Genetic variation in renin predicts the effects of thiazide diuretics

Huang, Chin Chou; Chung, Chia Min; Hung, Shuen Iu; Leu, Hsin Bang; Wu, Tao Cheng; Huang, Po Hsun; Lin, Shing Jong; Pan, Wen Harn; Chen, Jaw Wen

doi:10.1111/j.1365-2362.2011.02472.x

Cited by 13 publications

(10 citation statements)

References 39 publications

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“…The findings were in accordance with our previous findings that patients with systolic hypertension respond better to thiazide treatment than those with diastolic hypertension and lower SBP [27]. Furthermore, patients with a lower baseline renin level are associated with greater BP reduction [28], which is also compatible with the notion that patients with relatively increased arteriolar resistance and volume accumulation may have a unique response to short-term thiazide treatment.…”

Section: Discussionsupporting

confidence: 92%

Hypertension subtypes modify metabolic response to thiazide diuretics

Huang

Leu

Huang

et al. 2015

Eur J Clin Investigation

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Section: Discussionsupporting

confidence: 92%

Hypertension subtypes modify metabolic response to thiazide diuretics

Huang

Leu

Huang

et al. 2015

Eur J Clin Investigation

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“…This study also replicated the greater DBP response in C allele homozygotes in the small but independent cohort. An additional variant of REN, rs11240688, was associated with HCTZ-induced BP reduction 45 . It remains to be understood whether these results can be extrapolated to populations without Asian ancestry.…”

Section: Candidate Pharmacodynamic Polymorphisms Of the Renin-angiotementioning

confidence: 99%

A Physiologic Approach to the Pharmacogenomics of Hypertension

Eadon

Chapman

2016

Advances in Chronic Kidney Disease

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“…Another study in 1447 hypertensive Chinese patients demonstrated that patients with the minor allele (A) of the AGT rs7079 SNP had a better blood pressure response to ACE inhibitors (benazepril) when compared to ACE users with the common allele (Su et al, 2007). Another group recently reported no difference in blood pressure response to hydrochlorothiazide associated with rs7079 (Huang et al, 2011). In sum, these studies suggest that variations in the AGT gene may have an influence on blood pressure response to antihypertensive therapies.…”

Section: Discussionmentioning

confidence: 99%

The effects of angiotensinogen gene polymorphisms on cardiovascular disease outcomes during antihypertensive treatment in the GenHAT study

Irvin²,

Lynch³

et al. 2014

Front. Pharmacol.

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Previous studies have reported that risk of cardiovascular morbidity and mortality substantially increases in hypertensive patients, especially among those with inadequate blood pressure control. Two common antihypertensive drug classes including thiazide diuretics and angiotensin-converting enzyme (ACE) inhibitors affect different enzymes in the renin-angiotensin-aldosterone system (RAAS). In the RAAS, angiotensinogen is converted into angiotensin II which increases blood pressure through vasoconstriction. Using a case-only design with 3448 high-risk hypertensive individuals from the Genetics of Hypertension Associated Treatment (GenHAT) study, we examined whether seven single nucleotide polymorphisms (SNPs) in the angiotensinogen gene (AGT) interact with three classes of antihypertensive drugs including chlorthalidone (a thiazide diuretic), lisinopril (an ACE inhibitor), and amlodipine (a calcium channel blocker) to modify the risk of incident coronary heart disease (CHD) and heart failure (HF) among Caucasian and African American participants, separately. We found no gene by treatment interactions to be statistically significant after correction for multiple testing. However, some suggestive results were found. African American participants with the minor allele of rs11122576 had over two-fold higher risk of CHD when using chlorthalidone compared to using amlodipine, or lisinopril compared to amlodipine (p = 0.006 and p = 0.01, respectively). Other marginal associations are also reported among both race groups. The findings reported here suggest that rs11122576 could contribute to future personalization of antihypertensive treatment among African Americans though more studies are needed.

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Genetic variation in renin predicts the effects of thiazide diuretics

Abstract: In addition to PRA, renin rs11240688 CC polymorphism may also independently predict the effect of HCTZ.

Cited by 13 publications

References 39 publications

Hypertension subtypes modify metabolic response to thiazide diuretics

Hypertension subtypes modify metabolic response to thiazide diuretics

A Physiologic Approach to the Pharmacogenomics of Hypertension

The effects of angiotensinogen gene polymorphisms on cardiovascular disease outcomes during antihypertensive treatment in the GenHAT study

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