“…The RAS has been the target of active research interest since the discovery of renin more than 100 years ago (Tigerstedt R & PG., 1898), reflecting its importance in the pathogenesis of hypertension and other cardiovascular diseases (Ellis, et al, 2012; Hsueh & Wyne, 2011; Re, 2004; Te Riet, van Esch, Roks, van den Meiracker, & Danser, 2015; Vijayaraghavan & Deedwania, 2011). In the traditional view of the systemic RAS, active renin is generated by the removal of a prosegment from prorenin, a precursor of renin, in the juxtaglomerular cells of the kidney.…”