Genetic variations and risk of placental abruption: A genome-wide association study and meta-analysis of genome-wide association studies

Workalemahu, Tsegaselassie; Enquobahrie, Daniel A.; Gelaye, Bizu; Sánchez, Sixto E.; García, Pedro J.; Tekola‐Ayele, Fasil; Hajat, Anjum; Thornton, Timothy A.; Ananth, Cande V.; Williams, Michelle A.

doi:10.1016/j.placenta.2018.04.008

Cited by 17 publications

(8 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gene expression knowledge continues to guide scientists in search for what can control the levels of sFLt1 for effective treatment of preeclampsia. For example, ABCC8, KCNJ11, and ADAM12 are other genes implicated during pregnancy in a case of placental abruption [16,17].…”

Section: Placental Multi-omics For Understanding Preeclampsiamentioning

confidence: 99%

“…Placental Abruption [17,19] | Gestational Diabetes [25] | Asthma in Offspring [52,55] Spearman Rank Correlations Preeclampsia [23,27] | Metabolic Syndrome [45] Post Hoc Analyses Respiratory syncytial virus [4] | Preeclampsia [21,29] | Asthma in Offspring [52] Linear Regression Model (including Mixed Effect Model) Maternal Cardiovascular Adaptation [3] | Preeclampsia [23] | Asthma in Offspring [53] Kaplan-Meier Curve Asthma in Offspring [52,53] Kolmogorov-Smirnov Test Preeclampsia [21] | Gestational Diabetes [26] Principal Component Analysis (PCA) Preeclampsia [12] | Metabolic Dynamics of Timing of Delivery [18] Cox Regression Asthma in Offspring [52,53] Pearson Correlation Coefficient Obesity and Overweight [44] Table 1. Statistical methods and machine learning techniques are used in pregnancy literature.…”

Section: T-testmentioning

confidence: 99%

“…Preeclampsia [12,23,29] | Placental Abruption [19] | Preterm Delivery [28] Asthma in Offspring [52,53] ANOVA Preeclampsia [12,21], [27,29] | Placental Abruption [17] | Metabolic Syndrome [45] Asthma in Offspring [52] ROC Analysis…”

Section: T-testmentioning

confidence: 99%

See 2 more Smart Citations

Molecular epidemiology of pregnancy using omics data: advances, success stories, and challenges

Rahnavard

Chatterjee

Wen

et al. 2022

Preprint

View full text Add to dashboard Cite

Multi-omics approaches have been successfully applied to investigate pregnancy and health outcomes at a molecular and genetic level in several studies. As omics technologies advance, research areas are open to study further. Here we discuss overall trends and examples of successfully using omics technologies and techniques (e.g., genomics, proteomics, metabolomics, and metagenomics) to investigate the molecular epidemiology of pregnancy. In addition, we outline omics applications and study characteristics of pregnancy for understanding fundamental biology, causal health and physiological relationships, risk and prediction modeling, diagnostics, and correlations. Overarching goal: To detail the utility of multi-omics approaches in the study of pregnancy physiology and disease.

show abstract

Section: Placental Multi-omics For Understanding Preeclampsiamentioning

confidence: 99%

Section: T-testmentioning

confidence: 99%

See 1 more Smart Citation

Molecular epidemiology of pregnancy using omics data: advances, success stories, and challenges

Rahnavard

Chatterjee

Wen

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Additional analyses performed by the authors revealed that the majority those genes are connected to trophoblast-like cell interaction, or in the endocrine or cardiovascular systems or cellular function pathways. However, their role still needs further research [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Molecular Changes on Maternal–Fetal Interface in Placental Abruption—A Systematic Review

Bączkowska

Zgliczyńska

Faryna³

et al. 2021

IJMS

View full text Add to dashboard Cite

Placental abruption is the separation of the placenta from the lining of the uterus before childbirth. It is an infrequent perinatal complication with serious after-effects and a marked risk of maternal and fetal mortality. Despite the fact that numerous placental abruption risk factors are known, the pathophysiology of this issue is multifactorial and not entirely clear. The aim of this review was to examine the current state of knowledge concerning the molecular changes on the maternal–fetal interface occurring in placental abruption. Only original research articles describing studies published in English until the 15 March 2021 were considered eligible. Reviews, book chapters, case studies, conference papers and opinions were excluded. The systematic literature search of PubMed/MEDLINE and Scopus databases identified 708 articles, 22 of which were analyzed. The available evidence indicates that the disruption of the immunological processes on the maternal–fetal interface plays a crucial role in the pathophysiology of placental abruption. The features of chronic non-infectious inflammation and augmented immunological cytotoxic response were found to be present in placental abruption samples in the reviewed studies. Various molecules participate in this process, with only a few being examined. More advanced research is needed to fully explain this complicated process.

show abstract

“…Maternal complications include haemorrhagic shock, coagulopathy and disseminated intravascular coagulation, uterine rupture, renal failure and ischemic necrosis of distal organs. 5,6 Neonatal complications include death and neuro-developmental problems. 7 Clinicians confronted with severe abruption and a live fetus has the dilemma of balancing unstable individual with a possible coagulopathy versus possible risks of increased mortality and severe morbidity to the fetus of delay.…”

Section: Introductionmentioning

confidence: 99%

Fetomaternal Outcome in Placental Abruption

Siddique¹,

Afridi²,

Riaz³

et al. 2021

PJMHS

View full text Add to dashboard Cite

Background: Placental abruption is a major contributor to obstetrical haemorrhage and a major cause of perinatal mortality in developing countries. This has been done to an attempt to recognize this condition at an earlier stage, prevent its complications and properly manage the complications if they do occur. Aim: To determine maternal and fetal outcome in females with placental abruption. Methods: Hundred patients with confirmed diagnosis of placental abruption were divided in three categories according to the grade of placental abruption. Their baseline investigations including blood group, haemoglobin and coagulation profile i.e. partial thromboplastin time, activated partial thromboplastin time, serum fibrinogen and FDP's were performed and recorded for each category separately. The effect of each grade of abruption was studied on maternal and fetal outcome as well as extent of coagulation disturbance. Results: The results of the study show that 66% babies were delivered alive and 34% were IUD/stillbirth. Gestational age at presentation was important in fetal outcome. Out of 30 babies presenting before 32 weeks of gestation 66% were IUD/stillbirth. 58% patients delivered vaginally and 42% had caesarean section. 32% patients had grade I abruption, 34% patients had grade 3 abruption. 18% patients had post-partum haemorrhage. Conclusion: All professionals working in labour ward must be aware of the causes, presentation and complications of disease and appropriate measures taken in time can help reduce the maternal and neonatal morbidity and mortality. Keywords: Placental abruption, maternal outcome, foetal outcome, coagulation disturbance

show abstract

Genetic variations and risk of placental abruption: A genome-wide association study and meta-analysis of genome-wide association studies

Abstract: We identified several genetic loci and related functions that may play a role in PA risk. Understanding genetic factors underlying pathophysiological mechanisms of PA may facilitate prevention and early diagnostic efforts.

Cited by 17 publications

References 53 publications

Molecular epidemiology of pregnancy using omics data: advances, success stories, and challenges

Molecular epidemiology of pregnancy using omics data: advances, success stories, and challenges

Molecular Changes on Maternal–Fetal Interface in Placental Abruption—A Systematic Review

Fetomaternal Outcome in Placental Abruption

Contact Info

Product

Resources

About