Genetic variation in the TP63 gene is associated with lung cancer risk in the Han population

Abstract

Lung cancer is one of the most common malignant tumors that seriously threaten human health. Current evidence suggests that heredity contributes to the progression of lung cancer. To investigate and validate potential genetic associations with the risk of lung cancer, we conducted a case-control study including 309 cases and 310 controls from Xi'an City, which is located in northwest China, and genotyped six SNPs in five genes, which are related to metabolic process. Overall, our results show that the SNP rs10937405 was associated with a decreased occurrence of lung cancer (OR = 0.72; 95% CI = 0.56-0.92; p = 0.009). In the genetic models analysis, we found that genotype "CT" of rs10937405 in TP63 was associated with a decreased lung cancer risk (OR = 0.71; 95% CI, 0.51-0.99; p = 0.031); the genotype "TT" of rs10937405 showed a decreased lung cancer risk in the co-dominant model (OR = 0.53; 95% CI, 0.30-0.95; p = 0.031). The genotype "CT-TT" of rs10937405 also showed a decreased lung cancer risk in the dominant model (OR = 0.67; 95% CI, 0.49-0.92; p = 0.014) and the log-additive model (OR = 0.72; 95% CI, 0.56-0.92; p = 0.0085). The genotype "CC-CT" of rs10937405 confers a higher risk of lung cancer for males than females. Our results, combined with those from previous studies, suggest that genetic variation in TP63 may influence lung cancer susceptibility in the Han population.

A Functional Polymorphism in CSF1R Gene Is a Novel Susceptibility Marker for Lung Cancer among Never-Smoking Females

“…TP63 plays important roles in cell cycle arrest and apoptosis, and also transactivates TP53 target genes. 18,[42][43][44] In the present study, TP63 rs7631358G>A was associated with an increased risk of lung cancer, mostly adenocarcinoma, among female never-smokers. 40,41 Recently, TP63 rs10937405 was identified and replicated as a susceptibility locus for lung adenocarcinoma.…”

Potential role of TP63 in apical periodontitis development

“…Mutations in the TP63 gene have been associated with human developmental diseases and skin abnormalities (Li & Xiao , Soares & Zhou ), as well as with different cancer types, such as lung, breast, bladder and squamous cell carcinoma (Hu et al . , Zhang et al . , Asgari et al .…”

“…TP63 is expressed in the nuclei of epithelial cells from several organs, such as, skin, oesophagus, exocervix, tonsil and bladder, as well as to basal cells from glandular structures, such as prostate, breast and bronchi (Di Como et al 2002). Mutations in the TP63 gene have been associated with human developmental diseases and skin abnormalities (Li & Xiao 2014, Soares & Zhou 2017, as well as with different cancer types, such as lung, breast, bladder and squamous cell carcinoma (Hu et al 2014, Zhang et al 2014, Asgari et al 2016.…”

Genetic analysis of pharmacogenomic VIP variants in the Blang population from Yunnan Province of China

“…Although rs1540339 has not been found to be relevant in the Blang, it is noteworthy in future studies. At present, there are more teams, including Jin TB et al, devoted to disease research of SNPs (Du et al, ; Duan et al, ; Hu et al, ; Wang et al, ; Yang et al, ), and we hope that our data will complement the pharmacogenomics database and provide some help for the development of personalized medicine.…”