Genetic variation in the tumor necrosis factor-? promoter region and in the stress protein hsp70-2

Mestiri, Souhir; Bouaouina, Noureddine; Ahmed, Slim Ben; Khedhaier, Achraf; Jrad, Besma Bel Hadj; Remadi, Sami; Chouchane, D.S.C. Lotfi

doi:10.1002/1097-0142(20010215)91:4<672::aid-cncr1050>3.0.co;2-j

Cited by 108 publications

(79 citation statements)

References 28 publications

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“…HspA1B allele G might be associated with TNF2 allele (Chouchane et al 1997;Mestiri et al 2001;Galley and Lowe 2003), resulting in higher TNF response after inflammatory stimuli. This pronounced inflammatory response might result in higher level of tissue injury, resulting in the release of sHsp70.…”

Section: Discussionmentioning

confidence: 99%

Interaction of serum 70-kDa heat shock protein levels and HspA1B (+1267) gene polymorphism with disease severity in patients with chronic heart failure

Gombos

Förhécz

Pozsonyi

et al. 2008

Cell Stress and Chaperones

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Background Circulating heat shock protein 70 (Hsp70) is present in the circulation of healthy individuals and in patients with various disorders, including chronic heart failure (CHF). However, the source and routes of release of Hsp70 is only partially characterised in clinical samples. Aims The purpose of this study was to study the clinical and biological correlates of Hsp70 in a CHF population and, for the first time, to investigate the association of HspA1B (also known as Hsp70-2) +1267 alleles with serum Hsp70 levels. Methods A total of 167 patients (123 men, 44 women) with <45% left ventricular ejection fraction (LVEF) were enrolled; serum Hsp70 level was determined by enzymelinked immunosorbent assay and HspA1B +1267 polymorphism by polymerase chain reaction-restriction fragment length polymorphism.

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Section: Discussionmentioning

confidence: 99%

Interaction of serum 70-kDa heat shock protein levels and HspA1B (+1267) gene polymorphism with disease severity in patients with chronic heart failure

Gombos

Förhécz

Pozsonyi

et al. 2008

Cell Stress and Chaperones

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“…It was shown that TNF alpha -308 A/A genotype may play an important role in the tumorigenesis of breast carcinoma (Mestiri et al, 2001). Azmy and coworkers (2004) demonstrated no association between the -308 and -238 TNF alpha polymorphism and susceptibility to breast cancer in a North European population.…”

Section: Discussionmentioning

confidence: 99%

TNF alpha promoter polymorphisms analysis in benign and malignant breast lesions

Sirotković-Skerlev¹,

Čačev

Križanac

et al. 2007

Experimental and Molecular Pathology

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“…Individuals with the TNF2 homozygous genotype demonstrate an increased predisposition to breast cancer (RR, 4.44; P=0.006). In addition, the TNF2 homozygous genotype appears to be an independent prognostic indicator for both disease free survival and overall survival (Mestiri et al, 2001). However, this polymorphism does not influence colorectal cancer risk or severity (Park et al, 1998).…”

Section: Tumour Necrosis Factormentioning

confidence: 99%

Role of genetic polymorphisms in tumour angiogenesis

2002

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Angiogenesis plays a crucial role in the development, growth and spread of solid tumours. Pro-and anti-angiogenic factors are abnormally expressed in tumours, influencing tumour angiogenesis, growth and progression. Polymorphisms in genes encoding angiogenic factors or their receptors may alter protein expression and/or activity. This article reviews the literature to determine the possible role of angiogenesis-related polymorphisms in cancer. Further research studies in this potentially crucial area of tumour biology are proposed.

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Genetic variation in the tumor necrosis factor-? promoter region and in the stress protein hsp70-2

Cited by 108 publications

References 28 publications

Interaction of serum 70-kDa heat shock protein levels and HspA1B (+1267) gene polymorphism with disease severity in patients with chronic heart failure

Interaction of serum 70-kDa heat shock protein levels and HspA1B (+1267) gene polymorphism with disease severity in patients with chronic heart failure

TNF alpha promoter polymorphisms analysis in benign and malignant breast lesions

Role of genetic polymorphisms in tumour angiogenesis

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