Genetic variation underlying resistance to infectious hematopoietic necrosis virus in a steelhead trout (Oncorhynchus mykiss) population

Brieuc, Marine S. O.; Purcell, Maureen K.; Palmer, Alexander D.; Naish, Kerry A.

doi:10.3354/dao02933

Cited by 10 publications

(17 citation statements)

References 39 publications

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“…Infectious hematopoietic necrosis (IHN) is an important disease of salmonid fish that is caused by IHN virus (IHNV), which is a single-stranded negative-sense RNA rhabdovirus (1). IHNV is endemic to the Pacific Northwest in North America (2) and has spread through continental Europe, China, and Japan (3)(4)(5). IHNV is infectious to Pacific salmon and trout (Oncorhynchus spp.…”

Section: Introductionmentioning

confidence: 99%

“…IHNV is infectious to Pacific salmon and trout (Oncorhynchus spp. ), as well as to Atlantic salmon (Salmo salar) (2), and can cause significant mortality and losses at nearly all stages of production in commercial aquaculture settings (6)(7)(8). Currently, unfortunately, there is no confirmed and cost-effective method for IHNV prevention or treatment.…”

Section: Introductionmentioning

confidence: 99%

“…The additive genetic basis for IHNV resistance is evident from the moderate estimates of heritability for IHNV binary survival status (h 2 = 0.23-0.55) and survival days to death (h 2 = 0.02-0.20) in a steelhead trout population (2). Recently, we also found moderate estimates of heritability for IHNV binary survival status (h 2 = 0.25-0.28) and survival days to death (h 2 = 0.23-0.33) in a commercial rainbow trout breeding population (8).…”

Section: Introductionmentioning

confidence: 99%

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Assessing Accuracy of Genomic Predictions for Resistance to Infectious Hematopoietic Necrosis Virus With Progeny Testing of Selection Candidates in a Commercial Rainbow Trout Breeding Population

et al. 2020

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Assessing Accuracy of Genomic Predictions for Resistance to Infectious Hematopoietic Necrosis Virus With Progeny Testing of Selection Candidates in a Commercial Rainbow Trout Breeding Population

et al. 2020

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“…The IHNV pathogen–host system has a complex disease ecology that involves multiple host species, each with differing susceptibilities and genetically distinct subpopulations, and a rapidly evolving virus covering a wide range of virulence profiles (Breyta et al., ; Breyta, McKenney, et al., ; Brieuc, Purcell, Palmer, & Naish, ; Garver, Conway, & Kurath, ; LaPatra, Fryer, & Rohovec, ; Peñaranda et al., , ; Purcell et al., ). Wild‐ and semi‐cultured hatchery populations are often conspecific within species, and sympatric among species, but their pathogen transmission routes are largely uncharacterized.…”

Section: Discussionmentioning

confidence: 99%

“…The IHNV pathogen-host system has a complex disease ecology that involves multiple host species, each with differing susceptibilities and genetically distinct subpopulations, and a rapidly evolving virus covering a wide range of virulence profiles (Breyta et al, 2014;Breyta, McKenney, et al, 2016;Brieuc, Purcell, Palmer, & Naish, 2015;Garver, Conway, & Kurath, 2006;LaPatra, Fryer, & Rohovec, 1993;Peñaranda et al, 2009Peñaranda et al, , 2011Purcell et al, 2009) in disease outbreaks can be urgent and thus, analysis and interpretation must be performed despite these caveats (Wasserberg, Osnas, Rolley, & Samuel, 2009). The dataset presented here is comprehensive in its scope, including all regional agencies operating within the study area, and it is unique in analyzing both positive/negative and genetic surveillance records of an aquatic pathogen.…”

Section: Discussionmentioning

confidence: 99%

Transmission routes maintaining a viral pathogen of steelhead trout within a complex multi‐host assemblage

Breyta

Brito

Ferguson

et al. 2017

Ecology and Evolution

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This is the first comprehensive region wide, spatially explicit epidemiologic analysis of surveillance data of the aquatic viral pathogen infectious hematopoietic necrosis virus (IHNV) infecting native salmonid fish. The pathogen has been documented in the freshwater ecosystem of the Pacific Northwest of North America since the 1950s, and the current report describes the disease ecology of IHNV during 2000–2012. Prevalence of IHNV infection in monitored salmonid host cohorts ranged from 8% to 30%, with the highest levels observed in juvenile steelhead trout. The spatial distribution of all IHNV‐infected cohorts was concentrated in two sub‐regions of the study area, where historic burden of the viral disease has been high. During the study period, prevalence levels fluctuated with a temporal peak in 2002. Virologic and genetic surveillance data were analyzed for evidence of three separate but not mutually exclusive transmission routes hypothesized to be maintaining IHNV in the freshwater ecosystem. Transmission between year classes of juvenile fish at individual sites (route 1) was supported at varying levels of certainty in 10%–55% of candidate cases, transmission between neighboring juvenile cohorts (route 2) was supported in 31%–78% of candidate cases, and transmission from adult fish returning to the same site as an infected juvenile cohort was supported in 26%–74% of candidate cases. The results of this study indicate that multiple specific transmission routes are acting to maintain IHNV in juvenile fish, providing concrete evidence that can be used to improve resource management. Furthermore, these results demonstrate that more sophisticated analysis of available spatio‐temporal and genetic data is likely to yield greater insight in future studies.

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Phylogenetic analysis and genotyping of Iranian infectious haematopoietic necrosis virus (IHNV) of rainbow trout (Oncorhynchus mykiss) based on the glycoprotein gene

Kafi

Ghalyanchilangeroudi

Nikaein

et al. 2022

Veterinary Medicine & Sci

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Background: Infectious haematopoietic necrosis (IHN) is known as one of the most contagious systemic viral diseases in salmonids which can lead to significant mortality rates and negative impacts on the salmonid farming industry. Infectious haematopoietic necrosis virus (IHNV) was first detected in rainbow trout (Oncorhynchus mykiss) farms in Iran in 2003. Objectives: We conducted the present study to determine the detection of IHN genotypes in rainbow trout (O. mykiss) in farms in the central parts of Iran, using molecular and phylogenetic techniques.Methods: Samples were collected from fries exhibiting clinical signs such as darkening of the skin, abdominal swelling, and loss of appetite. Phylogenetic analysis was performed by the neighbour-joining method, using MEGA 5.1 software. For phylogenetic analysis and genotyping of IHNV from central parts of Iran, the sequences of the glycoprotein gene were determined for two Iranian isolates (Jahad-UT1 and Jahad-UT2).Results: Phylogenetic analysis revealed that the detected strains (Jahad-UT1 and Jahad-UT2 isolates) are closely related (97.23%-100%) to European isolates within genogroup 'E' . Conclusions:This finding indicates that Jahad-UT1 and Jahad-UT2 isolates have been widely transferred to Iran from European countries. Moreover, the nucleotide diversity of these Iranian isolates showed a close relationship with the North American and Asian isolates, although the Iranian isolates were collected from a smaller geographical area and within a shorter time period between 2014 and 2015.

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Genetic variation underlying resistance to infectious hematopoietic necrosis virus in a steelhead trout (Oncorhynchus mykiss) population

Cited by 10 publications

References 39 publications

Assessing Accuracy of Genomic Predictions for Resistance to Infectious Hematopoietic Necrosis Virus With Progeny Testing of Selection Candidates in a Commercial Rainbow Trout Breeding Population

Assessing Accuracy of Genomic Predictions for Resistance to Infectious Hematopoietic Necrosis Virus With Progeny Testing of Selection Candidates in a Commercial Rainbow Trout Breeding Population

Transmission routes maintaining a viral pathogen of steelhead trout within a complex multi‐host assemblage

Phylogenetic analysis and genotyping of Iranian infectious haematopoietic necrosis virus (IHNV) of rainbow trout (Oncorhynchus mykiss) based on the glycoprotein gene

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