between single nucleotide polymorphism (SNP) rs11892031/rs401681 and OPEN ACCESS Int. J. Mol. Sci. 2014, 15 19331 tumor grade/stage. Results showed that heterogeneity in ORs of tumor categories was not significant for either rs11892031 or rs401681 (p > 0.05), indicating that the two SNPs seemingly do not associate with tumor grade and stage of bladder cancer in our study population. The present study suggests that the SNPs rs11892031 and rs401681 are associated with bladder cancer risk in a Chinese population. Future analyses will be conducted with more participants recruited in a case-control study.

Association of gastrointestinal gland cancer susceptibility loci with esophageal carcinoma among the Chinese Han population: a case–control study

“…However, a recent study reported that CLPTM1L is a commonly overexpressed anti-apoptotic factor in lung cancer [30,32]. Our study and previous research suggest that one SNP can be associated with two or more cancers; for example, rs401681 is associated with many cancers including pancreatic cancer, lung cancer, bladder cancer, and hepatocellular carcinoma [33][34][35]. Further studies are needed to clarify the genetic mechanism of esophageal carcinogenesis by fine mapping the susceptibility region of the variants.…”

MicroRNA-379-5p plays a tumor-suppressive role in human bladder cancer growth and metastasis by directly targeting MDM2

“…Bladder cancer is the second most common urological malignancy in the US and is by far the most frequently diagnosed urological malignancy in China. Epidemiological data provided by the International Agency for Research on Cancer (IARC) in 2012 reported 55,486 cases and 26,820 deaths of bladder cancer in China (1). A total of 740,000 new cases and 16,000 deaths caused by bladder cancer were recorded in 2015 in the US (2).…”

The Rare Variant rs35356162 in UHRF1BP1 Increases Bladder Cancer Risk in Han Chinese Population

“…Genome-wide association studies (GWAS) have identified 17 independent loci and single nucleotide variants (SNVs) that contribute to bladder cancer susceptibility in European population [(8-14); Table S1]. Many loci have been replicated in additional studies, and additional new loci found to be, associated with bladder cancer risk in Chinese population (15)(16)(17)(18)(19)(20)(21). GWA studies have been successful in identifying common variants involved in complex trait etiology.…”