Genetic Variation of Goat Interferon Regulatory Factor 3 Gene and Its Implication in Goat Evolution

Okpeku, Moses; Esmailizadeh, Ali; Adeola, Adeniyi C.; Shu, Liping; Zhang, Yesheng; Wang, Yangzi; Sanni, Timothy M.; Imumorin, Ikhide G.; Peters, Sunday O.; Zhang, Jiajin; Dong, Yang; Wang, Wen

doi:10.1371/journal.pone.0161962

Cited by 5 publications

(4 citation statements)

References 37 publications

(44 reference statements)

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“…Many of the indigenous breeds are able to tolerate harsh climates (Yakubu et al, 2010), as well as pathogen, pest and disease pressure (Okpeku et al, 2011b), which improve their resilience in the challenging and changing ecological terrains of Africa. Suitability to traditional systems, short generation interval and ability to thrive on poor quality diets (Okpeku et al, 2016a) all combine to make these indigenous livestock breeds strategic (Yakubu et al, 2010) for improved food production and productivity.…”

Section: Introductionmentioning

confidence: 99%

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A Review of Challenges to Genetic Improvement of Indigenous Livestock for Improved Food Production in Nigeria

Okpeku¹,

Ogah²,

Adeleke³

2019

AJFAND

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Indigenous livestock production is intertwined with the life style of Nigerians. The Nigerian livestock industry employs the bulk of the rural workforce , and indigenous livestock breeds are abundant in the industry. These breeds are distributed across the diverse agro-ecological production systems, and are carriers of unique and responsive genotypes shaped by the needs of their managers. Despite their unique features, most indigenous livestock breeds are characteristically low in production and productivity. Improvement of these breeds represents a logical starting point for improving food security and agricultural productivity in Nigeria. To better understand natural genetic variation in these indigenous livestock breeds and strategies for improvement, better genetic characterization is required. Molecular assisted selection (MAS) will be valuable in the pursuit of selection for increased production, but the application of MAS to livestock improvement is constrained by a variety of limitations. The focus of this paper is to elucidate the potential of MAS as a tool for genetic improvement of indigenous livestock, to identify constraints and challenges in MAS implementation and propose solutions to increasing MAS feasibility in pursuit of improved food security and sustainability in Nigeria.

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Section: Introductionmentioning

confidence: 99%

“…However, very little attention has been paid to the genetic characterization and possible improvement (Awobajo et al, 2015;Okpeku et al, 2016a) of these indigenous livestock breeds. In fact, the genetic architecture of most of these animal breeds has not been documented (Okpeku et al 2016a,b).…”

Section: Introductionmentioning

confidence: 99%

A Review of Challenges to Genetic Improvement of Indigenous Livestock for Improved Food Production in Nigeria

Okpeku¹,

Ogah²,

Adeleke³

2019

AJFAND

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“…Polymorphism of the gene in the different breed reflects diversity of the gene in the populations studied. Evolutionary process and diversity of the gene [40,41] is not clear but needs to be investigated. However the present study clearly demonstrated that Nigeria Zebu cattle possess a diversity of HSP-70 ; diversity or heterosis influences evolution and adaptability.…”

Section: Resultsmentioning

confidence: 99%

qRT-PCR/High Resolution Melting Analyses detected polymorphisms of HSP-70 gene in Zebu cattle

Onasanya

Okpeku

Thiruvekander

et al. 2018

Preprint

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28Concerns over environmental heat stress have increased in recent years with the 29 realization of global warming effects on environment and subsequently on animal production. 30 Heat stress indicators help to monitor adaptability and survivability of livestock to thermal 31 assault; a consequent effect of global warming. Heat shock proteins (HSPs) are highly 32 conserved and are classified into six groups. Heat shock protein (HSP) 70 gene is a member of 33 molecular chaperone, known to be highly expressed under stressful environmental and 34 physiological conditions. In this study, we used a one-step qReal-Time PCR, followed by 35 high-resolution melting analyses (HRMA) for detection and identification of polymorphism of 2 36 HSP-70 gene in four extant cattle breeds of (White Fulani, Sokoto Gudali, Red Bororo and 37 Ambala). qRT-PCR/HRMA-based assay detected twelve (12) genetic variant groups of HSP-38 70 gene. Ambala breed of Nigerian Zebu cattle had the highest number (7) of genetic variants 39 of HSP-70 gene followed by Red Bororo breed (6 genetic variants), Sokoto Gudali breed had 40 5 genetic variants while White Fulani breed had the least (4 genetic variants) number of 41 genetic variants in the population of Nigerian Zebu cattle breeds examined. We therefore 42 hypothesize that the detected variant groups can be interrogated for their possible effects on 43 thermo-tolerance performance of zebu cattle bred under thermal assaults of tropical 44 conditions. 45 46 Introduction 47 Cattle industry is a very important sector of livestock husbandry in many developing 48 countries all over the world. Cattle serve as valuable source of animal proteins and hide, and 49 contribute in no small measure to national economy. Heat stress is a significant issue in the 50 livestock industry. 51 The impact of heat stress on livestock, particularly on cattle can be overwhelming [1], 52 resulting in reduced feed intake, reduced fertility, increased respiratory and heart rates, 53 increased peripheral blood flow and profuse sweating, reduced milk production and lower 54 milk quality [2]. These impacts according [2], can result in significant loss of income and 55 increase in management costs. Losses to the cattle industry due to heat stress was estimated at 56 about $900 million per annum [3]. The issue is more exacerbated with increased global 57 warming, as such, the impact of heat stress needs to be addressed and ameliorated to maintain 58 animal health status, adaptability, survivability and performance.59 Heat shock proteins (HSPs), are a group of proteins conserved in both prokaryotic and 60 eukaryotic organisms. The expression of HSP genes are related to thermal stress, they play 61 vital roles in cell response to environmental stress [4, 5]. Studies have shown that the 62 expression of HSP genes affects follicular development, embryonic survival and pregnancy 63 maintenance [6-8]. For this reason, the functional characterization of this gene family is 3 64 important. The HSP-70 protein, also referred to as HSP-70 ge...

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“…We further discovered a few potential loci on different chromosomes that could be important in the goat immune system. For instance, we found IL23A , IRF3, RFC2 and MITF genes that are related to immune response traits [ 54 – 57 ].…”

Section: Discussionmentioning

confidence: 99%

Genomic analysis uncovers novel candidate genes related to adaptation to tropical climates and milk production traits in native goats

Zhang,

Asadollahpour Nanaei,

Jafarpour Negari

et al. 2024

BMC Genomics

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Background Since domestication, both evolutionary forces and human selection have played crucial roles in producing adaptive and economic traits, resulting in animal breeds that have been selected for specific climates and different breeding goals. Pakistani goat breeds have acquired genomic adaptations to their native climate conditions, such as tropical and hot climates. In this study, using next-generation sequencing data, we aimed to assess the signatures of positive selection in three native Pakistani goats, known as milk production breeds, that have been well adapted to their local climate. Results To explore the genomic relationship between studied goat populations and their population structure, whole genome sequence data from native goat populations in Pakistan (n = 26) was merged with available worldwide goat genomic data (n = 184), resulting in a total dataset of 210 individuals. The results showed a high genetic correlation between Pakistani goats and samples from North-East Asia. Across all populations analyzed, a higher linkage disequilibrium (LD) level (– 0.59) was found in the Pakistani goat group at a genomic distance of 1 Kb. Our findings from admixture analysis (K = 5 and K = 6) showed no evidence of shared genomic ancestry between Pakistani goats and other goat populations from Asia. The results from genomic selection analysis revealed several candidate genes related to adaptation to tropical/hot climates (such as; KITLG, HSPB9, HSP70, HSPA12B, and HSPA12B) and milk production related-traits (such as IGFBP3, LPL, LEPR, TSHR, and ACACA) in Pakistani native goat breeds. Conclusions The results from this study shed light on the structural variation in the DNA of the three native Pakistani goat breeds. Several candidate genes were discovered for adaptation to tropical/hot climates, immune responses, and milk production traits. The identified genes could be exploited in goat breeding programs to select efficient breeds for tropical/hot climate regions.

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Genetic Variation of Goat Interferon Regulatory Factor 3 Gene and Its Implication in Goat Evolution

Cited by 5 publications

References 37 publications

A Review of Challenges to Genetic Improvement of Indigenous Livestock for Improved Food Production in Nigeria

A Review of Challenges to Genetic Improvement of Indigenous Livestock for Improved Food Production in Nigeria

qRT-PCR/High Resolution Melting Analyses detected polymorphisms of HSP-70 gene in Zebu cattle

Genomic analysis uncovers novel candidate genes related to adaptation to tropical climates and milk production traits in native goats

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