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REPORT DATE
06-02-20082. REPORT TYPE
SPONSOR/MONITOR'S REPORT NUMBER(S)
DISTRIBUTION / AVAILABILITY STATEMENTApproved for Public Release; Distribution Unlimited
SUPPLEMENTARY NOTES
ABSTRACTThe P582S C->T and A588T G->A polymorphisms in the Hypoxia-inducible factor-1α (HIF-1α) gene have been associated with enhanced stability of the protein and androgen-independent prostate cancer (CaP) During the course of our research we published that P582S polymorphism was not associated with CaP (see appendix). However we observed a significant interaction of the P582S genotype with insulin-like growth factor binding protein (IGFBP)-3 in modifying CaP risk such that higher IGFBP-3 levels (>= versus