Genetic variations at microRNA and processing genes and risk of oral cancer

Roy, Roshni; Sarkar, Navonil De; Ghose, Sandip; Paul, Ranjan Rashmi; Pal, Mousumi; Bhattacharya, Chandrika; Chowdhury, Shweta K Roy; Ghosh, Saurabh; Roy, Bidyut

doi:10.1007/s13277-013-1450-3

Cited by 29 publications

(23 citation statements)

References 28 publications

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“…So, it needs to be investigated whether these two SNPs are in LD. In our recent study on cancer patients, we got similar results for Gemin3 and mir-34b [13]. It is interesting to study how these two polymorphisms alter risk of both oral precancer and cancer.…”

Section: Discussionsupporting

confidence: 67%

Association between risk of oral precancer and genetic variations in microRNA and related processing genes

Roy

Sarkar

Ghose³

et al. 2014

J Biomed Sci

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BackgroundMicroRNAs have been implicated in cancer but studies on their role in precancer, such as leukoplakia, are limited. Sequence variations at eight miRNA and four miRNA processing genes were studied in 452 healthy controls and 299 leukoplakia patients to estimate risk of disease.ResultsGenotyping by TaqMan assay followed by statistical analyses showed that variant genotypes at Gemin3 and mir-34b reduced risk of disease [OR = 0.5(0.3–0.9) and OR = 0.7(0.5–0.9) respectively] in overall patients as well as in smokers [OR = 0.58(0.3–1) and OR = 0.68(0.5–0.9) respectively]. Among chewers, only mir29a significantly increased risk of disease [OR = 1.8(1–3)]. Gene-environment interactions using MDR-pt program revealed that mir29a, mir34b, mir423 and Xpo5 modulated risk of disease (p < 0.002) which may be related to change in expression of these genes as observed by Real-Time PCR assays. But association between polymorphisms and gene expressions was not found in our sample set as well as in larger datasets from open access platforms like Genevar and 1000 Genome database.ConclusionVariations in microRNAs and their processing genes modulated risk of precancer but further in-depth study is needed to understand mechanism of disease process.

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Section: Discussionsupporting

confidence: 67%

Association between risk of oral precancer and genetic variations in microRNA and related processing genes

Roy

Sarkar

Ghose³

et al. 2014

J Biomed Sci

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“…Following the study selection criteria, 107 studies were excluded in the first step of title and duplicate screening step, and 16 studies were subsequently excluded from our research due to various deficiencies(3 were reviews, 5 were not on the research polymorphism locus, and 8 were focused on cell line and others). In total, 11 eligible articles were selected with adequate data 27 33 34 35 36 37 38 39 40 41 42 , including seven studies on microRNA-146a rs2910164 G > C 27 34 35 36 37 38 40 , five studies on microRNA-196a2 rs11614913 C > T 33 34 35 41 42 , three publications on microRNA-149 rs2292832 C > T 34 35 39 , and two studies on microRNA-499 rs3746444 A > G 34 35 , respectively. Four studies involved Caucasian populations 27 33 34 37 , and seven studies involved Asian populations 35 36 38 39 40 41 42 .…”

Section: Resultsmentioning

confidence: 99%

“…In total, 11 eligible articles were selected with adequate data 27 33 34 35 36 37 38 39 40 41 42 , including seven studies on microRNA-146a rs2910164 G > C 27 34 35 36 37 38 40 , five studies on microRNA-196a2 rs11614913 C > T 33 34 35 41 42 , three publications on microRNA-149 rs2292832 C > T 34 35 39 , and two studies on microRNA-499 rs3746444 A > G 34 35 , respectively. Four studies involved Caucasian populations 27 33 34 37 , and seven studies involved Asian populations 35 36 38 39 40 41 42 . Regarding the genotyping method, eight studies used the Applied Biosystems 27 33 35 36 39 40 41 42 , two studies adopted polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) 34 35 , one study used PCR with two-pair primers method 37 and another was conducted with the MassARRAY iPLEX platform 38 .…”

Section: Resultsmentioning

confidence: 99%

Significant association between functional microRNA polymorphisms and head and neck cancer susceptibility: a comprehensive meta-analysis

Niu

Du²,

Lu³

et al. 2015

Sci Rep

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Molecular epidemiological studies have showed a closer association between microRNA polymorphisms with and head and neck cancer (HNC) risk. But the results of these studies were inconsistent. We performed this meta-analysis to clarify the associations between microRNA polymorphisms and HNC risk. Four electronic databases (PubMed, Embase, CNKI, and Wanfang) were searched. Odds ratios (ORs) with 95% confidence interval (CIs) were calculated to assess the association between microRNA-146a rs2910164 G > C, microRNA-196a2 rs11614913 C > T, microRNA-149 rs2292832 C > T, microRNA-499 rs3746444 A > G polymorphisms and HNC risk. Heterogeneity, publication bias and sensitivity analysis were conducted to guarantee the statistical power. Overall, 11 selected articles involving 16100 subjects were included in this meta-analysis. Significantly increased risk between microRNA-146a rs2910164 G > C polymorphism and HNC risk were observed in Caucasian population (GC vs. GG: OR = 1.31, 95%CI = 1.01–1.68; GC + CC vs. GG: OR = 1.26, 95%CI = 1.02–1.57). For microRNA-196a2 rs11614913 C > T, similarly increased risk were also found in Asian population (T vs. C, OR = 1.14, 95%CI = 1.04–1.25; TT vs. CC, OR = 1.33, 95%CI = 1.09–1.61; CT + TT vs. CC OR = 1.32, 95%CI = 0.99–1.76; TT vs. CC + CT, OR = 1.14, 95%CI = 0.99–1.33). In addition, no significant association was detected between microRNA-149 rs2292832 C > T and microRNA-499 rs3746444 A > G polymorphism and HNC risk. This meta-analysis demonstrates that microRNA polymorphisms are associated with HNC development based on ethnicity diversity.

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“…It has also been observed that miRNAs could have played important roles in tumor development, diagnosis and prognosis (5). Studies have demonstrated that the single-nucleotide polymorphisms (SNPs) or mutations in miRNA-coding genes functionally affected the expression and biogenesis of mature miRNAs and their target genes, consequently contributing to cancer susceptibility (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Association of the pri-miR-124-1 rs531564 polymorphism with cancer risk: A meta-analysis

Fang

Zeng

et al. 2015

Molecular and Clinical Oncology

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Abstract.Recently, several studies regarding the association between the pri-miR-124-1 rs531564 polymorphism and cancer susceptibility were explored. Owing to inconsistent results of these studies, a meta-analysis was conducted to determine the association of this polymorphism with cancer risk. Relevant studies were identified by a systematic search of PubMed, EMBASE, Web of Science and CNKI on-line databases. Odds ratios (ORs) and 95% confidence intervals (CIs) from eligible studies were pooled, and heterogeneity and publication bias were also evaluated. A total of five studies with 2,253 cases and 2,510 controls were included in the meta-analysis. Overall, the results showed that the pri-miR-124-1 rs531564 polymorphism was significantly associated with a reduced cancer risk (G vs. C: OR, 0.86; 95% CI, 0.77-0.96; GG vs. CC: OR, 0.52; 95% CI, 0.34-0.79; GG vs. CG/CC: OR, 0.54; 95% CI, 0.36-0.81). Furthermore, in the subgroup analysis by cancer sites, a statistical association was identified between the rs531564 polymorphism and a decreased esophageal squamous cell carcinoma (ESCC) risk (G vs. C: OR, 0.87; 95% CI, 0.77-0.98; GG vs. CC: OR, 0.54; 95% CI, 0.34-0.84). These findings suggested that the genetic variant of rs531564 may have a potential value in decreasing cancer risk, particularly in ESCC patients.

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Genetic variations at microRNA and processing genes and risk of oral cancer

Cited by 29 publications

References 28 publications

Association between risk of oral precancer and genetic variations in microRNA and related processing genes

Association between risk of oral precancer and genetic variations in microRNA and related processing genes

Significant association between functional microRNA polymorphisms and head and neck cancer susceptibility: a comprehensive meta-analysis

Association of the pri-miR-124-1 rs531564 polymorphism with cancer risk: A meta-analysis

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