Genetic variations of interleukin-1 and -6 genes and risk of cervical intraepithelial neoplasia

Grimm, Christoph; Watrowski, Rafał; Baumühlner, Konstantin; Natter, C; Tong, Dan; Wolf, Andrea; Zeillinger, Robert; Leodolter, Sepp; Reinthaller, Alexander; Hefler, Lukas

doi:10.1016/j.ygyno.2011.02.019

Cited by 32 publications

(23 citation statements)

References 44 publications

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“…28 If the aggressiveness and presence of cervical cancer in a young woman is due to a genetic alteration, we would expect that would most likely be seen in regional studies such as the Japanese study compared with the genetically diverse population in the United States. There does appear to be an association of cervical cancer with a large variety of polymorphisms in a wide variety of genes, including genes that regulate immunity and susceptibility, 29 cytokine production, 30,31 angiogenesis, tumor suppressor pathways, 32,33 and signal transducer and activator of transcription pathways. 34 Investigations are ongoing to identify genetic alterations that may make women less likely to clear persistent HPV infections and more susceptible to the development of cervical cancer.…”

Section: Discussionmentioning

confidence: 99%

Cervical Cancer in Women Aged 35 Years and Younger

Pelkofski

Stine

Wages

et al. 2016

Clinical Therapeutics

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Section: Discussionmentioning

confidence: 99%

Cervical Cancer in Women Aged 35 Years and Younger

Pelkofski

Stine

Wages

et al. 2016

Clinical Therapeutics

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“…DNA was amplified with polymerase chain reaction (PCR) and DNA pyrosequencing was performed according to established protocols as described previously [23]. After researching dbSNP , the SNP database from National Center for Biotechnology Information, and PubMed, the five most common and clinically relevant TAP gene polymorphisms (i.e., TAP 1341, TAP 2254, TAP 1135, TAP 1693, and TAP 1993) were chosen for investigation.…”

Section: Methodsmentioning

confidence: 99%

Association of TAP Gene Polymorphisms and Risk of Cervical Intraepithelial Neoplasia

et al. 2013

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Background. Transporter associated with antigen processing (TAP) is responsible for peptide loading onto class I major histocompatibility complex (MHC-I) molecules. TAP seems to facilitate the detection of HPV by MHC-I molecules and contributes to successful eradication of HPV. TAP polymorphisms could have an important impact on the course of HPV infection. Objective. The aim of this study is to evaluate the association between five TAP gene polymorphisms and the risk of CIN. Methods. This case-control study investigated five common TAP polymorphisms in TAP1 (1341 and 2254) and TAP2 (1135, 1693, and 1993) in 616 women with CIN and 206 controls. Associations between gene polymorphisms and risk of CIN were analysed by univariate and multivariable models. The combined effect of the five TAP gene polymorphisms on the risk for CIN was investigated by haplotype analysis. Results. No significant difference in genotype distribution of the five TAP polymorphisms was observed in women with CIN and controls. Haplotype analysis revealed that women with haplotype mut-wt-wt-wt-wt (TAP polymorphisms t1135-t1341-t1693-t1993-t2254) had a significantly lower risk for CIN, compared to women with the haplotype wt-wt-wt-wt-wt (P = 0.006; OR 0.5 [0.35–0.84]). Conclusion. Identification of this haplotype combination could be used to identify women, less susceptible for development of CIN following HPV infection.

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“…The majority of HPV infections are transient and do not lead to genital dysplasia. Genetic factors, cigarette smoking, sexually transmitted diseases and idiopathic as well as iatrogenic immunosuppression are established factors for HPV persistence and subsequent development of CIN . Interleukins (IL) play a key role in cellular immunity and carcinogenesis as they have received particular attention in HPV‐clearance and the pathogenesis of cervical cancer.…”

Section: Introductionmentioning

confidence: 99%