Genetic variations in fetal and maternal tumor necrosis factor-α and interleukin 10: is there an association with preterm birth or periventricular leucomalacia?

Nuk, M; Orendi, K.; Rosenberger, Sarah; Griesbacher, Antonia; Holzapfel-Bauer, Margit; Resch, Bernhard; Lang, Uwe; Pertl, Barbara

doi:10.1038/jp.2011.37

Cited by 12 publications

(15 citation statements)

References 39 publications

(36 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“… 45 Three studies were conducted in preterm newborns with and without PVL, whose gestational age ranged from 26 to 32 weeks, and the sample ranged 18 to 36 newborns, with only one of these studies with term newborns as control group, such as this present study. 25 , 46 , 47 Results of these two studies showed that the prevalence of PVL was not affected by IL-10-1082G/A genotypes. 25 , 46 However, the third study showed that the GG genotype (anti-inflammatory cytokine high productor) was significantly associated with PVL reduced risk, 47 whose data are in agreement with the present study.…”

Section: Discussionmentioning

confidence: 91%

“… 25 , 46 , 47 Results of these two studies showed that the prevalence of PVL was not affected by IL-10-1082G/A genotypes. 25 , 46 However, the third study showed that the GG genotype (anti-inflammatory cytokine high productor) was significantly associated with PVL reduced risk, 47 whose data are in agreement with the present study. Interestingly, both studies showed the same number of cases with GG genotype, and PVL in these newborns did not persist for more than 7 days.…”

Section: Discussionmentioning

confidence: 91%

“…Therefore, TNF-α cytokine has been clearly involved in the pathogenesis of these injuries, including PVL. 3 , 20 , 21 , 23 , 25 , 40 – 42 …”

Section: Discussionmentioning

confidence: 99%

“…The T to C substitution at position −1031 in the TNF-α gene promoter region has been associated with high levels of TNF-α, and ∼60% of the difference in the production of TNF-α is genetically determined. 21 – 25 …”

Section: Introductionmentioning

confidence: 99%

“…The polymorphism at -1082 (G to A) is thought to be a major determinant of the magnitude of IL-10 secretion and may influence outcome in several disease states. 25 , 29 , 30 …”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

The association between pro- and anti-inflammatory cytokine polymorphisms and periventricular leukomalacia in newborns with hypoxic-ischemic encephalopathy

Gabriel¹,

Braga²,

Cardoso³

et al. 2016

JIR

View full text Add to dashboard Cite

BackgroundPeriventricular leukomalacia (PVL) is a frequent consequence of hypoxic-ischemic injury. Functional cytokine gene variants that result in altered production of inflammatory (tumor necrosis factor-alpha [TNF-α] and interleukin-1beta [IL-1β]) or anti-inflammatory (interleukin-10 [IL-10]) cytokines may modify disease processes, including PVL.ObjectiveThe aim of this study was to evaluate if there is a relationship between the two proinflammatory polymorphisms (TNF-α-1031T/C and IL-1β-511C/T) and the anti-inflammatory polymorphism IL-10-1082G/A and PVL risk in Brazilian newborns with and without this injury.Materials and methodsA cross-sectional case-control study performed at the Neonatal Intensive Care Unit of the Children’s Hospital and Maternity of the São José do Rio Preto Medical School (FAMERP). Fifty preterm and term newborns were examined as index cases and 50 term newborns as controls, of both sexes for both groups. DNA was extracted from peripheral blood leukocytes, and the sites that encompassed the three polymorphisms were amplified by polymerase chain reaction-restriction fragment length polymorphism.ResultsGestational age ranged from 25 to 39 weeks, in the case group, and in the control group it ranged from 38 to 42.5 weeks (P<0.0001). Statistically significant association was found between TNF-α-1031T/C high expression genotype TC (odds ratio [OR], 2.495; 95% confidence interval [CI], 1.10–5.63; P=0.043) as well as between genotypes (TC + CC) (OR, 2.471; 95% CI, 1.10–5.55; P=0.044) and risk of PVL. Statistically significant association was found between IL-1β-511C/T high expression genotypes (CT + TT) (OR, 23.120; 95% CI, 1.31–409.4; P=0.003) and risk of PVL. Statistically significant association between IL-10-1082G/A high expression genotype GG (OR, 0.07407; 95% CI, 0.02–0.34; P<0.0001) as well as between IL-10-1082G high expression allele (OR, 0.5098; 95% CI, 0.29–0.91; P=0,030) and PVL reduced risk was observed. There was a statistically significant association between TC/CT/GA genotype combination and the risk of PVL (OR, 6.469; 95% CI, 2.00–20.92; P=0.001).ConclusionThere is evidence of an association between the polymorphisms TNF-α-1031T/C, IL-1β-511C/T, and IL-10-1082G/A and PVL risk in this Brazilian newborn population studied.

show abstract

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 91%

“…Therefore, TNF-α cytokine has been clearly involved in the pathogenesis of these injuries, including PVL. 3 , 20 , 21 , 23 , 25 , 40 – 42 …”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…The polymorphism at -1082 (G to A) is thought to be a major determinant of the magnitude of IL-10 secretion and may influence outcome in several disease states. 25 , 29 , 30 …”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The association between pro- and anti-inflammatory cytokine polymorphisms and periventricular leukomalacia in newborns with hypoxic-ischemic encephalopathy

Gabriel¹,

Braga²,

Cardoso³

et al. 2016

JIR

View full text Add to dashboard Cite

show abstract

A MCP-1 promoter polymorphism at G-2518A is associated with spontaneous preterm birth

et al. 2014

View full text Add to dashboard Cite

Monocyte chemoattractant protein-1 (MCP-1) is an important chemokine involved in the pathogenesis of spontaneous preterm birth (SPTB). We examined whether the MCP-1 G-2518A polymorphism is associated with the risk of SPTB in a Chinese population. The MCP-1 G-2518A polymorphism was genotyped in 569 preterm singleton neonates and in 673 term neonates using polymerase chain reaction-restriction fragment length polymorphism analysis. The distribution of the MCP-1 G-2518A genotype and the allele frequencies between the SPTB patients and the controls were not significantly different in the overall sample. However, we found that the AA genotype was associated with significantly increased susceptibility to very SPTB (<32 weeks) [odds ratio (OR) 2.07; 95 % confidence interval (CI), 1.27-3.36; P = 0.005) and extremely SPTB (<28 weeks) (OR 2.74; 95 % CI, 1.10-6.72; P = 0.014) compared with -2518G-positive genotypes (GG + GA genotypes). When extremely preterm neonates and very preterm neonates were combined, the AA genotype was also significantly associated with increased susceptibility to SPTB (OR 2.23; 95 % CI, 1.40-3.54; P < 0.001). The MCP-1 G-2518A polymorphism was not associated with increased susceptibility to SPTB in patients with premature rupture of the membranes (PROM) or in those without PROM. Our findings suggest that the MCP-1 G-2518A polymorphism may plays a role in mediating the susceptibility to SPTB in the Chinese population. Knowledge of genetic factors contributing to the pathogenesis of SPTB may have implications for screening and treatment of this disorder.

show abstract

Association of IL-10 Gene Polymorphism (−819C > T, −592C > A and −1082G > A) with Preterm Birth

et al. 2017

View full text Add to dashboard Cite

show abstract

Genetic variations in fetal and maternal tumor necrosis factor-α and interleukin 10: is there an association with preterm birth or periventricular leucomalacia?

Cited by 12 publications

References 39 publications

The association between pro- and anti-inflammatory cytokine polymorphisms and periventricular leukomalacia in newborns with hypoxic-ischemic encephalopathy

The association between pro- and anti-inflammatory cytokine polymorphisms and periventricular leukomalacia in newborns with hypoxic-ischemic encephalopathy

A MCP-1 promoter polymorphism at G-2518A is associated with spontaneous preterm birth

Association of IL-10 Gene Polymorphism (−819C > T, −592C > A and −1082G > A) with Preterm Birth

Contact Info

Product

Resources

About