Genetic variation in glutathione metabolism and DNA repair genes predicts survival of small-cell lung cancer patients

Abstract

Genetic variations in genes involved in the glutathione and DNA repair pathways are associated with SCLC survival.

Predictive value of multidrug resistance proteins, topoisomerases II and ERCC1 in small cell lung cancer: A systematic review

“…Despite the intensity of research on multidrug resistance, the evidence on the predictive value of MDR1, MRP1, MRP2 and MVP in SCLC patients is limited to 14 studies including in total 939 patients, the studies' sizes ranging from 9 to a maximum of only 248 patients each (Table 2; [6,[29][30][31][32][33][34][35][36][37][38][39][40][41]). Of these studies, only two explored the predictive value for PFS [37,39] and only four studies explored the predictive value for OS [34,[37][38][39], whereas all other studies focused merely on the predictive value for response rates to chemotherapy with either cisplatin-etoposide (EP) or cyclophosphamide-epirubicin/doxorubicin-vincristine (CEV/CAV) regimens.…”

“…Of these studies, only two explored the predictive value for PFS [37,39] and only four studies explored the predictive value for OS [34,[37][38][39], whereas all other studies focused merely on the predictive value for response rates to chemotherapy with either cisplatin-etoposide (EP) or cyclophosphamide-epirubicin/doxorubicin-vincristine (CEV/CAV) regimens. The level of evidence is surprisingly low for a disease, the treatment of which is based on drugs like etoposide, anthra- Table 2 Predictive value of multidrug resistance protein 1 (MDR1), multidrug resistance-associated protein 1 (MRP1), multidrug resistance-associated protein 2 (MRP2) and major vault protein (MVP) in small cell lung cancer.…”

DNA Repair Gene Polymorphisms in Relation to Non-Small Cell Lung Cancer Survival

“…Tobacco smoking is the most significant cause of lung cancer, and DNA damage induced by tobacco carcinogens is considered an important pathogenic pathway involved in lung carcinogenesis. Recent research indicates that single nucleotide polymorphisms (SNPs) in the DNA repair genes may influence DNA repair capacity (DRC), and therefore affect the risk of lung cancer and survival of patients [3,4]. Although previous studies focused largely on Asians and less on Caucasians, evidence supporting the genetic involvement of DNA repair genes in lung cancer risk and survival remains inconclusive; more studies with large sample size are still needed.…”

Genetic Variations and Patient-Reported Quality of Life Among Patients With Lung Cancer

“…[33][34][35] All patients who consented to blood DNA samples were genotyped using two custom-designed GoldenGate panels (Illumina, San Diego, CA): one with the 470-SNP panel and the other with the 1,025-SNP panel. One hundred seventy-five SNPs were included in both panels; these formed the basis for the current analyses (Appendix Table A1, online only).…”