Genetic variation-optimized treatment benefit of angiotensin-converting enzyme inhibitors in patients with stable coronary artery disease

Lee, Jen‐Kuang; Wu, Cho Kai; Tsai, Chia Ti; Lin, Lian‐Yu; Lin, Jou‐Wei; Chien, Kuo–Liong; Hwang, Juey‐Jen; Lin, Chunn-Lee; Tseng, Chuen-Den; Chiang, Fu-Tien

doi:10.1097/fpc.0b013e32835a0ffa

Cited by 9 publications

(4 citation statements)

References 37 publications

(41 reference statements)

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“…Lee et al also reported that ACEI was associated with lower risk for ISR and subsequently lower need for revascularization. Moreover, it indicated that DD genotype of ACE gene was correlated with higher incidence for revascularization [21].…”

Section: Discussionmentioning

confidence: 98%

Effect of angiotensin converting enzyme gene polymorphism on patients with in-stent restenosis after percutaneous coronary intervention

Abdelaziz¹,

Mohamed²,

Balata³

et al. 2022

Trop. J. Pharm Res

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Purpose: To evaluate the association between common single nucleotide polymorphisms (SNPs) in angiotensin converting enzyme (ACE) gene and the risk of in-stent restenosis (ISR) and/or the response to angiotensin converting enzyme inhibitor ACEI in individuals with stable coronary artery disease (CAD) after stent implantation. Methods: The total population of this study consisted of 200 Egyptian individuals divided into 2 groups - in-stent restenosis (ISR) and non ISR group). Genomic DNA was withdrawn from EDTA whole blood applying a spin column approach and ACE gene insertion/deletion (I/D) polymorphisms were determined by polymerase chain reaction (PCR). Results: Carriers of allele D of ACE gene were significantly more liable to ISR occurrence. However, carriers of allele I were significantly more liable to ISR occurrence after administration of ACEI. There is a negative interaction between DD genotype of ACE gene and ACEI administration on ISR after percutaneous coronary intervention (PCI). However, there is a positive interaction between II and ID genotype of ACE gene and ACEI administration on ISR after PCI with bare metal stents (BMS). Conclusion: It is beneficial to implement ACEI in therapeutic regimen in individuals with ID or II genotypes of ACE gene, especially with BMS implementation.

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Section: Discussionmentioning

confidence: 98%

Effect of angiotensin converting enzyme gene polymorphism on patients with in-stent restenosis after percutaneous coronary intervention

Abdelaziz¹,

Mohamed²,

Balata³

et al. 2022

Trop. J. Pharm Res

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“…The I allele, which represents an insertion of 287-base pair (bp), is associated with lower serum and tissue, and the deleted form of the variant (D allele) is associated with higher circulating and tissue ACE activity [ 19 , 20 ]. This genetic polymorphism was associated with coronary artery disease [ 21 ], systemic lupus erythematosus [ 22 ] and cancer risk [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Correlation of angiotensin I-converting enzyme gene insertion/deletion polymorphism with rheumatic heart disease: a meta-analysis

Tian

et al. 2016

Bioscience Reports

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Rheumatic heart disease (RHD) is a serious cardiovascular disorder worldwide. Several articles have reported the effect of angiotensin I-converting enzyme gene insertion/deletion (ACE I/D) polymorphism in RHD risk. However, the results still remain inconsistent. The objective of the present study was to assess more precise estimations of the relationship between ACE I/D variant and RHD susceptibility. Relevant case–control studies published between January 2000 and 2016 were searched in the electronic databases. The odds ratio (OR) with its 95% confidence interval (CI) was employed to calculate the strength of the effect. A total of nine articles were retrieved, including 1333 RHD patients and 1212 healthy controls. Overall, our result did not detect a significant association between ACE I/D polymorphism and RHD risk under each genetic model (P > 0.05). Subgroup analysis by ethnicity showed no positive relationship in Asians as well (P > 0.05). With respect to the severity of RHD, our result found that the frequency differences between mitral valve lesion (MVL), combined valve lesion (CVL) and healthy controls were not significantly different. Furthermore, no significant association was found between female, male RHD patients and the controls regarding to the ACE I/D polymorphism. In conclusion, our result indicated that ACE I/D polymorphism might not be a risk factor for RHD progression based on the existing research results. Additional well-designed studies with larger samples are still needed to confirm these findings.

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“…Among the wide range of candidate genes, structural polymorphism of which may have a prognostic value in development and progression of congestive heart failure, special attention in current studies is directed to genes of components of rennin-angiotensin-aldosteron system and counterregulatory systems, including β-adrenoreceptors genes [3].…”

mentioning

confidence: 99%

Genetic Aspects of Development and Progression of Congestive Heart Failure in Patients With Ischemic Heart Disease and Obesity∗

Kadykova

2016

PEP

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In this article elucidated the influence of allelic polymorphism of Gln27Glu of β2-adrenoceptors gene on patients that have coronary heart disease and obesity on the expansion and progression of congestive heart failure and left ventricular systolic dysfunction by surveying 222 patients. Presence of C allel of polymorphous locus Gln27Glu of β2-adrenoreceptors gene in patients with ischemic heart disease and concomitant obesity was associated with decreased risk of development of congestive heart failure (p < 0.05). The obtained data shown the absence of influence of polymorphous variants of β2-adrenoreceptors gene on progression of congestive heart failure in patients with ischemic heart disease and obesity (p > 0.05).

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Genetic variation-optimized treatment benefit of angiotensin-converting enzyme inhibitors in patients with stable coronary artery disease

Abstract: ACE inhibitors were associated with a significant decrease in MACE in Chinese patients diagnosed with CAD. Genetic variants were also associated with event-free survival, but their effects were modified by the use of ACE inhibitors.

Cited by 9 publications

References 37 publications

Effect of angiotensin converting enzyme gene polymorphism on patients with in-stent restenosis after percutaneous coronary intervention

Effect of angiotensin converting enzyme gene polymorphism on patients with in-stent restenosis after percutaneous coronary intervention

Correlation of angiotensin I-converting enzyme gene insertion/deletion polymorphism with rheumatic heart disease: a meta-analysis

Genetic Aspects of Development and Progression of Congestive Heart Failure in Patients With Ischemic Heart Disease and Obesity∗

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