Genetic variations of FACL4 have no obvious influence on cognitive ability in young Chinese children

Zhang, Kejin; Zheng, Zijian; An, Caiyan; Gao, Xiaocai; Zhang, Fuchang

doi:10.1016/j.psychres.2009.11.020

Cited by 1 publication

(2 citation statements)

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Section: Discovery Of Acsl4mentioning

confidence: 99%

“…In 2002, Meloni et al found that ACSL4 was highly expressed in the human adult brain, especially in the cerebellum and hippocampus, and exhibited a distribution similar to that in mice [24]. Subsequent studies have shown that ACSL4 plays an important role in many biological processes, such as cell death, development, inflammation, autophagy, and metabolism [14,[25][26][27][28]. In conclusion, the cloning of ACSL4 is the result of years of effort by multiple researchers and studies involving various fields, including gene sequencing, expression regulation, biological processes, and disease development.…”

Section: Discovery Of Acsl4mentioning

confidence: 99%

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The ACSL4 Network Regulates Cell Death and Autophagy in Diseases

Chen

Kang

Liu

et al. 2023

Biology

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Lipid metabolism, cell death, and autophagy are interconnected processes in cells. Dysregulation of lipid metabolism can lead to cell death, such as via ferroptosis and apoptosis, while lipids also play a crucial role in the regulation of autophagosome formation. An increased autophagic response not only promotes cell survival but also causes cell death depending on the context, especially when selectively degrading antioxidant proteins or organelles that promote ferroptosis. ACSL4 is an enzyme that catalyzes the formation of long-chain acyl-CoA molecules, which are important intermediates in the biosynthesis of various types of lipids. ACSL4 is found in many tissues and is particularly abundant in the brain, liver, and adipose tissue. Dysregulation of ACSL4 is linked to a variety of diseases, including cancer, neurodegenerative disorders, cardiovascular disease, acute kidney injury, and metabolic disorders (such as obesity and non-alcoholic fatty liver disease). In this review, we introduce the structure, function, and regulation of ACSL4; discuss its role in apoptosis, ferroptosis, and autophagy; summarize its pathological function; and explore the potential implications of targeting ACSL4 in the treatment of various diseases.

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