Genetic variation of RNF145 gene and blood lipid levels in Xinjiang population, China

Ming, Jian; Wei, Xian; Han, Moonsik; Adi, Dilare; Abuzhalihan, Jialin; Wang, Yongtao; Yang, Yi‐Ning; Li, Xiaomei; Xie, Xiang; Fu, Zhen-Yan; Gai, Min-Tao; Ma, Yun

doi:10.1038/s41598-021-85503-z

Cited by 4 publications

(7 citation statements)

References 32 publications

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“…In Figure 6 (B), we summarize the BRIGHT-identified gene regions, providing only representative groups of the identified SNPs in each region. We note that genes, LINC01185 (Villarreal-Martínez et al, 2016), IL13 (Eder et al, 2011), TNIP1 (Bowes et al, 2011), RNF145 (Ming et al, 2021), genes in MHC region (Ozawa et al, 1988;Tiilikainen et al, 1980), TRAF3IP2 (Hüffmeier et al, 2010), TNFAIP3 (Tejasvi et al, 2012) and NOS2 (Garzorz and Eyerich, 2015), were previously reported with important contributions to the development of psoriasis.…”

Section: Real Data Applicationsmentioning

confidence: 61%

Bregman Divergence-Based Data Integration with Application to Polygenic Risk Score (PRS) Heterogeneity Adjustment

Qinmengge¹,

Patrick²,

Zhang³

et al. 2022

Preprint

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Polygenic risk scores (PRS), developed as the sum of single-nucleotide polymorphisms (SNPs) weighted by the risk allele effect sizes as estimated by published genome-wide association studies, have recently received much attention for genetics risk prediction. While successful for the Caucasian population, the PRS based on the minority population cohorts suffer from limited event rates, small sample sizes, high dimensionality and low signal-to-noise ratios, exacerbating already severe health disparities. Due to population heterogeneity, direct trans-ethnic prediction by utilizing the Caucasian model for the minority population also has limited performance. As a result, it is desirable to design a data integration procedure to measure the difference between the populations and optimally balance the information from them to improve the prediction stability of the minority populations. A unique challenge here is that due to data privacy, the individual genotype data is not accessible for either the Caucasian population or the minority population. Therefore, new data integration methods based only on encrypted summary statistics are needed. To address these challenges, we propose a BRegman divergence-based Integrational Genetic Hazard Transethnic (BRIGHT) estimation procedure to transfer the information we learned from PRS across different ancestries.The proposed method only requires the use of published summary statistics and can be applied to improve the performance of PRS for ethnic minority groups, accounting for challenges including potential model misspecification, data heterogeneity and data sharing constraints. We provide the asymptotic consistency and weak oracle property for the proposed method. Simulations show the prediction and variable selection advantages of the proposed method when applied to heterogeneous datasets. Real data analysis constructing psoriasis PRS scores for a South Asian population also confirms the improved model performance.

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Section: Real Data Applicationsmentioning

confidence: 61%

Bregman Divergence-Based Data Integration with Application to Polygenic Risk Score (PRS) Heterogeneity Adjustment

Qinmengge¹,

Patrick²,

Zhang³

et al. 2022

Preprint

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“…This result is in accordance with research conducted in Xinjiang China that the average age of patients with heart disease is 34.12 years. 14 Adult age is a productive age to work, it is the period at which an increase in welfare begins. As a result, lifestyle changes occur, such as changes in eating habits.…”

Section: Discussionmentioning

confidence: 99%

“…The indirect effect of exogenous variable on early mobilization is 34.12 years 14. Adult age is a productive age to work, it is the period at which an increase in welfare begins.…”

mentioning

confidence: 99%

The Effect of a Smartphone-Based Perioperative Nursing Intervention: Prayer, Education, Exercise Therapy, Hypnosis, and Music toward Pain, Anxiety, and Early Mobilization on Cardiac Surgery

Awaludin

Nurachmah

Soetisna

et al. 2022

Journal of Public Health Research

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Background: Cardiac surgery can elicit both physical and psychological responses. Prayer, exercise therapy, education, hypnosis, and music are expected to be able to overcome pain, anxiety, and immobilization in the cardiac surgery. This study was to create a smartphone-based peri-operative nursing intervention model that was able to reduce pain, anxiety, and increase early mobilization cardiac surgery patients.Design and Methods: This study consisted of three stages. The first stage was research and development, the second was true experimental design, and the third was cross sectional design. The samples size was 86 respondents. The intervention models for the treatment group comprised of a smartphone-based therapy of prayer, education, exercise, hypnosis, and music. The control group was given standard hospital intervention according to the clinical pathway.Results: The majority of respondents were adults, male, high school graduate in the treatment group and bachelor graduate in the control group, CABG type of surgery, and having pain history. The intervention had a significant effect on reducing pain scale and anxiety level as well as increasing early mobilization (p<0.05). The intervention had a direct effect on pain and anxiety, but it had no direct effect on early mobilization. However, it gave indirect effect on early mobilization that was mediated by anxiety.Conclusion: The models can be used by nurses to reduce pain, anxiety and to increase early mobilization on cardiac surgery patients.

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“…Single nucleotide polymorphisms within RNF145's coding region in humans are associated with obesity and dyslipidemia while its differential expression in hepatocellular carcinoma affects disease progression. [74][75][76][77] RNF145's lipid-modulating effects are intimately linked to its ability to target lipid metabolic enzymes for degradation. [74,[78][79][80][81] Accordingly, RNF145's substrates include the ER-resident lipid hydrolase adiponectin receptor 2 (ADIPOR2) and the cholesterol biosynthetic enzyme HMGCR.…”

Section: Rnf145mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

As a matter of fat: Emerging roles of lipid‐sensitive E3 ubiquitin ligases

Gawden‐Bone,

Lehner,

Volkmar

2023

BioEssays

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The dynamic structure and composition of lipid membranes need to be tightly regulated to control the vast array of cellular processes from cell and organelle morphology to protein‐protein interactions and signal transduction pathways. To maintain membrane integrity, sense‐and‐response systems monitor and adjust membrane lipid composition to the ever‐changing cellular environment, but only a relatively small number of control systems have been described. Here, we explore the emerging role of the ubiquitin‐proteasome system in monitoring and maintaining membrane lipid composition. We focus on the ER‐resident RNF145 E3 ubiquitin ligase, its role in regulating adiponectin receptor 2 (ADIPOR2), its lipid hydrolase substrate, and the broader implications for understanding the homeostatic processes that fine‐tune cellular membrane composition.

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Genetic variation of RNF145 gene and blood lipid levels in Xinjiang population, China

Cited by 4 publications

References 32 publications

Bregman Divergence-Based Data Integration with Application to Polygenic Risk Score (PRS) Heterogeneity Adjustment

Bregman Divergence-Based Data Integration with Application to Polygenic Risk Score (PRS) Heterogeneity Adjustment

The Effect of a Smartphone-Based Perioperative Nursing Intervention: Prayer, Education, Exercise Therapy, Hypnosis, and Music toward Pain, Anxiety, and Early Mobilization on Cardiac Surgery

As a matter of fat: Emerging roles of lipid‐sensitive E3 ubiquitin ligases

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