Genetic variation of innate immune response genes in invasive pneumococcal and meningococcal disease applied to the pathogenesis of meningitis

Sanders, Marieke S.; Well, Gijs Th. J. van; Ouburg, Sander; Morré, Servaas A.; Furth, A. Marceline van

doi:10.1038/gene.2011.20

Cited by 30 publications

(33 citation statements)

References 132 publications

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“…The disease evolution is mainly influenced by the host immune response determined by several genes that regulate the intensity of the inflammatory response to infection [8][9][10][11]. In previous work, we obtained data showing association of the SNPs APEX1Asn148Glu, OGG1 Ser326Cys, and PARP-1 Val762Ala with BM.…”

Section: Discussionmentioning

confidence: 98%

“…Their deficiency may cause predisposition to diseases but in excess or in the wrong tissues can cause serious complications as observed in BM [8][9][10][11]. Some BER enzymes as APEX1, OGG1 and PARP-1 were implicated in the regulation of expression of some cytokines [6].…”

Section: Discussionmentioning

confidence: 99%

“…In this step, the immune defense system is important to combat the pathogens, avoiding the disease progression [8,9]. Thus, deficiency in the innate or acquired immune response may cause predisposition to disease [10,11]. Furthermore, strategies have been developed along the evolutionary process to enable some of these pathogens to overcome this natural barrier.…”

Section: Introductionmentioning

confidence: 99%

“…Genetic factors, such as single-nucleotide polymorphisms (SNPs) in DNA repair genes and in immune response genes have been shown to be associated with BM occurrence [11,14].…”

Section: Introductionmentioning

confidence: 99%

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Polymorphisms in DNA Repair Gene XRCC1 (Arg194Trp) and (Arg399Gln) and their Role in the susceptibility of Bacterial Meningitis

Pinheiro¹,

Fontes²,

Oliveira³

et al. 2015

J Meningitis

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Meningitis is a contagious infectious disease with high rates of mortality. Most pathogenic microbes in humans have the ability to cause bacterial meningitis. However, the most common pathogens are Streptococcus pneumoniae, Neisseria meningitidis and Haemophilus influenzae type b (Hib). It was found that the susceptibility to this infectious disease may be related to genetic characteristics of the host, such as the occurrence of single nucleotide polymorphisms (SNPs). In our previous work, association of SNPs in DNA repair genes with bacterial meningitis (BM) was demonstrated. In this study we evaluated two non-synonymous SNPs of the repair gene XRCC1 Arg194Trp (rs 1799782) and Arg399Gln (rs 25487) in patients with BM and health volunteers. The patient genotypes were investigated by PCR-RFLP. DNA damages were quantified using the genomic DNA with formamidopyrimidine DNA-glycosylase (FPG). Cytokines and chemokines were quantified from cerebrospinal fluid samples from BM patients. Concerning the SNP XRCC1 Arg194Trp, none association was found relation to BM. However, a higher frequency of heterozygous genotype for XRCC1 Arg399Gln was observed in the control group compared to the BM group (P = 0.043; OR = 0.426). DNA damage and cytokine/chemokines levels were not positively correlated with polymorphic genotypes. In conclusion, there is an indication that the SNP XRCC1 Arg399Gln could have a possible protective effect against BM.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Genetic factors, such as single-nucleotide polymorphisms (SNPs) in DNA repair genes and in immune response genes have been shown to be associated with BM occurrence [11,14].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Polymorphisms in DNA Repair Gene XRCC1 (Arg194Trp) and (Arg399Gln) and their Role in the susceptibility of Bacterial Meningitis

Pinheiro¹,

Fontes²,

Oliveira³

et al. 2015

J Meningitis

View full text Add to dashboard Cite

show abstract

“…The ability to adhere to or penetrate the mucosa, or to survive and multiply in blood or infect organs (especially the brain) are commonly-recognized virulence factors that, like epidemiology, may differ among strains, serogroups or types of encapsulated bacteria within a species (1,5,24,(28)(29)(30)(31)(32). Susceptibility to disease or asymptomatic carriage may coincide or occur in distinct population groups (Table 4).…”

Section: Kissingmentioning

confidence: 99%