Genetic variation influences immune responses in sensitive rats following exposure to TiO2 nanoparticles

Gustafsson, Åsa; Jonasson, Sofia; Sandström, Thomas; Lorentzen, Johnny C.; Bucht, Anders

doi:10.1016/j.tox.2014.10.004

Cited by 27 publications

(20 citation statements)

References 56 publications

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“…ROS, which are produced by many known activators of NLRP3 inflammasomes, trigger NLRP3 inflammasome formation and activation in response to many exogenous stimuli as well as endogenously produced molecules or factors secreted by damaged cells, such as damage-associated molecular patterns (DAMPs) 3940. In this study, ROS levels tended to be increased in the lungs of mice exposed to TiO 2 NPs, OVA-sensitized/challenged, and OVA-sensitized/challenged-plus-TiO 2 NP-exposed mice.…”

Section: Discussionmentioning

confidence: 99%

Effect of TiO₂Nanoparticles on Inflammasome-Mediated Airway Inflammation and Responsiveness

Kim

Lee

et al. 2017

Allergy Asthma Immunol Res

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PurposeNanoparticles (NPs) may cause cell and tissue damage, leading to local and systemic inflammatory responses and adverse effects on health due to the inhalation of particulate matter. The inflammasome is a major regulator of inflammation through its activation of pro-caspase-1, which cleaves pro-interleukin-1β (pro-IL-1β) into its mature form and may induce acute and chronic immune responses to NPs. However, little is known about the response of the inflammasome to NP exposure via the airways in asthma. The aim of this study was to identify the impact of titanium dioxide (TiO2) NPs on inflammasome in a mouse model of allergic asthma.MethodsMice were treated with ovalbumin (OVA) or TiO2 NPs. IL-1β, IL-18, NAIP, CIITA, HET-E, TP-2 (NACHT), leucine-rich repeat (LRR), pyrin domain-containing protein 3 (NLRP3), and caspase-1 were assessed by Western blotting. Caspase-1 was assessed by immunohistochemistry (IHC). Levels of reactive oxygen species (ROS)—as markers of oxidative damage—and the mediators 8-isoprostane and carbonyl were measured by enzyme-linked immunosorbent assay (ELISA).ResultsAirway hyperresponsiveness (AHR) and inflammation were increased in OVA-sensitized/challenged mice, and these responses were exacerbated by exposure to TiO2 NPs. NP treatment increased IL-1β and IL-18 expression in OVA-sensitized/challenged mice. NPs augmented the expression of NLRP3 and caspase-1, leading to production of active caspase-1 in the lung. Caspase-1 expression was increased and exacerbated by TiO2 NP exposure in OVA-sensitized/challenged mice. ROS levels tended to be increased in OVA-sensitized/challenged and OVA-sensitized/challenged-plus-TiO2 NP-exposed mice.ConclusionsOur data demonstrated that inflammasome activation occured in asthmatic lungs following NP exposure, suggesting that targeting the inflammasome may assist in controling NP-induced airway inflammation and hyperresponsiveness.

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Section: Discussionmentioning

confidence: 99%

Effect of TiO₂Nanoparticles on Inflammasome-Mediated Airway Inflammation and Responsiveness

Kim

Lee

et al. 2017

Allergy Asthma Immunol Res

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“…TiO 2 NPs also increase levels of caspase-1 and activate the NLRP3 inflammasome to generate increased production of pro-inflammatory IL-1β, likely through reactive oxygen species (ROS) production [16]. Genetic susceptibility has also been shown to affect the immune response in the OVA model; Gustafsson et al found differences in TiO 2 -induced inflammation in two susceptible rat strains, with both showing exacerbated IgE production and neutrophilia [19]. A study by Hussain et al utilizing a toluene diisocyanate (TDI) mouse model of asthma similarly found that TiO 2 NPs significantly increased lung inflammation; however, AHR was not increased [21].…”

Section: Enm-induced Asthma Exacerbationsmentioning

confidence: 99%

The Toxicology of Engineered Nanomaterials in Asthma

Ihrie

Bonner

2018

Curr Envir Health Rpt

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Recent studies highlight the ability of metal nanoparticles (NPs) and carbon nanotubes (CNTs) to not only exacerbate pre-existing asthma in animal models but also initiate allergic airway disease directly. CNTs alone are shown to cause airway mucus production, elevated serum IgE levels, and increased T2 cytokine levels, all key indicators of asthma. The ability of ENMs to modulate the immune response in asthma varies depending on their physicochemical properties and exposure timing. CNTs consistently exacerbate asthma, as do Ni and TiO NPs, whereas some NPs like Au attenuate asthma. Evidence is strong that ENMs can contribute to allergic airway disease; however, more work is required to determine their mechanisms, and more epidemiological studies are needed to validate results from animal models.

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“…Using nano-grade materials as additions is the latest approach and is an effective way to cover flaws on face and other parts of the body. However, this modern technology has had doubts about its safety for human health within last decade [1]. Even though cosmetic products are supervised strictly by the World Health Organization, it is still worrisome since they are interrelated closely in life.…”

Section: Introductionmentioning

confidence: 99%

Thermal analysis on potential risk of cosmetic materials by DSC

Chen

Huang

et al. 2018

MATEC Web Conf.

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Abstract.To explore the potential risk of usage on daily chemicals, the product which most contact for human directly, cosmetics, were selected as study object. In this study, common cosmetic materials, such as propylene glycol, ethanolamine, silicon dioxide, iron oxide, and copper oxide were discussed for potential hazard. According to results of differential scanning calorimetry experiments, the apparent activation energy and SADT were calculated out as 779.22 kJ mol −1 and 45°C, respectively.

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Genetic variation influences immune responses in sensitive rats following exposure to TiO2 nanoparticles

Cited by 27 publications

References 56 publications

Effect of TiO₂Nanoparticles on Inflammasome-Mediated Airway Inflammation and Responsiveness

Effect of TiO₂Nanoparticles on Inflammasome-Mediated Airway Inflammation and Responsiveness

The Toxicology of Engineered Nanomaterials in Asthma

Thermal analysis on potential risk of cosmetic materials by DSC

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Genetic variation influences immune responses in sensitive rats following exposure to TiO2 nanoparticles

Cited by 27 publications

References 56 publications

Effect of TiO2Nanoparticles on Inflammasome-Mediated Airway Inflammation and Responsiveness

Effect of TiO2Nanoparticles on Inflammasome-Mediated Airway Inflammation and Responsiveness

The Toxicology of Engineered Nanomaterials in Asthma

Thermal analysis on potential risk of cosmetic materials by DSC

Contact Info

Product

Resources

About

Effect of TiO₂Nanoparticles on Inflammasome-Mediated Airway Inflammation and Responsiveness

Effect of TiO₂Nanoparticles on Inflammasome-Mediated Airway Inflammation and Responsiveness