Genetic Variation in the HN and SH Genes of Mumps Viruses: A Comparison of Strains from Mumps Cases with and without Neurological Symptoms

Cui, Ai‐Li; Brown, David; Xu, Wenbo

doi:10.1371/journal.pone.0061791

Cited by 16 publications

(20 citation statements)

References 43 publications

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“…Accordingly, the Urabe AM9's use as a vaccine strain was discontinued in Japan, Canada, and the United Kingdom. [19] Based on these facts, it seems that the mumps vaccine strain may need an alteration in Iran to achieve better immunization after vaccination. Previous studies have indicated that amino acid substitutions at positions 335, 354, 356, 360, 464, and 466 in the HN region, and in positions 29 and 48 in the SH region, resulted in neuro-virulence of the virus.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have indicated that amino acid substitutions at positions 335, 354, 356, 360, 464, and 466 in the HN region, and in positions 29 and 48 in the SH region, resulted in neuro-virulence of the virus. [19,42,43] The HN region is the main immunogenic part of the mumps genome and contains glycosylation sites in 3 epitope domains (aa265-288, aa329-340, aa352-360). [19] The SH region is the most variable part of the genome and is used for genotyping as well as for phylogenetic analysis of the virus.…”

Section: Discussionmentioning

confidence: 99%

“…[19,42,43] The HN region is the main immunogenic part of the mumps genome and contains glycosylation sites in 3 epitope domains (aa265-288, aa329-340, aa352-360). [19] The SH region is the most variable part of the genome and is used for genotyping as well as for phylogenetic analysis of the virus. [44,45] In this study, about 316 nucleotides of the SH and the first 162 nucleotides of the intravirion and transmembrane domains of the HN gene were sequenced.…”

Section: Discussionmentioning

confidence: 99%

“…[18] However, Urabe Am9 was later rejected because it was seen to cause postvaccination meningitis. [18,19] Several studies revealed that the occurrence of mutations, specifically in the HN and SH regions (including in antigenic and immunogenic epitopes), transformed the vaccine strain into its wild type, and may have led to the development of postvaccination meningitis. [20] The other large family of viruses that causes aseptic meningitis is the herpes virus.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Three cases of mumps virus and enterovirus coinfection in children with enteroviral meningitis

Rasti¹,

Makvandi²,

Neisi³

et al. 2016

Medicine

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Several viruses are responsible for aseptic meningitis; however, in the region of Southwest Iran, the role played by each virus is still not very well known. The aim of this study is to determine the relative frequencies of mumps virus, herpes viruses, and enteroviruses, as well as coinfections among them, in patients with aseptic meningitis.In this cross-sectional study, samples of cerebrospinal fluid were collected between December 2012 and December 2013 from patients under 14 years, who were hospitalized in Abuzar Children's Hospital in Ahvaz, Southwest Iran (the only children's hospital in Khuzestan province and Southwest Iran).All 66 cerebrospinal fluid samples and corresponding clinical data were collected from patients with aseptic meningitis by specialists, and with the patients’ consent. The DNA and RNA were extracted from these samples and subjected to polymerase chain reaction as well as reverse transcription polymerase chain reaction (RT-PCR) for detection of mumps virus, herpes viruses, and enteroviruses. Nine of the samples (3 mumps-positive and 6 enterovirus-positive) were sequenced. The mumps virus sequences were investigated for possible mutations in the SH and partial HN regions.Up to 39 patients (59.09%) were found to be positive for enteroviruses, 3 (4.5%) for mumps virus, and 1 (1.5%) for herpes viruses (specifically, the varicella-zoster virus). Two patients (3.03%) had a mumps virus and enterovirus coinfection. Among the 3 detected mumps virus samples, 1 belonged to genotype B, while the others belonged to genotype N. Six sequenced enteroviruses indicated the highest similarity with Echovirus 30. An amino acid substitution at position 51 (N→T) was detected in the HN region of genotype N mumps virus samples, in comparison to the reference strain.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Three cases of mumps virus and enterovirus coinfection in children with enteroviral meningitis

Rasti¹,

Makvandi²,

Neisi³

et al. 2016

Medicine

View full text Add to dashboard Cite

show abstract

“…However, there was no association of certain polymorphisms in the NH and the SH gene with the development of this side effect [20]. …”

Section: Vaccination Against the Muvmentioning

confidence: 99%

Mumps in the Vaccination Age: Global Epidemiology and the Situation in Germany

Beleni

Borgmann

2018

IJERPH

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Vaccination against mumps virus (MuV) (mostly measles-mumps-rubella) is routinely performed in more than 120 countries and has resulted in a distinct decrease of mumps incidence. However, alteration of mumps epidemiology has been observed in several countries after implementation of the vaccine but is sparsely documented. Moreover, outbreaks have occurred after starting vaccination, even in highly vaccinated populations. In the former German Democratic Republic (DDR) mumps was a notifiable disease but vaccination against mumps was not implemented. In the five eastern German states forming the DDR until 1990, mumps was not notifiable until 2001. Except for the lack of reporting between 1990–2000, data from Eastern Germany allow analysis of mumps epidemiology after initiating the vaccination campaign. For the period from 2001 to 2016 the data show that the incidence of mumps dropped notably after initiating vaccines, and was accompanied by an increase of the median age of patients with mumps. In Eastern Germany, no outbreaks were noted, while several outbreaks occurred in Western Germany, possibly due to a lower vaccination rate. Further literature analysis revealed that outbreaks were facilitated by waning immunity and crowding. Nevertheless, although vaccination prevented infection, the course of illness, once infected, was sometimes more complicated. In comparison to non-vaccinated populations, high rates of complicated courses occurred and were marked by orchitis, due to higher age of mumps patients. Therefore, refusing vaccination against mumps increases the risk of severe courses when living in a vaccinated population.

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Genetic characteristics of mumps viruses isolated in Korea from 2007 to 2012

Kim

Yang

et al. 2016

Journal of Medical Virology

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Mumps is a vaccine-preventable viral disease. Despite vaccine coverage of >95%, the incidence of mumps has increased in Korea since 2007. This study aimed to genetically characterize mumps virus (MuV) strains that circulated in Korea between 2007 and 2012 to determine the factors underlying mumps outbreaks. MuV was isolated from 175 clinical specimens between 2007 and 2012 in Korea. Upon analysis of the SH gene in Korean mumps virus isolates, three different genotypes were identified: I, H, and F. The MuV genotypes I and H co-circulated in Korea, and eight isolates of Korean genotype F were found within the same time period in 2008. An analysis of HN amino-acid sequence data showed that Korean isolates had no changes in their glycosylation sites. At putative neutralizing epitope sites, the Jeryl-Lynn strain showed 4-5 different amino acid sequences from those observed in Korean isolates. Korean isolates of genotypes I and H shared distinctive point mutations on putative neutralizing epitope positions in each genotype. This report describes the genetic characteristics of MuV strains circulating in Korea and provides information on endemic mumps infections. This information may be important to help prevent mumps and control outbreaks of mumps in Korea. J. Med. Virol. 88:1479-1486, 2016. © 2016 Wiley Periodicals, Inc.

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Genetic Variation in the HN and SH Genes of Mumps Viruses: A Comparison of Strains from Mumps Cases with and without Neurological Symptoms

Cited by 16 publications

References 43 publications

Three cases of mumps virus and enterovirus coinfection in children with enteroviral meningitis

Three cases of mumps virus and enterovirus coinfection in children with enteroviral meningitis

Mumps in the Vaccination Age: Global Epidemiology and the Situation in Germany

Genetic characteristics of mumps viruses isolated in Korea from 2007 to 2012

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