Genetic variation of mitochondrial sequence-hv2 in Vietnamese populations

Hung, Do Manh; Hà, Nguyễn Hải; Khoi, Pham Nhat; Nhung, Vũ Phương; Phong, Nguyen Van; Dương, Nguyễn Thùy; Hải, Nông Văn; Ton, Nguyen Dang

doi:10.15625/0866-7160/v38n2.7071

Cited by 2 publications

(2 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Từ năm 2018 trở lại đây, Việt Nam đã có một số nghiên cứu về hệ gen ty thể trên các cá thể thuộc cộng đồng dân tộc người Việt Nam. Các nghiên cứu này chủ yếu tập trung vào việc so sánh khác biệt giữa các dân tộc thuộc các nhóm ngữ hệ với nhau [10][11][12]. Nhằm nghiên cứu đa dạng di truyền và phân bố các nhóm đơn bội trong cùng ngữ hệ, chúng tôi đã phân tích toàn bộ hệ gen ty thể của 108 cá thể thuộc ba dân tộc Tày, Thái, Nùng trong ngữ hệ Tai -Kadai, từ đó so sánh đánh giá mức độ đa dạng quần thể và phân bố nhóm đơn bội của các dân tộc này với các quần thể người khác trong cùng khu vực lân cận.…”

Section: Mở đầU *unclassified

Genetic Diversity and Haplogroup Distribution of Three Ethnic Groups Tay, Thai, and Nung

Duong,

Anh,

Hai

2024

NST

View full text Add to dashboard Cite

The mitochondrial genome, with outstanding characteristics such as maternal inheritance, non-recombination and high mutation rate, is of great importance in population genetics and evolution research. To study the genetic diversity and the distribution of haplogroups of the Tai – Kadai language group, blood samples of 108 men from three ethnic groups Tay, Thai and Nung were collected. Total DNA extracted from blood samples was used for library preparation and whole mitochondrial genome sequencing using NGS. Comparing the obtained mitochondrial genome sequence with the RSRS (Reconstructed Sapiens Reference sequence) from Genbank (NC_012920) revealed 3929 distinct variants in 108 individuals with 1663 variants in the Tay ethnic group, 905 variants in the Thai ethnic group and 1361 variants in the Nung ethnic group. Nucleotide diversity (π) and haplotype were highest in the Thai ethnic group, being 0.0023 and 0.989, respectively. The genetic distances between each ethnic group pair (Tay-Nung, Tay-Thai and Thai-Nung), as shown by the FST values, were 0.03101; 0.00447 and 0.03282, respectively. Haplogroup analysis showed that 108 studied individuals belonged to 33 different haplogroups, belonging to 2 groups of haplogroups M and N. The most frequent haplogroups in Tay Thai and Nung were B4, F1 and M7, respectively. The results of this study show that although belonging to the same Tai - Kadai language family, the mitochondrial genomes among the three ethnic groups Tay, Thai, and Nung still have notable differences.

show abstract

Section: Mở đầU *unclassified

Genetic Diversity and Haplogroup Distribution of Three Ethnic Groups Tay, Thai, and Nung

Duong,

Anh,

Hai

2024

NST

View full text Add to dashboard Cite

show abstract

“…In 2016, sequenced and analyzed mtDNA HV-II fragments in D-loop region of 169 healthy individuals from four ethnic groups belonging to Kinh, Muong, Ede and Jarai. 79 different haplogroups were found among these 169 individuals (Hung et al, 2016). In 2017 a research on 622 individuals from 6 ethnic groups: Kinh, Mong, Tay, Nung, Hoa, Khmer, showed a historical gene flow between these Vietnamese ethnics and other neighboring countries (Pischedda et al, 2017).…”

Section: Introductionmentioning

confidence: 95%

Study on genetic variations of the D-loop region in three Vietnamese ethnic groups Kinh, Lolo and Lahu

Dương¹,

Phong²,

Ngoc³

et al. 2020

Vietnam J. Biotechnol.

Self Cite

View full text Add to dashboard Cite

Mitochondrial DNA (mtDNA) sequence analysis has been widely used to investigate population genetic and evolutional history of different ethnic groups worldwide. In this study, the D-loop region of 119 Vietnamese individuals belonging to three different ethnic groups was sequenced and compared with reference mtDNA on rCRS for genetic variations. Total 218 genetic polymorphisms were found in this population, among which 48 variations appeared with frequencies of more than 0.1. Further statistical analysis showed that there were 23, 13 and 24 single nucleotide polymorphisms (SNP) distributed differently between Kinh vs. Lolo, Kinh vs. Lahu , and Lolo vs. Lahu groups, respectively. The mean pairwise genetic distances between each pair of ethnic groups were 0.0101, 0.0098 and 0.0092 for Kinh - Lolo, Kinh - Lahu, Lolo - Lahu, respectively. This indicated that although the Lolo and Lahu ethnic groups both belong to the Tibeto-Burman language group, the genetic distance between them was no closer than the genetic distances between them and the Kinh group of the Viet-Muong (Austroasiatic) language group. This study was the first research on the D-loop region of the Lolo and Lahu populations in Vietnam. These results provided more data for exploring the genetic background and the history of those ethnic groups as well as other minority ethnic groups in Vietnam.

show abstract

Genetic variation of mitochondrial sequence-hv2 in Vietnamese populations

Cited by 2 publications

References 22 publications

Genetic Diversity and Haplogroup Distribution of Three Ethnic Groups Tay, Thai, and Nung

Genetic Diversity and Haplogroup Distribution of Three Ethnic Groups Tay, Thai, and Nung

Study on genetic variations of the D-loop region in three Vietnamese ethnic groups Kinh, Lolo and Lahu

Contact Info

Product

Resources

About