Genetic variation in key genes associated with statin therapy in the Azores Islands (Portugal) healthy population

Melo, Mafalda S.; Balanco, Leticia; Branco, Cláudia C.; Mota-Vieira, Luísa

doi:10.3109/03014460.2014.955056

Cited by 14 publications

(20 citation statements)

References 26 publications

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“…In this study, the allele frequency of the SLCO1B1 c.388A>G polymorphism was 74.9%. Our results were similar to Chinese hyperlipidemic patients (72.1%) and Han Chinese (73.4%) population, but lower than that of Singapore Chinese (79.5%) and Singapore Malays (87.0%) populations, and higher than that of Brazilian (32%), Hungarian (36.2%), German (36.5%), Greek (43.3%), North Indian (45.0%), Finnish (46.2%), Turkish (46.3%), Roma (54.5%), Chilean (54.7%) and Singapore Indian (57.0%) populations.…”

Section: Discussionsupporting

confidence: 79%

“…The allele frequency of SLCO1B1 c.521T>C polymorphism in hypercholesterolaemic patients in the present study (11.8%) was close to that of Singapore Malays (11%), 31 Brazilian (12%) 15 and Turkish (12.2%), 32 but higher than that of African (5.7%) 26 and Singapore Indian (6.5%) 31 populations, and lower than that of English (13.0%), 25 Singapore Chinese (13%) 31 and Chilean (13.6%) populations, 16 Han Chinese (14%), 30 and Amerindian (28.3%) populations. 26 The g.89595T>C variant allele in this study (37.2%) was similar to that of Japanese (Tokyo) (39.4%) subjects, 14 Roma (LD = 95) and Hungarian (LD=96) populations.…”

Section: Discussionsupporting

confidence: 76%

“…The allele frequency of SLCO1B1 c.521T>C polymorphism in hypercholesterolaemic patients in the present study (11.8%) was close to that of Singapore Malays (11%), Brazilian (12%) and Turkish (12.2%), but higher than that of African (5.7%) and Singapore Indian (6.5%) populations, and lower than that of English (13.0%), Singapore Chinese (13%) and Chilean (13.6%) populations, Han Chinese (14%), Brazilian (14%), Caucasian (14.8%), Mulatto (14.9%), German (15.0%), Chinese (16.2%), Greek (16.3%), Roma (17.2%), Hungarian (18.9%), Finnish (20.2%) and Amerindian (28.3%) populations . The g.89595T>C variant allele in this study (37.2%) was similar to that of Japanese (Tokyo) (39.4%) subjects, but higher than that of Indian (6.4%), Mexican (10.5%), African (10.8%), Nigeria (13.6%), Caucasian (15.4%), Kenya (15.1‐18.3%), Mulatto (18.2%), Roma (18.5%), Hungarian (19.6%), African (USA) (21.1%), Italian (22.5%) and Amerindians (26.1%) populations, and lower than that of Chinese (45.2%‐48.1%) population …”

Section: Discussionsupporting

confidence: 61%

“…Linkage disequilibrium analysis in all subjects showed that 16 and Singapore Indian (57.0%) 31 populations.…”

Section: Linkage Disequilibrium Analysis Of Slco1b1 (C388a>g C52mentioning

confidence: 91%

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Lack of association between SLCO 1B1 polymorphisms and lipid‐lowering response to simvastatin therapy in Thai hypercholesterolaemic patients

et al. 2018

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Section: Discussionsupporting

confidence: 79%

Section: Discussionsupporting

confidence: 76%

Section: Discussionsupporting

confidence: 61%

“…Linkage disequilibrium analysis in all subjects showed that 16 and Singapore Indian (57.0%) 31 populations.…”

Section: Linkage Disequilibrium Analysis Of Slco1b1 (C388a>g C52mentioning

confidence: 91%

See 2 more Smart Citations

Lack of association between SLCO 1B1 polymorphisms and lipid‐lowering response to simvastatin therapy in Thai hypercholesterolaemic patients

et al. 2018

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“…[9] In two meta-analysis and one case-control studies, an association was demonstrated between SLCO1B1 c.521T>C polymorphism and statininduced myopathy. [13][14][15] The last two population-based case-control articles in Czech and Japanese population showed no association between SLCO1B1 gene polymorphism and risk of myalgia/myopathy in these two specific population. [16,17] APOE gene APOE gene is the gene encodes Apolipoprotein E. Apo E is a basic element of triglyceride-rich lipoprotein chylomicrons and VLDL and a subclass of high-density lipoprotein cholesterol (HDL-C).…”

Section: Slco1b1 Genementioning

confidence: 99%

Clinical evidence of pharmacogenetics of statins: systematic literature review

Aldawsari

Shawaqfeh

2019

J Pharm Health Serv Res

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Objectives A systematic review was conducted to explore the clinical evidence of pharmacogenetic testing with statins in a personalised approach to minimise the incidence of adverse drug reaction (ADR), ensure better response and optimise medication adherence. Methods Systematic literature review using PubMed and EMBASE/Medline database that includes all clinically relevant pharmacogenomic studies involving statins. Key findings Twenty-four articles were evaluated for a total of 120 articles screened. The included studies were classified according to study design (two randomised controlled trial studies (RCTs), three meta-analysis studies, two interventional studies, four prospective studies, 10 case-control studies, two cross-sectional studies and one data analysis study). There were 23 different genetic polymorphisms related to statins were studied clinically with the specified outcome either LDL-lowering response or adverse drug reaction. Those genes were diverse and involve metabolic enzymes, transporters and other receptors. Conclusions Many studies suggest a strong association between clinical outcomes and certain genes relevant to statins. However, these studies were observational and only a few were randomised controlled trials (RCTs). The strength of evidence to support pharmacogenetic testing for statin is not adequate.

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APOE gene ɛ4 allele (388C‐526C) effects on serum lipids and risk of coronary artery disease in southern Chinese Hakka population

Liu

et al. 2021

Clinical Laboratory Analysis

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Objective To analyze the relationship of Apolipoprotein E (APOE) and solute carrier organic anion transporter family member 1B1 (SLCO1B1) gene polymorphisms with coronary artery disease (CAD). Methods 1,129 CAD patients and 1,014 non‐CAD controls were included in the study, and relevant information and medical records were collected. The single‐nucleotide polymorphisms (SNPs) were analyzed, including rs429358, rs7412 in APOE gene and rs2306283, rs4149056 in SLCO1B1 gene. Results The CAD patients’ average age was 66.3 ± 10.7 years, while 65.5 ± 12.0 years in controls. The frequencies of APOE allele ɛ3, ɛ4, and ɛ2 were 83.01%, 10.08%, and 6.91% respectively. There were statistically significant differences in genotype ɛ3/ɛ4 (χ2 = 8.077, p = 0.005) in CAD patients compared with the controls. The SLCO1B1 genotype *1b/*1b and haplotype *1b showed the highest frequency in the study sample. Moreover, ε4 carriers had significantly lower HDL‐C, Apo‐A1 levels than ε3 carriers among CAD patients, while ε2 carriers showed lower LDL‐C, Apo‐B level, and higher Apo‐A1/Apo‐B level than ε3 and ε4 carriers. In controls, ε2 carriers showed lower LDL‐C and Apo‐B level, higher Apo‐A1, and Apo‐A1/Apo‐B level than ε4 carriers. Logistic regression analysis showed that high LDL‐C and Apo‐B level, low HDL‐C level, smoking, and the ε4 allele were risks for the presence of CAD. Conclusions APOE ε4 allele may be associated with susceptibility to CAD in southern Chinese Hakka population. It indicated that the APOE SNPs rs429358 and rs7412 are associated with CAD, but not SNPs rs2306283 and rs4149056 of SLCO1B1 gene.

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Genetic variation in key genes associated with statin therapy in the Azores Islands (Portugal) healthy population

Cited by 14 publications

References 26 publications

Lack of association between SLCO 1B1 polymorphisms and lipid‐lowering response to simvastatin therapy in Thai hypercholesterolaemic patients

Lack of association between SLCO 1B1 polymorphisms and lipid‐lowering response to simvastatin therapy in Thai hypercholesterolaemic patients

Clinical evidence of pharmacogenetics of statins: systematic literature review

APOE gene ɛ4 allele (388C‐526C) effects on serum lipids and risk of coronary artery disease in southern Chinese Hakka population

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