Genetic variation of chickenMC1Rgene in different plumage colour populations

Guo, Xiuli; Li, X L; Li, Y; Gu, Zi-lin; Zheng, Chang-Shan; Wei, Zhonghua; Wang, J S; Zhou, Rongyan; Li, L H; Zheng, Huaiping

doi:10.1080/00071668.2010.518408

Cited by 33 publications

(31 citation statements)

References 14 publications

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“…Therefore, it is suggested that, at least in ducks, the two missense SNPs, c.52A＞G and c.376 A＞G (p.Lys18Glu and p.Ile126Val respectively), may have a major effect on the extended black phenotypes. Additionally, the p.Val126Ile substitution in the third transmembrane domain of MC1R is associated with plumage pigmentation in chicken and duck (Kerje et al, 2003;Guo et al, 2010;Yu et al, 2012;Oh et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Identification of MC1R SNPs and their Association with Plumage Colors in Asian Duck

et al. 2017

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The melanocortin 1 receptor (MC1R) gene is a candidate functional gene that controls the pigment production in melanocytes. The aim of this study was to identify polymorphisms and investigate the effect of the MC1R gene on plumage coloration in duck breeds, including Korean native ducks. Initially, 34 individuals from seven duck breeds were sequenced, obtaining 12 polymorphisms. Five single nucleotide polymorphisms (SNPs) in the coding region were non-synonymous, with mutations corresponding to amino acid changes. Among these, four SNPs were genotyped using polymerase chain reaction-restriction fragment length polymorphism method in 264 individuals from same seven duck breeds. Fisher's exact test was conducted to identify possible relationships between the MC1R gene polymorphisms and plumage color variations. Four non-synonymous SNPs, c.52A＞G (p.Lys18Glu), and c.376 A＞ G (p.Ile126Val), c.409G＞A (p.Ala137Thr) and c.649C＞T (p.Arg217Cys), were associated with the two deduced genotypes (i.e., E/E and e+ /e+) based on plumage color phenotypes. In addition, we reconstructed MC1R gene haplotypes, where the haplotype AAGC showed its highest frequency in Nageswari duck breed, which presents an extended black phenotype. Our results indicate that the identified polymorphisms by this study can be used to explore associations with plumage color variations in Asian duck breeds.

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Section: Discussionmentioning

confidence: 99%

Identification of MC1R SNPs and their Association with Plumage Colors in Asian Duck

et al. 2017

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“…A retroviral insertion in the TYR (tyrosinase) gene is associated with a recessive white mutation in chickens [10]. MC1R genes play a role in the rich diversity of plumage colour in chickens [12, 13]. Avian plumage colour is a complex trait involving major functional genes.…”

Section: Introductionmentioning

confidence: 99%

Transcriptome Profile Analysis of Mechanisms of Black and White Plumage Determination in Black-Bone Chicken

Wang

Liao

et al. 2018

Cell Physiol Biochem

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Background/Aims: Melanin is a major and ubiquitous component of plumage colouration, and patterns of melanin pigmentation in birds are extremely varied. However, the molecular mechanism of pigmentation in avian plumage is still largely unknown. Methods: To elucidate the molecular mechanisms involved in the formation of black and white plumage, this study takes advantage of high-throughput sequencing technology to compare differences in the transcriptome between black and white chicken feather bulbs. In total, we constructed six cDNA libraries from black (Group B) and white (Group W) feather bulbs in the dorsal plumage of Muchuan black-boned chickens. Results: A comparison between Groups B and W revealed 61 differentially expressed genes, with 47 displaying higher, and 14 displaying lower, levels of expression in white feather bulbs. Our results revealed a set of candidate genes and two potential metabolic pathways involved in black-bone chicken plumage melanogenesis. These include four homeobox genes (HOXB9, HOXC8, HOXA9, and HOXC 9), two glutathione (GSH) metabolism-related genes (CHAC1 and GPX3), and the transforming growth factor beta (TGF-β) signalling pathway. Two known genes, TYR and MITF, were also shown to play a role in melanin formation. Conclusion: our data provide a valuable resource for discovering genes important in plumage melanin formation and will help further elucidate the molecular mechanisms for black and white plumage.

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“…The highly significant nonsynonymous mutations (Met71Thr, Glu92Lys, Ala126Ile, Thr143Ala, Cys213Arg and His215Pro) were associated with eumelanin and pheomelanin in chicken plumage colors (Guo et al, 2010;Kerje et al, 2003). Study in chicken breed discrimination has extended exiting knowledge on plumage color controlled by the MC1R gene locus might be a candidate marker.…”

Section: Mc1r Genementioning

confidence: 99%

“…The LEI0258 allele sizes with those repeat and polymorphic structure shared among several distinct B haplotypes which completely sequence the LEI0258 locus in Korean native chicken compared with genetic resources (Table 2). Nonsynonymous Kerje et al, 2003;Guo et al, 2010;Tixier-Biochard, 2011 These sequence data revealed distinguishing SNP differences for some of these haplotypes. Despite the many generation of separation, the allelic identity is carried by the sequence information.…”

Section: Lei0258 Markermentioning

confidence: 99%

“…The MC1R gene sequence data were identified 34 polymorphic sites on synonymous, nosynonymous and indel (insertion/deletion) mutations, which were previously reported (Guo et al, 2010;Kerje et al, 2003; Tixier-Biochard, 2011) ( Table 3). The highly significant nonsynonymous mutations (Met71Thr, Glu92Lys, Ala126Ile, Thr143Ala, Cys213Arg and His215Pro) were associated with eumelanin and pheomelanin in chicken plumage colors (Guo et al, 2010;Kerje et al, 2003).…”

Section: Mc1r Genementioning

confidence: 99%

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DNA markers in chicken for breed discrimination

Hoque¹,

Lee²,

Lee

2012

CNU Journal of Agricultural Science

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:There is an emerging interest in using DNA markers for breed identification in animals. This article reviews the breed identification markers in chicken, mainly developed in Chungnam National University, with particular emphasis on the mitochondrial DNA markers and the nuclear DNA markers including the SNPs in MHC region and the plumage color related MC1R markers. This information would be very useful for an appropriate conservation breeding program as well as for the establishment of molecular markers for chicken breed identifications.

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Genetic variation of chickenMC1Rgene in different plumage colour populations

Cited by 33 publications

References 14 publications

Identification of <i>MC1R </i>SNPs and their Association with Plumage Colors in Asian Duck

Identification of <i>MC1R </i>SNPs and their Association with Plumage Colors in Asian Duck

Transcriptome Profile Analysis of Mechanisms of Black and White Plumage Determination in Black-Bone Chicken

DNA markers in chicken for breed discrimination

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